Resveratrol Impairs Exercise Benefits

Resveratrol Impairs Exercise Benefits
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Research on resveratrol, a component of red wine, looked promising in rodent studies, but what happened when it was put to the test in people?

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If one searches the Internet for anti-aging interventions, a vast array of techniques is offered, from starvation to supplements. All are for sale, but none, so far, has been proven, despite the exorbitant claims on many of the websites. Resveratrol is one you’ll likely come across, a component of red wine, which gained notoriety as a possible explanation for the so-called French Paradox, which turns out is not so paradoxical after all.

Turns out that countries with high wine consumption are coincidentally those in which saturated fat consumption used to be low but increased in recent years; so, the low mortality from ischemic heart disease may just reflect the earlier low levels of saturated fat consumption—the wine may just be a confounding factor. But it did help spark interest in resveratrol, the purported active ingredient of red wine, on which scientific papers are now published every day.

More than a hundred of those papers have been called into question, though, as one of the leading researchers in the field was found guilty of taking millions in taxpayer money only to fabricate and falsify his data.

Hundreds of studies remain, though; so, can pills now replace a healthy diet? Even a group of resveratrol scientists don’t think resveratrol is worth supplementing. In contrast to the lacking data on resveratrol in humans, they say the animal data are promising and indicate the need for further human clinical trials. In rodents, resveratrol supplementation decreased cardiovascular risk factors, improved cardiovascular function and physical capacity and decreased inflammation, leading to improved vascular function. So, it was put to the test in people, and almost the exact opposite was found.

Specifically, taking resveratrol with athletic training abolished the reduction in blood pressure, cholesterol, and triglycerides, had a more arterial constricting effect than a dilating effect, and led to a significantly lower increase in the training-induced increase in maximal oxygen uptake.

Rodents on resveratrol get enhanced exercise performance, but in people, compared to those taking the sugar pill, the resveratrol induced a 45% lower increase in maximum aerobic capacity. Here, the guys are working out like crazy, and the resveratrol is undercutting their efforts.

This raises a larger issue, though. Mouse models are the cornerstone of modern biomedical research; yet, systematic studies as to their usefulness are rarely done. This one was done on inflammation after nearly 150 human clinical trials testing drugs that looked promising in mice failed without exception. The result was surprising, almost shocking.  The correlation was not only poor, it was virtually absent for the main study areas: burns, trauma, and endotoxemia. Turns out, for example, mice may be up to a million times less sensitive to inflammatory endotoxins.

But anyway, the negative effects they found add to the growing body of evidence questioning the positive effects of resveratrol supplementation in humans.

Maybe that was the problem, though. It was resveratrol supplementation, giving people capsules containing 50 times the resveratrol they would normally get eating grapes, berries, peanuts, or chocolate. Maybe it was just too much of a good thing. To see if the amount one gets drinking red wine would be beneficial, we can look to the Chianti region of Tuscany, to determine whether resveratrol levels achieved with diet help protect against inflammation, cancer, cardiovascular disease, and death. And the answer is, none of the above. Although annual sales of resveratrol supplements have reached $30 million in the United States alone, there is limited and conflicting human data demonstrating any human benefits, and there are no data concerning its long-term safety.

The exercise study was supported in part by a manufacturer of resveratrol supplements; yet, to their credit, the researchers responded this way to an angry letter by a supplement company consultant: “It is our opinion that we, as scientists, have a responsibility to report what we find, and not to twist our findings to fit the commercial interests.”

To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. This is just an approximation of the audio contributed by Katie Schloer.

Please consider volunteering to help out on the site.

Images thanks to Robert Allen via Flickr.

 

If one searches the Internet for anti-aging interventions, a vast array of techniques is offered, from starvation to supplements. All are for sale, but none, so far, has been proven, despite the exorbitant claims on many of the websites. Resveratrol is one you’ll likely come across, a component of red wine, which gained notoriety as a possible explanation for the so-called French Paradox, which turns out is not so paradoxical after all.

Turns out that countries with high wine consumption are coincidentally those in which saturated fat consumption used to be low but increased in recent years; so, the low mortality from ischemic heart disease may just reflect the earlier low levels of saturated fat consumption—the wine may just be a confounding factor. But it did help spark interest in resveratrol, the purported active ingredient of red wine, on which scientific papers are now published every day.

More than a hundred of those papers have been called into question, though, as one of the leading researchers in the field was found guilty of taking millions in taxpayer money only to fabricate and falsify his data.

Hundreds of studies remain, though; so, can pills now replace a healthy diet? Even a group of resveratrol scientists don’t think resveratrol is worth supplementing. In contrast to the lacking data on resveratrol in humans, they say the animal data are promising and indicate the need for further human clinical trials. In rodents, resveratrol supplementation decreased cardiovascular risk factors, improved cardiovascular function and physical capacity and decreased inflammation, leading to improved vascular function. So, it was put to the test in people, and almost the exact opposite was found.

Specifically, taking resveratrol with athletic training abolished the reduction in blood pressure, cholesterol, and triglycerides, had a more arterial constricting effect than a dilating effect, and led to a significantly lower increase in the training-induced increase in maximal oxygen uptake.

Rodents on resveratrol get enhanced exercise performance, but in people, compared to those taking the sugar pill, the resveratrol induced a 45% lower increase in maximum aerobic capacity. Here, the guys are working out like crazy, and the resveratrol is undercutting their efforts.

This raises a larger issue, though. Mouse models are the cornerstone of modern biomedical research; yet, systematic studies as to their usefulness are rarely done. This one was done on inflammation after nearly 150 human clinical trials testing drugs that looked promising in mice failed without exception. The result was surprising, almost shocking.  The correlation was not only poor, it was virtually absent for the main study areas: burns, trauma, and endotoxemia. Turns out, for example, mice may be up to a million times less sensitive to inflammatory endotoxins.

But anyway, the negative effects they found add to the growing body of evidence questioning the positive effects of resveratrol supplementation in humans.

Maybe that was the problem, though. It was resveratrol supplementation, giving people capsules containing 50 times the resveratrol they would normally get eating grapes, berries, peanuts, or chocolate. Maybe it was just too much of a good thing. To see if the amount one gets drinking red wine would be beneficial, we can look to the Chianti region of Tuscany, to determine whether resveratrol levels achieved with diet help protect against inflammation, cancer, cardiovascular disease, and death. And the answer is, none of the above. Although annual sales of resveratrol supplements have reached $30 million in the United States alone, there is limited and conflicting human data demonstrating any human benefits, and there are no data concerning its long-term safety.

The exercise study was supported in part by a manufacturer of resveratrol supplements; yet, to their credit, the researchers responded this way to an angry letter by a supplement company consultant: “It is our opinion that we, as scientists, have a responsibility to report what we find, and not to twist our findings to fit the commercial interests.”

To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. This is just an approximation of the audio contributed by Katie Schloer.

Please consider volunteering to help out on the site.

Images thanks to Robert Allen via Flickr.

 

Doctor's Note

What was that about the French Paradox? See my What Explains the French Paradox? video.

The benefits of red wine over white do not appear to be due to the resveratrol, but to the estrogen synthase blockers. Check out Breast Cancer Risk: Red Wine vs. White Wine.

What about the role of red wine in the Mediterranean diet? I have a whole series of videos, including:

Sadly, the epic failure of resveratrol supplements is sadly par for the course when it comes to trying to get your nutrition in pill form. See, for example:

If you haven’t yet, you can subscribe to my videos for free by clicking here.

94 responses to “Resveratrol Impairs Exercise Benefits

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  1. Twas the morning of Christmas

    and I jumped out of bed,

    While others opened presents,

    I opened my computer instead,

    Just had to see the latest

    of what Dr Greger had said.

    While others got toys,

    and trinkets from the mall,

    Knowledge of nutrition,

    is the best gift of all!




    5
    1. Well, im not gonna tell you its a complete health tonic, but i think as a skin tonic the evidence is clear. Everyone that have bad skin should be on it.




      0
  2. I took resveratrol for a while at the suggestion of the book TRANSCEND by Ray Kurzweil and Terry Grossman MD. It seems in hindsight that I wasted a couple hundred dollars because resveratrol supplements are expensive. A less expensive supplement they recommend in this book is alpha lipoic acid, and I’m curious if a future video will offer insight into the efficacy or lack thereof of that supplement.




    0
    1. The difference between resveratrol and alpha lipoic acid is that the latter occurs naturally in the body. The hunan body can make it but if there’s a deficiency, the only food sources that can provide it are animal foods, meaning a vegan has only one choice: supplements.




      1
    2. If you are mercury toxic ALA can be dangerously damaging unless you take it in very small doses at a set schedule based on “frequent dose chelation”.




      0
  3. But what about Polygonum Cuspidatum? As in taking the whole root, not just the extracted resveratrol? And in relation to Lyme, not hart disease.




    0
  4. I’m not convinced that Dr. Greiger is an expert in all the topics he chooses to discuss, at least not the ones I’ve read. I certainly disagree with what he says about Resveratrol and Omega 3’s as these two supplements have helped me and a number of people I know in major ways. They both make me feel better and decrease inflammation in my body, certainly better than glucosamine and chondroitin. I’ve been reading 3 articles or more per day about nutrition for 40 years. The naysayers of health benefits of vitamins and nutrition are often people with some type of political or personal agenda. I can personally say that getting educated about vitamins and minerals, herbs, juicing, and other ways to take care of your body are well worth the time. Don’t take one person’s word for anything. Do your own research.




    0
    1. Well, I agree that one should not rely on a single source for information, and that one should do one’s own research, though I don’t think Dr. Greger is claiming any particular expertise; he’s mainly reporting on recent research. My impression is that he’s pretty thorough but, sure, he may have missed something. And while it’s true that we’re all unique and probably have to find out what works best for us, it’s also good to try and avoid deluding ourselves (I do it all the time !) and sometimes the research just doesn’t support our intuitions.




      0
    2. In fact, Dr. Greger continually counsels his readers not to take his word for anything; he encourages us to investigate the literature ourselves if we can. His interest is in evidence-based nutrition, so if there are indeed well-designed studies supporting the effectiveness of resveratrol or omega 3 fish oil supplements or any other supplement, he would be the first one to want to see them. You should feel free to share them here, in this forum. Nutritionfacts, with its careful listing of source studies, is a premier site for anyone interested, as you are, in helping to be educated in nutrition. It’s all about the science.




      0
      1. In a perfect world, we’d all eat perfect diets day after day everyday and get all the nutrients our bodies need in the right amounts from food. I don’t live in perfect world, so I agree with you; I do need supplements. I choose them carefully and buy the highest quality ones I can afford. My personal case in point is vitamin D. I’m dark skinned and live in an area where the sun shines brightly only about three months of the year. I used to have all sorts of food and environmental allergies. After starting to take vitamin D, the environmental allergies and minor food allergies completely disappeared. (I still have the major food allergies though.)




        0
      2. Problem is, is not all about the science, because that’s usually a moving target. One can easily find credible studies on just about both sides of the debate. Its not like trans fats; very rare is the science conclusive.




        0
    3. Did you even bother to read the citations listed? No you didn’t. I did, at least the abstracts…and guess what. You just got educated by coming here. Choosing to ignore new info…that is entirely up to you.




      0
    4. ” The naysayers of health benefits of vitamins and nutrition are often people with some type of political or personal agenda.”

      … ditto for many proponents … caveat emptor. (I do take some supplements.)




      0
    5. Denise: No one is right about everything. Perhaps resveratrol is one area Dr. Greger just has it wrong. (I’m not saying he does have it wrong. I think this list of studies is pretty compelling. Can you find a set of studies on humans showing the positive effects of resveratrol? I’m just saying it is possible Dr. Greger got this one wrong.)

      But I don’t think you are accurately representing Dr. Greger’s position on omega 3’s. You can easily see what Dr. Greger says about fish oil:
      http://nutritionfacts.org/video/is-fish-oil-just-snake-oil/

      But that’s not the same as saying Dr. Greger is against omega 3 supplementation. In fact, in his new book, Dr. Greger says that omega 3 supplementation where the source is from algae may be a good idea (p 411). I highly recommend checking out the new book!




      0
    6. Another thought from my own experience…the notorious placebo affect can play a huge role. Mostly it is spoken of in a negative light, but it is actually an amazing gift! People have managed to survive diseases that are normally lethal because they believed that they could (whatever their “medicine”) and conversely, healthy people die when they have no hope, as when part of a long term couple are separated by death, etc. Our minds are incredibly powerful if we can harness it! Which is why I don’t have a lot of faith in “placebo controlled studies”…it’s all therapeutic to a degree…or not, depending. Good luck to anyone who tries to design an unbiased study on humans!
      Dr Greger never professed to be an expert on the material he covers, he just makes it accessible to non medical interests. He is one man doing his best, and kudos to him for his caring, sharing, and efforts!




      0
    7. I have to say, I’ve had similar experiences with an omega 3 fish oil supp. In as much a controlled test as I can do, same diet, same lifestyle, etc., on 3 separate occasions I stopped the O3’s, and after 4 to 8 weeks began to notice a difference, so I went back to them. Would flax have given the same benefit? Was it something else in the supp? Dietary? Really I don’t know. I was convinced I didn’t need them, so I doubt it was placebo. All I know is there is a benefit, I feel better with less inflammation/stiffness, my checkups are fine, and my MD is fine with me taking it, so I’ll continue.




      0
    8. Totally agree with Denise. I have medically trained doctors constantly denying the benefits of the many alternative, or complementary products and services available, only to find that they know very little, or nothing about nutrition and supplements. Clinical trials are not the only way to see results. I agree they are the best if you can find someone to fund the study and if you can get a large enough test group. In addition, everybody’s body is different. What works for one, might not work for the next person !!! We are all basically the same, but then we are all very different. That’s why some people have sensitivities and allergies whilst others don’t, etc, etc, etc!!!!




      0
      1. Some people go to stores to buy grape seed extract, which has been shown in studies to help human health. I get it for free in the grapes I grow. Dr. Greger will never advocate eating animal foods, so we need to keep that in mind. Omega 3 is backed by so many studies, but many supplements are old or rotten, so the nutrition is no longer there. I think the skepticism that Dr. Greger recommends is good. How about those heroic scientists who wouldn’t back the “desired outcome” because the science wasn’t there? John




        0
        1. John: re: “Dr. Greger will never advocate eating animal foods,…”
          I don’t agree with this. Dr. Greger has said more than once that if the body of evidence changes and supports eating say steak, then that’s what he will recommend. Also, I either saw it in his new book or heard it in one of the recent interviews: Dr. Greger said something along the lines of, if it takes adding a small bit of bacon to a salad to get someone to eat the salad (and if they wouldn’t eat the salad otherwise), then they should do that. Also here is a video on NutritionFacts letting people know what the healthiest meat is:
          http://nutritionfacts.org/2013/02/28/what-is-the-healthiest-meat/




          0
            1. I remember him saying something like, “…bacon bits. Or even the real thing for that matter.” Not that he was saying bacon is healthy. He was just putting it all into perspective. (And I could be miss-remembering. That’s just what I remember.)




              0
              1. OK, Veganrunner, I had to find it after your comment. So, page 264: “Bac-Os are what are referred to as ultraprocessed foods, bearing no redeeming nutritional qualities or resemblance to anything that grew out of the ground and often containing added garbage. … As a red-light food, it ideally should be avoided, but if the alternative to your big spinach salad with Bac-Os is KFG, then it’s better to have the salad with the Bac-Os. They can be the spoonful of sugar that makes the medicine go down. The same goes for real bacon bits, for that matter.”

                That’s hardly a hard-line, “never ever going to recommend an animal food” stance.




                0
          1. Thea, when you patiently explain to people while i’m blowing my stack at their self-imposed ignorance…I relearn every time that your way is the right way. Eventually some of them reading this site will begin the process to reassess their views. Eventually a few will open the window a crack, do some thinking and, eventually some will understand that it is all up to them, individually to leave the temple and decide what is most likely to be in their own interests. Karl and his protein paradigm may not make it through that window…but some, many will. So, as a former self-imposed SAD eater, thanks to you and your team. I thought it through before it was too late because of your calm and steadfast reply’s. But somehow I still want to say to some folks, RTFlippinM, heh.




            0
            1. Jeewanu: You have totally made my day. I really appreciate the positive feedback.
              And while I don’t always hold my cool as much as I would like, I agree with you that that is the best way to get through to people. And just the best way to be / make the world a better place. (most) Everyone deserves respect. (And thanks for your last sentence as I sometimes feel the same thing. :-) )




              0
          2. I think it is OK if we disagree. He called it the least offensive, not exactly an endorsement. He will say if you have to eat animals, then eat insects. I am not the only one who feels this way, if you have noticed. I have never seen him endorse good tasting animal products, even if 100 other nutrition doctors are unanimous in it. He’s a human being, and he has his point of view. He can declare that it has nothing to do with his beliefs about being a vegan or animal rights, but others are not convinced.
            John




            0
            1. John: I understand your reply and can see why you feel the way you do. I just have to say, however, that I think it is most telling that you used the phrase “good tasting animal products” in a discussion of healthy foods. Also, it’s not a popularity contest. It is about the science.




              0
              1. Hi Thea,
                I respect your opinion. I think if Dr. Greger were being neutral and only about the science, he wouldn’t be suggesting caterpillars and insects as the most likely choices for people who wanted to eat small amounts of animal products. How many people do you know who eat those? Me either.
                John




                0
                1. John: Dr. Greger isn’t saying Americans eat insects (note it is very common in other cultures) or that insects are a ‘likely choice’ for Americans. That’s the point. This site is not about ‘tastiness’ per say (though a truly healthy diet is *very* tasty). This site is about what we can figure out is healthiest for humans. That video is saying that insects are the healthiest meat. If Dr. Greger based his recommendations only on say ethical values of not wanting to harm non-human animals, Dr. Greger would never have shared the science about insects nor stated in black and white that eating small bits of bacon in a salad can be preferable to other choices for making up a healthy diet. He would have just stopped at the comment about Bac-O bits.

                  Based on your posts, I’m guessing that you think a neutral authority would rank the foods you consider tasty so that you can eat the foods you like, but be a bit healthier. In other words, a list like: pig, goat, cow, salmon, cod… in order. But what we learn from this site, based on thousands of studies, is that none of those foods are very healthy. Putting such a list together would be like giving you a ranking of candy: snickers, milky way, jelly beans… You can make a case for Snickers being healthier than jelly beans because … (Actually, I think that’s true that Snickers is technically healthier because they have whole peanuts in them. But that’s not the point.) But none of them are really healthy. Based on the body of evidence, it would be pretty irresponsible to discuss candy in the context of being healthy. Rather, it is better to say what the science says about candy and then let people decide how much of those unhealthy foods people want to include in their diet. It has nothing to do with an anti-sugar philosophy.




                  0
      2. Take note that Resveratrol in isolation and at unnaturally high concentrations may be harmful, but perhaps as it is found naturally in smaller amounts in synergy with other grape phytonutrients you may have a positive benefit. I am not on board with the idea that red wine is a healthful source though due to the alcohol content and may be a possible explanation for the results of the last study cited in this video. Either way, Isolating single nutrients has always been a problem in nutrition science and is rarely successful in terms of clinical applicability.




        0
      3. Thanks Alan, you’re right and my question was leaning towards the rhetorical, though the statements about resveratrol mitigating the effects of exercise raised at least one eyebrow…




        0
        1. One thing we need to realize is that the study was done with an isolated nutrient in a large dose compared to what you would get from grapes and in the grape it comes as it was packaged, no isolation.




          0
  5. There’s so much misinformation out there. I really don’t understand science. I have this bogus idea that science should police itself more. But that science entity doesn’t exist so self-policing is out of the question. Politics and the zeal for money corrupt so many things. Sad!




    0
    1. It is sad Tobias. But if we will eat a Whole Foods Plant Based Diet with plenty pf Fruits and Veggies and make sure we are getting sufficient calories, mainly from starches then we are on the right track. I know that at the age of 60 that it has and is serving me well.




      0
    2. Hi Tobias. To a large extent legitimate science does police itself. The policing takes place by way of the peer review process. In my area of chemistry there are respected journals to which one can submit papers. The papers are not published until they are reviewed by other experts in the field and found worthy of publication. The problem is that people with agendas other than true science can publish whatever they want under the guise of science in other scientific-looking publications. That is why there is so much BS out there.




      0
  6. Pantothenic Acid, Vitamin B5, doubles life expectancy in mice. What effect does it have on humans? There has not been a study to date. PABA can make hair color more youthful in many incidences. Vitamins are known for their safety, efficacy, value, consistency, and fundamentality. They are an investment in your health any one can make. To not take them is more of a risk in almost every case then to take them. There are some vitamins, Niacin, Vitamin C, and Vitamin E that even a well balanced modern diet cannot contain enough of, due to processing and storage considerations.




    0
    1. Along the lines of what you’re saying, Linus Pauling advocated much higher amounts of vitamin C, and so does Dr. Andrew Saul. He has noticed that other primates eat like 10 times the amount of vitamin C that we do, from whole plant foods of course.
      John




      0
      1. Thank you for defending me. Thank you very much. I was saved by high dose Niacin and Vitamin C. They have very much improved my world. My bones are healing on high dose Vitamin D3. I believe strongly in what Dr. Pauling and Dr. Saul say. There are more than 20 articles that related Vitamin C consumption and longevity in pubmed. Dr. Pauling said three grams of Vitamin C could add 25 years to your life. The curves of longevity and Vitamin C consumption collaborate this. Did you know that there is a native American café in the Native American Museum? You can see there menu here: http://www.mitsitamcafe.com/content/menus.asp. A vegan Native American would probably eat pumpkin, blueberries, cranberries, wild rice, corn, squash, and some beans. They would pass on venison, turkey, and bison.




        0
    2. I take supplements but I think that it is important to be clear-eyed about this. Some studies have shown increased mortality among regular supplement users while others have shown no benefit from supplement use eg
      http://link.springer.com/article/10.1007%2Fs00394-008-0706-y
      http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1700400&fileId=S0007114507812049
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030744/

      Also, many supplements may contain synthetic ingredients which are chemically identical but may not be biologically identical to the real thing found in food. Additionally, supplement users end up consuming a lot of magnesium stearate, silica and other fillers etc. Further, users will be consuming gelatin unless they actively choose vegetarian/vegan products. What are the effects of long term consumption of these fillers, synthetic ingredients etc? I don’t believe that this has been studied.

      I think there is a role for carefully chosen supplements especially where a wide variety of produce and other foods is not available, However, let’s not advocate their indiscriminate use. Drs Greger and Fuhrman, and Jack Norris and Ginny Messina, advocate the use of carefully chosen supplements eg
      http://www.veganhealth.org/articles/dailyrecs
      http://nutritionfacts.org/2011/09/12/dr-gregers-2011-optimum-nutrition-recommendations/
      https://www.drfuhrman.com/library/healthydiet_multi.aspx
      http://www.theveganrd.com/2010/11/recommended-supplements-for-vegans.html
      http://www.diseaseproof.com/archives/cat-vitamins-supplements.html




      0
      1. How about GMOs in supplements? Because I’m an nutritional therapist I’m able to buy professional quality supplements from wholesalers. I was shocked a year or so ago to read an article in one of their newsletters that admitted it was difficult to get GMOs out of some supplements. This is because supplements can contain as many as 50 ingredients from many sources. Many vitamins are extracted by fermentation and fermentation often uses GMO corn or sugar beets to feed the microorganisms that are fermenting out the vitamins. Some of the B vitamins, ascorbic acid and beta carotene come from fermentation processes. Soybeans, 94% of which are GMO in this country, are the source of supplemental vitamin E, while corn, also mostly GMO, is the source for most vitamin C. Even vitamin D3 comes primarily from lamb’s wool. In order to use non-GMO labeling, manufacturers have to get verification that the lambs haven’t eaten GMO grains. Strangely enough, L tyrosine comes from human hair and it’s impossible to verify that humans haven’t eaten GMO foods.

        The article I read wasn’t deeply comprehensive, so this is probably the tip of the GMO iceberg. Many manufacturers are scrambling to clear up the supply line in order to have the non-GMO labeling that Whole Foods will require by 2018.




        0
        1. Just what about GMOs are you concerned with? Citations? anything at all? Or is it in your view, as I suspect it is, immoral to change an organism’s genes in a chemistry lab?




          0
          1. IMO…GMOs would be sensibly used in creating specific drugs/therapies…but not in the general food supply along with the associated increase in use of herbicides…etc.




            0
        2. Yes, that’s a point. I prefer to use Garden of Life and New Chapter supplements which are usually vegetarian and non-GMO for that reason. However, I’m not religious about it and take a NOW brand D3+K2 supplement for example.

          From what I’ve read, there are no known harmful effects on humans from consuming GMO foods. But why take the risk … especially when long term studies on humans haven’t been conducted. McDougall puts this position well
          https://www.drmcdougall.com/2013/08/31/gmo-foods-a-potentially-disastrous-distraction/




          0
          1. I’m old enough to remember a time when cigarette smoking was considered safe, even healthful, when doctors recommended their favored brands on the backs of The Saturday Evening Post, Life and other magazines – for a price, of course. Now we know that 90% of lung cancer could be avoided by not smoking.

            There haven’t been any long term tests of GMOs, so, while many choose to ignore any possible dangers, I choose to try and avoid being part of this uncontrolled experiment to the degree possible.




            0
              1. Absolutely. This quote by Alan Watts, long before the study of various microbiomes became hot in science, says it more eloquently than I could:

                “Furthermore, every act of interference with the course of nature changes it in unpredictable ways. A human organism which has absorbed antibiotics is not quite the same kind of organism that it was before, because the behavior of its micro-organisms has been significantly altered. The more one interferes, the more one must analyze an ever-growing volume of detailed information about the results of interference on a world whose infinite details are inextricably interwoven. Already this information, even in the most highly specialized sciences, is so vast that no individual has the time to read it – let alone absorb it.”

                Unfortunately, much of the tinkering with nature is done ONLY for potential profits, without regard to the health of the planet and all the creatures living on it.




                0
    3. I take supplements but I think that it is important to be clear-eyed about this. Some studies have shown increased mortality among regular supplement users while others have shown no benefit from supplement use eg
      http://link.springer.com/article/10.1007%2Fs00394-008-0706-y
      http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1700400&fileId=S0007114507812049
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030744/

      Also, many supplements may contain synthetic ingredients which are chemically identical but may not be biologically identical to the real thing found in food. Additionally, supplement users end up consuming a lot of magnesium stearate, silica and other fillers etc. Further, users will be consuming gelatin unless they actively choose vegetarian/vegan products. What are the effects of long term consumption of these fillers, synthetic ingredients etc? I don’t believe that this has been studied.

      I think there is a role for carefully chosen supplements especially where a wide variety of produce and other foods is not available, However, let’s not advocate their indiscriminate use. Drs Greger and Fuhrman, and Jack Norris and Ginny Messina, advocate the use of carefully chosen supplements eg
      http://www.veganhealth.org/articles/dailyrecs
      http://nutritionfacts.org/2011/09/12/dr-gregers-2011-optimum-nutrition-recommendations/
      https://www.drfuhrman.com/library/healthydiet_multi.aspx
      http://www.theveganrd.com/2010/11/recommended-supplements-for-vegans.html
      http://www.diseaseproof.com/archives/cat-vitamins-supplements.html




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  7. Yes. Dr. Greger knows bacon is strongly linked to cancer. I think everyone does by now. So, the sentence surprised me too–in a way. Which is why it stuck with me. And also why I decided to find that quote if I could. I feel very strongly that if I’m going to quote or say that “so and so said bla bla”, I must get it right. I can’t stand it when people attribute positions to me that simply aren’t true.

    At the same time as that sentence stuck in my head, it also didn’t fully surprise me. Dr. Greger is making a point that I think is consistent with his overall message all along. The paragraph that I quoted gets at the gist of the point, but I recommend people read the whole section. That whole section on “How I Defined ‘Processed'” is vital and so well written.

    I appreciate that Dr. Greger is sticking by his goal of telling people what the science says in regards to human health and nutrition–as far as he interprets it. And then people can use their conscience to decide the if they want to take part in the torture of an animal that is every bit (if not more) sentient, loving and smart as their dog or 1 year old kid.

    (FYI: I *just* got the book. I don’t know why they delivered it to me so many weeks after the release. Maybe because I got so many copies??? I’m only on chapter 2 at the moment. But the first thing I did was flip through and skim a few pages here and there. I just happened to see that page first off. As others have said, I can totally hear Dr. Greger’s voice in my head as I read. It’s kind of funny.)




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  8. Hey doc, please consider doing a whole series on supplements. Like you’ve said, its a multi-billion dollar industry, and I’ll bet most of us here have taken some at one time or another. I am aware that other than B12, you’re against all supps, but we’d still enjoy the info.




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  9. There are other compounds in red wine other than resveratrol, quecertin and rutin. French people also have a higher rate of liver disease due to the alcohol in red wine which nobody talks about.




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  10. Is there a valid study that shows that it is actually the antioxidants that confer the bulk of the health and longevity benefits and not other ingredients in the foods?




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  11. Dr Greger says resveratrol negates the effects of exercise. I have also read that 200mg resveratrol/day will dissolve amyloid plaque in the brain, yet there is no such mention in the Alzheimer’s topic. Anyone have info?




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  12. I have great respect for your work, but I think there is a mistake : “resveratrol levels achieved with diet” it really is “resveratrol levels achieved from RED WINE”.

    I have read the study (involving the Chianti region, Tuscany), and the main source of resveratrol was from red wine. Red wine contain ethyl alcohol (which is a toxic substance) and some resveratrol, taken together, in this case we can expect a better longevity ??!.

    The study say :

    ” In the present study, urinary resveratrol levels were significantly associated with alcohol intake. The study population is located in the wine-growing Chianti region of Tuscany. The moderate high correlation between alcohol intake and urinary resveratrol is most likely attributed to a correlation between wine intake and resveratrol.

    …..

    Alcohol consumption, current smoking, and physical activity were higher among participants in the highest quartile of total urinary resveratrol metabolites compared with the lower quartiles.”

    I think this is not fair. What about resveratrol intake from fruits and vegetables and longevity ?




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  13. I’ve watched a video here that talked about the amount of wine that would be beneficial and showed a U shape curve. I can`t find it again, does anyone knows its name?




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