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Making Our Arteries Less Sticky

Mushrooms appear to have an anti-inflammatory effect on human arterial lining cells in vitro, which may help stop the inflammatory cascade thought integral to the progression of atherosclerotic (artery-clogging) heart disease. The effects of shitake, crimini, oyster, maitake and plain white button mushrooms are compared.

June 25, 2012 |
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Acknowledgements

Images thanks to sweetbeetandgreenbean, Jinny Wong, and NASA via Wikimedia Commons.

Transcript

We've covered how to prevent the first step of atherosclerosis… Decrease the level of bad cholestol in the blood. What about blocking some of these other steps downstream? “Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment.” So both this step… and this step.
Basically, what these researchers at Arizona State did just took the lining of a human artery, soaked it overnight with either nothing—the control group, or shitake mushrooms, crimini mushrooms, oyster mushrooms, maitake mushrooms or plain white button mushrooms. Then they took away the mushrooms, washed it off and added some monocytes before and after inflammation. So what we’d like to see is these bars come down, less monocyte adhesion, so instead of being sucked in the walls of our arteries they can go off and do their business elsewhere.
Which mushroom do you think worked the best? They all worked, but in another victory for this little funguy, plain-old cheap white button mushrooms worked the best. And under inflammatory conditions they found the same thing, but shitake didn’t seem to work much at all.
 “The health implications are that diverse mushrooms, including common and specialty mushrooms can protect against cardiovascular disease by interfering with events that contribute to atherogenesis.”

To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Serena

To help out on the site please email volunteer@nutritionfacts.org

Dr. Michael Greger

Doctor's Note

For more magic from plain white mushrooms, see Vegetables Versus Breast Cancer and Breast Cancer Prevention: Which Mushroom is Best?. Just make sure to cook them (Toxins in Raw Mushrooms?). In terms of anti-inflammatory foods in general, check out Anti-Inflammatory Antioxidants, Garden Variety Anti-Inflammation, Aspirin Levels in Plant Foods, and Dried Apples Versus Cholesterol. In terms of pro-inflammatory foods, see the 4-part series Improving Mood Through Diet, Inflammatory Remarks About Arachidonic Acid, Chicken, Eggs, and Inflammation, and Chicken’s Fate is Sealed. If you missed it, please check out the previous video and any of the other 500 or so videos covering more than a thousand topics.

For some context, please check out my associated blog posts: The Most Anti-Inflammatory Mushroom Ergothioneine: A New Vitamin?,  Plant-Based Diets for Rheumatoid ArthritisMushrooms for Breast Cancer PreventionVitamin D from Mushrooms, Sun, or Supplements? , and Mushrooms and Immunity

  • Michael Greger M.D.

    For more magic from plain white mushrooms, see Vegetables Versus Breast Cancer and Breast Cancer Prevention: Which Mushroom is Best?. Just make sure to cook them (Toxins in Raw Mushrooms?). In terms of anti-inflammatory foods in general, check out Anti-Inflammatory Antioxidants, Garden Variety Anti-Inflammation, Aspirin Levels in Plant Foods, and Dried Apples Versus Cholesterol. In terms of pro-inflammatory foods, see the 4-part series Improving Mood Through Diet, Inflammatory Remarks About Arachidonic Acid, Chicken, Eggs, and Inflammation, and Chicken’s Fate is Sealed. If you missed it, please check out the previous video and any of the other 500 or so videos covering more than a thousand topics.

    • HemoDynamic, M.D.

      I always like your Punniness with your comments!!

  • Stefan Juhl M.D.

    Interesting (as always Dr Greger), but I find it a little difficult to extrapolate from this study design to conclude anything about the mushrooms in my veg-lasagne. The concentration “of mushroom” on the intima in the study, is probably several thousand times higher than I can obtain through diet.

    • HemoDynamic, M.D.

      Ah, you may be right Dr. Juhl, but again the key is a Varied. You probably read this but here is a quote from the Study conclusion:

       ”These findings further support the notion that consumption of not only fruits and vegetables, but also dietary fungi, viz., mushrooms, is an important approach to minimizing CVD risk. Moreover, common, readily available and affordable mushrooms such as white button, or Agaricus bisporus, as well as specialty mushrooms including shiitake appear particularly beneficial to health.”

      I wouldn’t want to try the 10% Mushroom diet they spoke about in the study.  I will just use them as I like them. . . A BIG Portabella Mushroom Burger!

      How about this study: A 2009 case control study of more than 2000 women correlated a large decrease of breast cancer incidence in women who consumed mushrooms. Women in the study who consumed fresh mushrooms daily were 64% less likely to develop breast cancer, while those that combined a mushroom diet with regular green tea consumption reduced their risk of breast cancer by nearly 90%.
      http://www.ncbi.nlm.nih.gov/pubmed/19048616
      That is if the statistics are interpreted correctly.

      Enjoy, my friend, a Fungi filled day.

      • Stefan Juhl M.D.

        Thanks. The study is of course interesting, and points in a direction. Does that sentence make sense in english?

        Information from epidemiological studies (e.g. The China Study) is very usefull in recommendations. The study you refer to also sounds very interesting.

        No fungi today – Dark Horse Lentil Soup with brown rice for dinner.

        Found a living beetle in my VEGETARIAN sandwich today. Got the money back…..

        • HemoDynamic, M.D.

          There they go trying to sneek a little animal protein in on ya without you knowing it ;-}
          Oh the Insanity of it all!

          • Stefan Juhl M.D.

            But could they not have killed it first? On the other hand: If they had tried with pork, it would probably also contain a little feces, so I think I would prefer the bug……

        • HemoDynamic, M.D.

          No the sentence didn’t make sense.  When I cut and paste sometimes my sentence gets cut off and I didn’t proof it before posting. 
          I stand corrected!

  • http://poxacuatl.wordpress.com/ Strix

    Dr. G., were the mushrooms used in the studies cooked or raw?

     

    • Stefan Juhl M.D.

      Good question. Problems with raw mushrooms?

    • HemoDynamic, M.D.

      From the study:
      “Harvested mushroom crops were randomly sampled, cleaned, sliced, and stored at 0°C for 24 h. Samples were later freeze-dried (Model 15 SRC-X; Virtis Genesis Co, Inc., Gardiner, NY), ground to a fine powder, and sieved through a 16 mesh screen. Mushroom powders were collected in sterile sample bags (Fisher Scientific, Pittsburgh, PA) and stored in the dark at room temperature in desiccators prior to analysis. After analyses, lyophilized mushroom powders were stored desiccated at -80°C in the dark until use.”http://www.nutritionj.com/content/pdf/1475-2891-9-29.pdfHope this helps

    • Toxins

      We should try to consume mushrooms cooked simply because of some potential toxins found when raw.
      http://nutritionfacts.org/videos/toxins-in-raw-mushrooms/

  • eicosatetraenoic

    Did anyone notice that this study was funded by “a grant from the Mushroom
    Council (San Jose, CA, USA) and the Australian Mushroom Growers
    Association”? Also, DMSO is a curious choice for a vehicle, and it could have interfered with the results.

  • Bhmosman

    The type is so small we can’t read it.

  • http://www.facebook.com/diane.krstulovich Diane Krstulovich

    Good news.  I love mushrooms!

  • Dr Jim

    WOW! Who would have “thunk” that the white buttons beat out the shitake?! It’ll save me future expenses…….Dr.Jim

  • Raven

    The english journel of medicine – says that there is NO good Colestrol that is a mistake and that we need to watch both numbers…. what about that? So American medicine is behind on this?

  • Kate

    I am so glad I,ve found this site, I have been ill now since 1995, had a lot of illness one after another Unlucky me, now I am waiting on gallstone operation. Hope I can benefit from Dr. Greger’s Notes, and though diet and knowledge I’ll fined someway to help make my health better, he,s giving me a lot of reading to do, but it, great to fine at last a website that gives you in sites to all illness, as I can do more research into helping me build a better healthily way to a new life.