Mushrooms appear to have an anti-inflammatory effect on human arterial lining cells in vitro, which may help stop the inflammatory cascade thought integral to the progression of atherosclerotic (artery-clogging) heart disease. The effects of shitake, crimini, oyster, maitake and plain white button mushrooms are compared.
We've covered how to prevent the first step of atherosclerosis… Decrease the level of bad cholestol in the blood. What about blocking some of these other steps downstream? “Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment.” So both this step… and this step.
Basically, what these researchers at Arizona State did just took the lining of a human artery, soaked it overnight with either nothing—the control group, or shitake mushrooms, crimini mushrooms, oyster mushrooms, maitake mushrooms or plain white button mushrooms. Then they took away the mushrooms, washed it off and added some monocytes before and after inflammation. So what we’d like to see is these bars come down, less monocyte adhesion, so instead of being sucked in the walls of our arteries they can go off and do their business elsewhere.
Which mushroom do you think worked the best? They all worked, but in another victory for this little funguy, plain-old cheap white button mushrooms worked the best. And under inflammatory conditions they found the same thing, but shitake didn’t seem to work much at all.
“The health implications are that diverse mushrooms, including common and specialty mushrooms can protect against cardiovascular disease by interfering with events that contribute to atherogenesis.”
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Serena
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For more magic from plain white mushrooms, see Vegetables Versus Breast Cancer and Breast Cancer Prevention: Which Mushroom is Best?. Just make sure to cook them (Toxins in Raw Mushrooms?). In terms of anti-inflammatory foods in general, check out Anti-Inflammatory Antioxidants, Garden Variety Anti-Inflammation, Aspirin Levels in Plant Foods, and Dried Apples Versus Cholesterol. In terms of pro-inflammatory foods, see the 4-part series Improving Mood Through Diet, Inflammatory Remarks About Arachidonic Acid, Chicken, Eggs, and Inflammation, and Chicken’s Fate is Sealed. If you missed it, please check out the previous video and any of the other 500 or so videos covering more than a thousand topics.
For some context, please check out my associated blog posts: The Most Anti-Inflammatory Mushroom, Ergothioneine: A New Vitamin?, Plant-Based Diets for Rheumatoid Arthritis, Mushrooms for Breast Cancer Prevention, and Vitamin D from Mushrooms, Sun, or Supplements?