Resveratrol and exercise

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Resveratrol Supplements Are Finally Put to the Test

The Magic Bullet for Anti-Aging?

“If one searches the Internet for anti-aging interventions, a vast array of techniques are offered, from starvation regimes to dietary supplements and growth hormones. All are for sale, but none so far have been proven as the magic bullet, despite exorbitant claims on many of the websites.” Resveratrol is one supplement you’ll likely come across, a component of red wine that gained notoriety as a possible explanation for the so-called French Paradox, which turned out to be not so paradoxical after all (see What Explains the French Paradox?).

As I discuss in my video Resveratrol Impairs Exercise Benefits, it turns out that “[c]ountries with high wine consumption are those in which saturated fat consumption used to be low but increased in recent years.” So, the low mortality from ischemic heart disease may just reflect the earlier, lower levels of saturated fat consumption, and the wine may just be a confounding factor. It did, however, help spark interest in resveratrol, the purported active ingredient of red wine about which scientific papers are now published every day.

More than a hundred of those papers on resveratrol have been called into question, though, as one of the leading researchers in the field was found guilty of taking millions in taxpayer money only to fabricate and falsify his data.

Hundreds of studies still remain, though. Does this mean pills can now replace a healthy diet? Even a group of resveratrol scientists don’t think resveratrol is worth supplementing: “In contrast to the lacking data on resveratrol in humans, the animal data are promising and indicate the need for further human clinical trials.” In rodents, resveratrol supplementation decreased cardiovascular risk factors, improved cardiovascular function and physical capacity, and decreased inflammation, leading to improved vascular function. But, when it was put to the test in people, almost the exact opposite was found.

Testing Resveratrol: Mice vs. People

Specifically, combining resveratrol with athletic training abolished the reduction in blood pressure, cholesterol, and triglycerides normally associated with training; had a more arterial-constricting effect than a dilating effect; “and led to a significantly lower increase in the training-induced increase in maximal oxygen uptake.”

Rodents on resveratrol get enhanced exercise performance, but, in people, the resveratrol induced a 45 percent lower increase in maximum aerobic capacity compared with those taking a sugar pill. The human subjects were working out like crazy, and the resveratrol undercut their efforts.

This raises a larger issue. Mouse models are a cornerstone of modern biomedical research, and yet systematic studies as to their usefulness are rarely done. Consider this: nearly 150 human clinical trials testing anti-inflammatory drugs have failed—without exception—after those same drugs had shown promise in trials on mice. In analyzing the carry-over from the mouse trials to the human trials, researchers determined that “[t]he result was surprising, almost shocking: the correlation was not only poor, it was virtually absent for the main study areas: burns, trauma, endotoxemia.” It turns out, for example, that mice may be up to a million times less sensitive to inflammatory endotoxins than humans.

Too Much of a Good Thing?

The takeaway is that the negative effects they found add to the growing body of evidence questioning the positive effects of resveratrol supplementation in humans. Maybe the problem, though, was resveratrol supplementation—that is, giving people capsules containing 50 times the resveratrol they would normally get from eating grapes, berries, peanuts, or chocolate. Was it just too much of a good thing? To see if the amount one gets from drinking red wine would be beneficial, we can look to the Chianti region of Tuscany to determine whether resveratrol levels achieved with diet help protect against inflammation, cancer, cardiovascular disease, and death. The answer? None of the above. Despite the fact that U.S. annual sales of resveratrol supplements have reached $30 million, there are limited and conflicting human clinical data demonstrating any human benefits, and there are no data concerning its long-term safety.

The exercise study was supported in part by a manufacturer of resveratrol supplements. To their credit, however, the researchers responded to an angry letter by a supplement company consultant that “it is our opinion that we, as scientists, have a responsibility to report what we find, and not to twist our findings to fit the commercial interests.”

The benefits of red wine over white do not appear to be due to the resveratrol, but to the estrogen synthase blockers. See Breast Cancer Risk: Red Wine vs. White Wine.

What about the role of red wine in the Mediterranean diet? I have a whole series of videos, including:

I just published a whole new series on alcohol. Check it out:

Sadly, the epic failure of resveratrol supplements is par for the course when it comes to trying to get your nutrition in pill form. See, for example:

In health,
Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live, year-in-review presentations:


Michael Greger M.D., FACLM

Michael Greger, M.D. FACLM, is a physician, New York Times bestselling author, and internationally recognized professional speaker on a number of important public health issues. Dr. Greger has lectured at the Conference on World Affairs, the National Institutes of Health, and the International Bird Flu Summit, testified before Congress, appeared on The Dr. Oz Show and The Colbert Report, and was invited as an expert witness in defense of Oprah Winfrey at the infamous "meat defamation" trial.

61 responses to “Resveratrol Supplements Are Finally Put to the Test

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  1. I think the whole supplement industry is propped up by Mouse Models.

    That might be why they don’t do systematic reviews very often.

      1. Hi Navy Corpsman, thanks for your question. I found this study regarding your question about studies and what animal model is being used. They concluded “that even the presence of conserved processes is insufficient for inter-species extrapolation when the trait or response being studied is located at higher levels of organization, is in a different module, or is influenced by other modules. However, when the examination of the conserved process occurs at the same level of organization or in the same module, and hence is subject to study solely by reductionism, then extrapolation is possible”.
        Animal models and conserved processes

  2. Watching the “Healing Cancer from the Inside” video, last night, they talked about people getting healed from Cancer without taking supplements.

    It is time for WFPB to be put to the test.

    I don’t even care if it is double blind if they get the results they got with Melanoma.

    Our need for double blind studies in science, being stronger than our need for results is something I would like a systematic review on, because that is the point where studies can start to hinder things.

    I am not talking for drugs.

    Those would need double blind.
    So would supplements.

    But if they can get the results of 100% of Stage 1 and 2 Melanoma cured by WFPB, as long as the sample size is more than 1 person, I am for a results testing of a different type.

    And I get that we are afraid of Placebo effect, but when the success rates are high enough, who cares if it is a multiplied exponentially Superhero version of Placebo effect, which comes with hope and confidence and happiness.

    1. One of their comments in the movie is that they think most of the people who are “cured” using the medical model of treating Cancer are “cured” by the Placebo effect.

      That tells me that Cancer could be a way of doing a systematic review of how powerful Placebo effect really is.

    2. I would be very careful about believing everything that is claimed in YouTube videos Or sensational popular health books for that matter.

      Even where they reference studies, they are often cherry picked to support the claims made in the video or the book. For example, the claim that only 2% of cancer cases are successfully treated by chemo

      Sure you can get testimonials from people who recovered from cancer using natural therapies. Say, 1,000 people try this approach but 990 of them die. However, the other 10 will ascribe their survival to the supposed effectiveness of whatever natural approach they adopted and will go on YouTube to say so.

      And if you are a doctor with a sensational cure protocol, you can use it on 1,000 people. And if 990 of them die, you can still do case studies on the remaining 10 to “prove” how effective your protocol was.

      The fact is that studies consistently show that people who refuse conventional cancer treatment for alternative therapies die earlier on average eg

      1. I understand Tom, but these were doctors.

        John McDougall and T Colon Campbell.

        Eating You Alive, Dr Fuhrman walked people through.

        1. They said that you can’t just throw super foods at Cancer and have it go away.

          People need to also get rid of the animal products and they had the enzyme theory where the enzymes which expose Cancer to the immune system are the same enzymes which digest meat and if they are used to digest the meat, they aren’t available for exposing the Cancer.

          I respect the people in this documentary.

          I also watched What The Health and it is horrifying that we can’t trust the Medical Industry or Food Industry or government to tell us the truth at all.

          1. What makes you think that you can trust the producers of YouTube documentaries to tell us the truth? Anybody can show clips of Campbell etc – it doesn’t mean that those individuals endorse all or even any of the claims in the video.

            YouTube videos are full of falsehoods and inaccurate statements of fact – whether made by people selling stuff online to boost their sales, or by opinionated crackpots. A common tactic they use is to claim that the evidence showing their claims to be false is a lie manufactured by an unholy combination of industry and government.

            1. Please do a full research on big Pharma historically then answer alternative therapies ,
              And please tell all what chemo really is a poison ,
              Please tell people how big Pharma came across chemo the drug the killer poison
              Dr James Allison Mexico do some research on him
              So please don’t discredit people who wish alternative therapy until you have sat next to someone who was given 6 months to live by nhs and we kept him going nearly two years until a bad infection got him after an op
              Then tell all about the kick backs all health services get for handing out the drug alone ,
              And please wake up

              1. Hey there not sure if everyone will get this message but i have comments to add about my personal experience with resveratrol in natuarl form.

                Not the supplements. I consume alot of knotweed. I will sound like a sales pitch or infomercial but my experiences are real and true. I have told everyone locally about it and tell them how to make it.

                My experiences: I have lost weight without dieting.. 40 pounds.
                At times i feel i cant eat enough, constant hunger which is a DOWN side and i will cut back on the root tea to adjust.

                My wieght stabalized at 191. I eat eanything until im full. My pants size is down to 32.

                i lost 40 pounds but wieght distribution is equal to my charts when i was in my early 20s. (Used to be a trainer and kept records.)

                I noticed my over all energy level has increased (at 46 years old).
                I run through forest track obsticles.
                My running speed increased.

                Stamina and heart rate recovery seem higher than a few years ago.

                HR recovery: measured full arobic @ 137 bpm

                Currently: My lowest resting heart rate is recorded at 42 bpm at 46 years old and was only 65 bpm when i was in my 20s.

                It Has dipped to 38 bpm and 41 bpm but only once. Records are logged with ER heart rate monitor and home devices.

                At 46 my heart is in the best condition its ever been in my life.

                Using parts of the root for skin.
                Smash add water to make gel.

                Used in hair: Grey hairs reduced. (I wasnt grey but had too many to pull out. Today i have a few grey hair only) and tpok notice 2 daya after applying.

                Hair conditioning texture is similar to my 7 and 8 year old daughters hair.
                Soft shiny and strong

                Gel is an Extreme absorbent moisturizer. Skin absorbs in seconds.

                Used for hands feet and face or all over body with raw gel

                Fussion methods with organic extra virgin olive oil added works extrodinarly well.

                Has been used all over my body.

                Skin tightens.
                Skin absorbs gel like a sponge and seems to tighten areas around arm creases for instance. Bags under eyes disappeared.

                Lotion will be completely silky and…

                Absorbed by the skin within minutes until dry / no residue.
                Has Charateristics of soap

                Wrinkles: appear to be fading away ( i also use coco oil, raw gel and oiled gel. ) Fyi no drugs or alcohol

                Feet: Will completely remove odor Seems to work against fungus.
                Lotion seems to dry similar to the anti-bacterial hand cleaning lotion.

                Body: Can be used as personal lubercant.
                Body seems to absorb into muscles and builds muscle tone.
                Less skin sag in those areas overall

                This plant seems to homestly be making me get younger. At this rate i look forward to youth at 50 years old.

                The nature of the plant dies i to old wood. Will that happem to me?

                1. Will prolong use work?
                Is cancer growth possible or other unknow disease?

                2. Lab rat testing mentions tiny blood capillaries rupture. I noticed some things like that, actually. but not sure if its related. Its Wise to keep a close eye on this.

                3. Will the appearence of youth nackfire after long use? 2 cases of liver failure reported from a woman and a man taking reseratrol suppiment and chinese knotweed. Not confirmed was the reason

                As for my personal experience… I swear by it.

                  1. we have hundreds of thousands of it on our property.

                    I make tea from the roots and the stems.
                    making tea from the stems and leaves alone gives a great lemony green tea.
                    The roots give a spicy (yes adding pumpkin spice seems a match in heaven) but i use ginger root and lemon to make the root tea, i mix the green stems and roots for optimal refreshment and energy and yes the energy levels can be amazing.

                    The resveratrol claims to be anti-aging but i found that to be very very true in physical out put, but i feel my face may have also aged a little faster- i have been under a lot of stress tho too.

                    I also found out you can make a wine type of alcohol from it too. My treas and juices were left in the fridge for too long ( i make 5 to 10 gallons at a time) The last batch i made with a lot of brown sugar. I took a chug, and got a fast unique buz. but i have to learn the process of wine.

                    If you go to kick search Mexican Bamboo. japanese knotweed, i have pics there and some ideas i can up with.

                    The problem with this plant is it is extremely invasive and once you plant it, you will never get rid of it. It also takes tremendous efforts maintaining it and when (not if) it gets out of control, you will need to excavate 3 meters deep. Its also destructive to sidewalks but is a very beautiful plant.

                    We happen to be lucky, ours grow along out natural springs. I love it.
                    there is such an incredible difference in my health.

                    There are other products make as well. I use the plant daily. I use it for skin care, moisturizer, tea, juicer, taco filler, salads and decoration. I have also just completed a 15 foot tall privacy natural fence around out fire pit.

                    There is so much to this plant. I dont want to sound creepy, but the nodes can be used for a silky hand softener and (well…) as embarrassing as it seems, the gel the nodes are also used to make personal lubricant. It feels identical to female vaginal secretion and i use the nodes for sexual encounters. If i were to try to market this – id sell it off the roof.

                    The resveratrol in the plant stimulates erections, and at 46 my last sexual encounter using this gel i get erections 5-10 times a day can even get distracting. (this is not an ad if it sounds like one)

                    On a scientific aspect, id like to elaborate on this. The topics of sex and masturbation is not comfortable for me to speak about, but in all reality, there is currently no products that have the exact consistency as vaginal secretion that is 100% all natural (like aloe) and truthfully, thats in the ‘top 3’ reasons of being with a woman (of course love too).

                    I am a hobbie scientist. I wish i knew how to market products.

                    the node gel is 100% organic – simply harvesting, preparing and chopping the nodes mixed with water would knock the block off of current hand creams and KY gels that are currently on the market. I have an endless supply of this plant.

                    Thanks for reading this long email.

                    In short – if you dont have it, dont get it – you will never get rid of it.
                    it will overtake your property, leave you with dead shoots all winter (which i may add something about the dead stalks, they are almost as flamable as gas. I also use them for fire heaters and outdoor fire pits.
                    Its so flamable.

                    There are numerous things i use this plant for on a daily basis, all year and seasonal treats. its amazing.

                    If you area scientist, or if you are good at packaging and marketing, I could be sitting on multi millions. – if i only had the brain for that and all the capital needed is for harvesting. other than that it grows 6-8 inches a day untill its about 8-10 feet tall.

                    Thanks for reaching out. hope this helps.

  3. “It turns out, for example, that mice may be up to a million times less sensitive to inflammatory endotoxins than humans.”

    Humans are missing something important. Vitamin C.
    Mice produce C in relatively large amounts constantly.
    Humans can’t do this anymore. (Lost that ability to a genetic mutation long ago.)

    Need to test with non-C producing mice for a better comparison with humans.

    Vitamin C is minimized by the medical community, perhaps because it could reduce the need for many expensive drugs.

    People that mega-dose C (like most other animals to naturally) gain a lot of interesting advantages. Surprisingly, they don’t get drunk when they drink. Imagine that! C is anti-toxin. Guess what alcohol is …

    1. Does the alcohol still show up on breathalyzrs?

      If I had an alcoholic relative, I might start serving them food with mega foses of Vitamin C.not sure it would work, but getting rid of the sense of being drunk might make it less of a draw.

      Universities could use it to stop people from doing drunken behaviors. Harder to justify that type of thing when you are sober.

    2. Richard Where did you find this little gem “People that mega-dose C (like most other animals to naturally) gain a lot of interesting advantages. Surprisingly, they don’t get drunk when they drink.” ?

      It’s not true.

    3. “People that mega-dose C (like most other animals to naturally) gain a lot of interesting advantages. Surprisingly, they don’t get drunk when they drink. Imagine that! C is anti-toxin. Guess what alcohol is …”

      those mega doses do nothing for you. your body takes what little vitamin C it needs and you urinate out the rest.

  4. I was having problems with capt cha all day and can only comment by getting around it.

    If I am banned for something let me know and I will stop going around the defenses.

  5. Your comments page has sunk to a new low.
    I’ve tried to make an entry several times, without success.
    Was it something I said?

      1. Podcast is still banning everybody.

        It was on Autism. My question for the powers that be is have they ever tested the link with Aluminum or Copper or Blood Sugar/Insulin with Autism.

        I probably have to look at the Air Pollution video.

        I am asking, because I have been drinking the Fiji Water and have been supplementing Zinc and I haven’t had hallucinations the past 2 nights.

        I haven’t succeeded as well with the fasting every night yet, but I am aiming for it.

        I just have such poor time management still as part of the Alzheimer’s, that I end up not eating dinner until 9 or 10 at night and I am still not falling asleep until 4 am, so it isn’t sleep and it isn’t sleep apnea.

        Hooray! Hooray! Hooray! I didn’t have hallucinations! Hooray! Hooray! Hooray!

        1. I am laughing, because I intentionally came off the cheese which has the coconut oil in it and am not taking coconut oil or olive oil.

          Happy that I had improvement without the added oils.

          John Robbins did a good talk on Coconut oil yesterday. That it didn’t hurt people who were eating a Plant Based Diet, but it didn’t help the ones who had a lesser diet either.

          I am not gonna take it, unless everything else fails.

          I even threw my container of coconut oil out. If Dr. Barnard can heal Alzheimer’s too and eating less oil will help better with weight loss, I can see what happens over the next year.

          If the hallucinations aren’t completely gone and if my cognitive abilities and time management and sleep cycle hasn’t improved, I can try coconut oil then, right before sleep study.

    1. I am with you about the food.

      Supplements are so expensive and so are Organic foods, but the foods beat the supplements in so many of the tests without the risks.

      I don’t have enough money to do both and food is working better.

  6. Hello!

    I’m currently a stranger named felix, and I have a problem.

    I spend on average 2 hours each day cooking fresh food for my boss and colleagues. My boss places VERY high importance in healthy food and nutrition, but he’s open for suggestions on how we can save time.

    I suggested to him that we could cook all the meals for one or multiple weeks at the same time and then put them in the freezer. This would save me a lot of time to work on other important tasks, but he wants to make sure that this will not make the food less healthy (loss of nutrition).

    I have read your book “how not to die” and also checked out your article about frozen fruit:

    and your video:

    A couple questions I have found impossible to get answered are the following:

    – Does prepared food (heated fresh fruits, vegetables and beans) lose nutrients when I put them in the freezer to eat later?

    – Does it matter if I have them in the freezer for just a few days, weeks or even months?

    – Also, will it lose nutrients when I heat the frozen food up again?

    Thank you and I’m looking forward for your answer :)

    1. If you’re going to preserve your meal for several days, you should also pay attention to the methods you’re using for cooking, as most of the nutrients can be lost during the cooking process. If you have concerns about which method to use, check this info that might be helpful as it gives advice about how to preserve nutrients in a better way.

      Regarding freezing, that’s an excellent method for nutrient preservation! However, you can experience changes on flavor, texture, color and other organoleptic qualities fo the food, which I think are also important when eating.

      This web from The National Center for Home Food Preservation will be very helpful for you, as it gives you advice about how to frezze different kind of foods, including common fruits, vegetables and beans.

      According to what I’ve been reading, it’s recommended to keep frozen food about 3 – 6 months.

      And finally, the nutrient loss after freezing will depend on the cooking method you choose. So, you probably want to check the first web page I shared. I guess, hydrosoluble vitamins will be the ones at more risk of degradation.

  7. I was just at Food Revolution Summit Facebook and ended up confused about sugar.

    They had a video up about sugar csusing obesity, heart disease and diabetes.

    Dr Barnard says that it isn’t sugar which causes obesity or diabetes and uses a chart where sugar consumption flat lined but obesity and the diseases went through the roof similar to meat and cheese consumption. He pointed to Dr Kempner giving sugar with rices do fruit to Diabetics and they lost 100 pounds and had greatly improved health.

    Another of the speakers is against flour and sugar and I don’t know the rationale, because John McDougall allows even wheat bread, I think and Dr Barnard allows everything except white and wheat.

    Okay, is there a study for sugar causing heart disease or obesity or diabetes or Cancer or is it the lard in the baked goods, like Dr Barnard says?

    I need it to be a study, because my Keto friends use the bad sugar logic.

    I bought date sugar based on it having nutrition, is it better to have none at all? I am not uding it yet, but inquiring minds want to know.

    1. Resveratrol Supplements. I am currently in an NIA double blind study on this supplement. (Was told that no one has ever done a human double blind study) Placebo/75 mg/.100 mg. Do not know which one I got but it is a year long involvment for each particpant and I vaguely remember that 300 people of all ages are particpating. My year is up in early July. Do not know when the paper for this will get published. Study is being done at NIA at Medstar Harbor hospital in Baltimore.

      There was a lot of testing at the beginning of the study including strength testing, FEV, treadmill, and blood ffow velocity. I take 2 pills a day. I have periodically gone in for blood tests.

      If you have any?s, Email me . BTW, I do not drink red wine since I get headaches almod immeadiatley from the wine.

      BTW, great we site and on going updating. Follw your diet reccomendations a lot.

  8. He isn’t While Food Plant Based in his belief system.

    I watched his next series promo vidros and he believes that everybody should trust their own body, which is what my Fodmap and Keto friends believe.

    I am thinking it is more like stretch receptors and pleasure traps and cheese traps.

    I feel like everybody listening to their own body before choosing WFPB is how we end up with America in the first place.

    I get his point that everybody’s gut processes food differently, but the research he was talking about was whether blood sugar spikes or not, but I thought Dr Barnard saying it spikes for a little while, but goes away in a few weeks is what I thought made sense, along with trying go get the good gut bacteria.

    I am doing John’s next series, but I already want to jump and find WFPB and save that type of voice until I am more at my goals.
    I love that he is compassionate and loves plant foods, but I genuinely get confused.

  9. It seems like the stretch receptors are a good example.

    A few people can trust their stretch receptors even if they eat fats.

    Most people get the wrong answer trusting their stretch receptors if they are eating fats and push past the stretch receptors if they are eating addictive foods.

    Sugar would be something people push past their stretch receptors about,
    Maybe we can just trust our bodies to only eat 5% of meat, but we can’t trust it about dairy and one egg is too much and our bodies don’t warn us.

    I think our bodies not warning us about eggs is all I need.

  10. What grieves me about it is that if I hadn’t spent these past months intentionally trying to be OCD at renewing my mind about nutrition and watching every Dr Greger How Not to Die video and every Cancer and Heart Disease video and videos from Dr Barnard and Pritikin And John McDougall and T Colin Campbell and documentaries like What The Health and Eating You Alive – and Dr Lisle videos…,,

    I needed ALL of them to analyze What just happened.

    I don’t know if you doctors understand that.

  11. I am more than just a little bit upset, because I know that John Robbins is brilliantly over informed at a level where he wouldn’t even know how much his brain would be involved with telling him what to eat.

    His video about his core belief system is that your body might need something which goes against what you know to be healthy and which goes against the research and listen to that inner voice instead of following the science to make your decisions.

    Some people’s bodies tell them to eat lead paint or tells them to have a chocolate addiction and chocolate addiction from being too low in Magnesium is where I started and yes my body had a wisdom for giving me those cravings, but it didn’t warn me I was craving something dangerous.

  12. I just realized that I got rid of sugar and flour almost all last year and didn’t lose a pound.

    I got rid of milk and cheese and started losing.

    It is only the claims about heart disease that I need a study on.

  13. I watched more videos from more people tonight and feel like I am understanding it better.

    I feel like I broke through mentally a little bit.

    It might be placebo effect or I watched enough videos and read enough blogs so that I am capable of going further in the process.

    In some ways, I almost feel like I am just going to keep swapping one thing at a time.

    Today, we had a Memorial Day party and I was asked to bring a casserole and I made two. One was vegan and that was the one, which was eaten, because nobody could look at it and tell the difference. The other one is getting thrown out.

  14. Resveratrol Supplements. I am currently in an NIA double blind study on this supplement. (Was told that no one has ever done a human double blind study) Placebo/75 mg/.100 mg. Do not know which one I got but it is a year long involvment for each particpant and I vaguely remember that 300 people of all ages are particpating. My year is up in early July. Do not know when the paper for this will get published. Study is being done at NIA at Medstar Harbor hospital in Baltimore.

    There was a lot of testing at the beginning of the study including strength testing, FEV, treadmill, and blood ffow velocity. I take 2 pills a day. I have periodically gone in for blood tests.

    If you have any?s, Email me BTW, I do not drink red wine since I get headaches almod immeadiatley from the wine.

    BTW, great web site and on going updating. Follow your diet reccomendations a lot.

  15. Dr. Greger, The very sweet-voiced woman from Plant Based Science London called you wrong about B12, using Dr. Klapers logic.

    He says that some people can’t methylate properly.

    I have tried to post my version of your B12 answers, but I will say that your B-12 section I think is missing some tags, because the dosage ones were hard to find. Was it you who said that the Methyl Prefix needs to be removed and then another Methyl gets put on?

    Or did I get that from someone else?

    Anyway, I might double and triple ponder everything you say, but I didn’t like her posting you as wrong without you getting a rebuttal.

  16. “Rodents on resveratrol get enhanced exercise performance, but, in people, the resveratrol induced a 45 percent lower increase in maximum aerobic capacity compared with those taking a sugar pill. The human subjects were working out like crazy, and the resveratrol undercut their efforts.”

    I have a problem with the confusing wording in the above paragraph… specifically, the part that says “in people, the resveratrol induced a 45 percent lower increase in maximum aerobic capacity compared with those taking a sugar pill.”

    So, if the increase was only 55% in maximum aerobic capacity, isn’t that a statistically important improvement?… and an improvement without having to consume sugar? (Maybe that’s why athletes eat candy during a performance?)

    I have to say this appears to be twisting the results by obfuscating what the outcome really is. I’ll continue on resveratrol plus pterostilbene.

      1. In my experience with trans-resveratrol is it seems to give energy 30 minutes to 24 hours after consumption. Its definitely longer term energy vs drinking a red bull style boost. I am not sure about max aerobic but with endurance and strength – i notice a major difference. I drink the resveratrol as a tea with sugar added for sweetener.

  17. i have been consuming resveratrol in other ways, i in fact did notice results matching the mice. Id like to speak with someone about this. I have been using a natural process to make an energy drink.

    I noticed i was loosing weight and my running ability was increasing. I noticed I was able to eat whatever i want.

    Is it too much resveratrol? or too many chemicals that are used to extract the resveratrol? I make it straight from the source using time and temperature as the only chemical medium.

    1. i want to add, i had no idea knotweed had resveratrol, i never heard of it. I actually was trying to find a way to remove the knotweed from around the natural spring in our property and found out it was edible. From there i went on a cooking mission. A few months of intake, i noticed i was eating alot, i was not going to the gym, all of the sudden i saw my self looking like i have been working out. It wasnt until then that i researched to see if knotweed had any allergies that could possibly make me sick and loose weight. I continued and tried consumption and then stopped and noticed changes in the physical effects. Since then i have been focusing on it. My knotweed has never had a single chemical on it, nor the land it grows, nor the natural spring for 200 years the we know of at least.

  18. Genetics Professor Sinclair at Harvard Medical School himself supplements with reservatol, NMN, and metformin. He also claims that the majority of his colleagues in age-related research use supplements. The question is that surely Dr Sinclair who is more qualified than Dr Greger knows the scientific literature enough. There are side effects to supplementing, but why does he view it as worthwhile then. Is he just delusional or in with BigPharma?

  19. ATTN: Dr. Greger

    Re: Anti-Aging Research — Chemical Formulation “RTB101”


    After conducting some human experiments, some people are now claiming that the chemical “RTB101” greatly boosts our immune system AND dramatically increases our life spans.

    An article about “RTB101” appears in the June/July AARP magazine (p.56ff).

    Would you kindly create an article to scientifically comment on these claims?

    Thank you! …Dr. Frank “Mike” Davis

    1. hello i wanted to add, that i have been consuming the knotweed plant which is very high in resveratrol. I can not say much about the products, but hands down, i noticed a huge change in youth – i had stopped taking it because i have been busy and the process to turn it into a drink is very time consuming – after a 2 months without it – i notice the difference 100%. There is no doubt in my mind this plant is amazing! and when you stop it declines, and as soon as i start taking it again i see, and others around me also see the difference. thanks for the update.

  20. I have multiple myeloma. My numbers have been stable. I stopped taking Resveratrol two months ago. My numbers spiked. This has happened twice. It works. Dr. Greger is wrong.

    1. Hello everyone, I have been consuming Knotweed plants and roots which i also use in conjunction with topical use creams and oils i make, as a lubricant i came up with using 100% of the plant. The roots cut with the right tools can be eaten like a nut meg, and the outer bark is edible after boiled. I make teas from the roots this way.

      Knotweed is the plant that most resveratrol products use for production.

      I have noticed a tremendous difference in my health and preserved aging.
      Recently I was asked if i use coloring in my hair. I have gone from people thinking i was 55 ish to 31 ish in he last 2 years in fact yesterday a guy (24 years old) asked if i was 31 (im 47)

      * weight and strength training* As far as weight and strength. I make potent tea before working out, highly concentrated with cut root. (roots are sliced into 1/2 inch patties then boiled and cooled for 1 hour with sugar added.. I am leg pressing 750 pounds at the moment 6 sets of 10.

      Sometimes i feel that the tea gives me super powers. I have incredible energy, but its not from taking it right away, it seems as long as i continue ingesting it the energy comes when i need it – yet also keeps me desiring to work out and stay active or i get restless.

      Mixing sugar with the tea 30 minutes before the workout is a clear noticable difference then just taking the tea alone, and also testing results by just taking sugar.

      The combo of the two are noticble by others at the gym. It enables me to continue working out with little rest between sets and “keep going” for hours It also increases my sex duration to an average of 45 minutes.

      I skate board, and climb trees for recreation (80 feet tall) With weight, sex is also increased, . I notice wrinkles are still coming, but not so bad. The weight will distribute more evenly when i gain weight. Its one thing about staying hopefull, but other friends from HS are also noticing it.

      I also notice i seem to stay “In shape” better as im aging. My pecks and arms are holding their shape very well even with reduced athletic activity.

      Eventually I will make the tea marketable if anyone is interested in investing into marketing let me know. I have secret receipts from personal experimentation for taste and energy..

      You can taste the natural extracted medicine and sometimes I felt its possible to over due it – and drink too much. In those cases I seem to have trouble sleeping.

      *Maintaining being attractive to the opposite sex:* I get approached by girls 15 years younger and i will tell you that regardless of any other research articles or not, I will never stop using this plant. Its a part of my every day use.

      *Topical lotions:* have made oils for the skin and skin lube, I do use other natural moisturizers like coconuts and like products.

      I have used it for *sex lube* with a female partner and is the best absorbent and silky lube i ever used and refuse to use any other products for this activity – *”i make my own resveratrol topical lube”*.

      *Hair:* i put a different slow aged fluid in my hair and i lost my grey hair with a full head of hair. (still a few but not many)

      *Food:* I make taco filling, salsa and smoothies form the young plant stocks.

      *Recreation and decor:* I also use the plant to decor private camp fire area around the house, The dried stocks from the year prior (or if you cut the stocks and dry them) they light as fast as gas and great for starter wood in the camp fire.

      I included some pics if they are able to be scene.
      I am standing next to my cousin who is 23 and his buddy who is only 20.

      I am 47, I will quote a researcher who said it doenst stop you from aging, it slows aging down and allows you to age better.
      It will be in my life forever.

      I hope my personal experiences ingesting this resverator by consuming knotweed helps your study.

  21. Hello,

    I have a question;
    Is it safe to take NMN supplements in order to gain longevity?
    Which supplements are safe to take?

    Thanks a lot,

  22. I made several lifestyle changes starting in August of 2019, one of them being resveratrol supplementation. I quit smoking, started regular resistance and aerobic training, revamped my nutritional intake with the macros being roughly 25% carbs & protein and 50% fats. I lost almost 40 pounds and at 61 just had my yearly physical and my blood work looks great. Granted I knew my overall cholesterol and even LDL levels would be up because of all the healthy fats but HDL is 96 and tryglyceride is 55 while LDL is a tad high at 149. However all the ratios are amazingly beyond the ideal level. Glucose is 91. BP is 124/82 and that’s the right arm and probably due to the normal anxiety associated with getting BP taken at the provider combined with my company’s 80% premium hike and a ‘voluntary’ wellness program that will discount the radically increased premium if certain metrics, including BP, are met. My at-home BP monitoring generally comes in between 115-120/75-80 and one of the reasons for all this is it was topping out around 145/95 back in August.

    Workouts. I’ve worked out on and off my entire life and I notice no negative impact this time while supplementing with resveratrol. In fact this past weekend I took a short 1.92 mile loop hike up a small mountain, 1,600 feet with a 672 foot gain in elevation. In 12″ of fresh snow. With clod-hopper Baffin arctic-rated boots (-45 F) with crampons that weight about 3 pounds each. The loop is one of several in the local town’s fitness challenge series and is rated a 2 hour circuit. I did it in a little under 3 hours and that was stopping to take pictures. Lots of them!

  23. Doctor Greger is quoting a lot of old research in this piece. The discredited scientists report was published and concerns a 9 whole years ago. (2011).

    I’m not going to good mouth this as a supplement but I do want to say that supplementation, and certainly a phytochemical would not be congruent with doctor Greger’s philosophy on nutrition and wholism even if it ever was shown beneficial to begin with. For example, there is a tablet with fytochemicals from tomato seeds that works like an aspirin without ill effect, I think it is called fruitflow. If the tomato seeds extract (DSM produces it) works you don’t hear Dr. G mention anything about it ever, no he would rather talk about consuming 6 whole tomatoes every day in some disgusting V8 drink, try doing that every single day. The tablet is standardized, easy to use, reliable. We deserve such information but we’re not getting it because it’s against Michael Gregor’s philosopical rhetoric…

    Same with standardized sulphoraphane supplements, certainly from companies that are used in clinical trials or advised by experts in the field. There’s people bothering with unreliable quantities in some random broccoli bought at the store or even worse, putting freaking mustard seed over frozen broccoli, the taste is vile and disgusting, it requires half a freaking teaspoon per 100 grams. Who’s going to bother with this 3 times a week?? But he never mentions the supplement, because it’s against his personal ethos.

    I’m not an expert so unfortunately, it’s difficult to rebut his article, but after following his work for years now, I certainly have seen this again and again. Don’t get me wrong he really is the best there is, but this is just one part of it that I’m not very fond about.

    I’ll just leave these comments by someone other then me, no idea wether it is legit, this should be Dr. G’s work if he was without bias one could actually believe him. I’ll also post a more recent review.
    Recently, a study by Lasse Cliemann and colleagues suggested that high doses of resveratrol (250 mg/day) may blunt the beneficial effects of exercise. The publication garnered a lot of media attention, with different outlets creating their own spin on the topic. For another perspective, we have asked various professionals for their views on the study.

    There are many debates such as this one that should continue to take place in the nutrient/nutraceutical research. Perhaps it is a cultural bias that has us assuming “more is better.” Perhaps it is a multibillion-dollar supplement industry with a vested interest in perpetuating this bias. We now know that minute quantities of reactive oxygen species (ROS) are essential to life, and that high levels are detrimental. The concept that nutrients also have doses that are beneficial, beyond which they are detrimental, is in keeping with the idea that optimal physiological function is a balance within the cells and the organism as a whole. Practitioners of many ancient medicines around the world understand this concept; the symbolic yin/yang is familiar to most Westerners as well. I look forward to clarification of natural agents and their optimal doses for physiological benefit. I fully expect that we will learn that each has an elusive “sweet spot dosage,” and that biochemical individuality will keep that “sweet spot dosage” elusive for quite some time.
    —Tina Kaczor, ND, FABNO
    The fact that low levels of ROS play an important role in promoting health represents a fundamental change in biological understanding.

    Original Study
    Gliemann L, Schmidt JF, Olesen J, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol. 2013 Aug 19. [Epub ahead of print]. Click here for full text.

    The revieuw.

    Wiciński, M., Leis, K., Szyperski, P., Węclewicz, M. M., Mazur, E., & Pawlak-Osińska, K. (2018). Impact of resveratrol on exercise performance: A review. Science & Sports. doi:10.1016/j.scispo.2018.02.010

  24. Although resveratrol has been shown to elicit beneficial effects on metabolic and neurological parameters, studies investigating the effects of resveratrol on exercise training are contradictory. One study involved 27 men between the ages of 60 and 72 years who participated in an 8-week training program with two days of cycling and one day of Crossfit. Each of the men took a 250 milligram resveratrol supplement daily. The resveratrol supplement blunted the positive effects of exercise training on blood pressure, blood cholesterol, and maximal oxygen uptake observed with exercise alone.[34] However, a similar study involved 30 men and women between the ages of 65 and 80 years who participated in a 12-week resistance and aerobic training plan three days a week and took a 500 milligram supplement of resveratrol per day. At the end of the training program, the participants experienced an increase in mitochondrial density, muscle fibers, and maximal oxygen consumption compared to exercise training alone.[35] Another study in which 22 year old men who engaged in four weeks of high-intensity interval training three days a week and supplemented with 150 milligrams of resveratrol per day, the lowest dose of the studies mentioned so far, did not promote increases in the men’s aerobic or anaerobic capacity, exercise substrate utilization, or muscle fiber-specific adaptations compared to exercise alone.[36]

    The type of exercise, intensity, and the dose of resveratrol may contribute to these contradictory results. More studies are needed to determine how resveratrol supplementation affects exercise performance.

    ^ Gliemann, Lasse, Jakob Friis Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, et al. ADM {Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men} The Journal of Physiology 591, no. 20 (August 2013): 5047–59. ADM []

    ^ Alway, Stephen E, Jean L McCrory, Kalen Kearcher, Austen Vickers, Benjamin Frear, Diana L Gilleland, Daniel E Bonner, et al. ADM {Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women} The Journals of Gerontology: Series A 72, no. 12 (May 2017): 1595–1606. ADM []

    ^ Scribbans, Trisha D., Jasmin K. Ma, Brittany A. Edgett, Kira A. Vorobej, Andrew S. Mitchell, Jason G.E. Zelt, Craig A. Simpson, Joe Quadrilatero, and Brendon J. Gurd. ADM {Resveratrol supplementation does not augment performance adaptations or fibre-type specific responses to high-intensity interval training in humans} Applied Physiology, Nutrition, and Metabolism 39, no. 11 (November 2014): 1305–13. ADM []



    I suspect that you’ll measure benefits in older individuals exercising but RSV does not augment, but may impair training adaptations in younger individuals. Something also seen in other studies on antioxidant supps. For what it’s worth.

  25. Once again, I don’t care about resveratrol, it’s something highly questionable to supplement but I’m just saying, there’s other stuff out there. Stuff were missing out on more often then not.

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