
The Third Way to Boost NAD+
How can we conserve NAD+ by preventing overactivation of the enzymes PARP-1 and CD38, which guzzle NAD+?
How can we conserve NAD+ by preventing overactivation of the enzymes PARP-1 and CD38, which guzzle NAD+?
You can naturally get your body to make more NAD+ by boosting the NAD+ synthesizing enzyme NAMPT.
Particular caution should be used for NAD+-boosting supplements by those with cancer, a personal or strong family history of cancer and perhaps also by those with inflammatory disorders and certain active infections.
What are the pros, cons, and efficacy of dihydronicotinamide riboside (reduced NR), perhaps the most potent NAD+ precursor, as well as reduced NMN, taking NAD+ directly, or making it from scratch from tryptophan?
NR may just be a waste of money, safe but ineffective. NMN seems similarly useless in humans, but it may not even be safe.
The suppression of NAD+ synthesis by NR in humans may explain the disparate rodent results.
The metabolism of NAM may deplete our methylation capacity, interfering with the normal metabolism of hormones and neurotransmitters, and produce a neurotoxic compound in the process.
Given niacin’s decades of use as a cholesterol drug, we have a good idea of its safety profile.
The effects of NAD+ boosters on aged rodents have been described in the medical literature as “profound,” “dramatic,” and “remarkable,” but do they help people?
What is NAD+ and what role does it play in the aging process?
The pros and cons of all the NAD+ supplements and what are the ways to boost NAD+ naturally with diet and lifestyle?