Avocado

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The Effect of Avocados on Small, Dense, LDL Cholesterol

What are the effects of oatmeal, walnuts, extra virgin olive oil, and avocados on LDL cholesterol size? 

When a headline reads “Avocados could improve your cholesterol—and more,” the article and others like it are largely talking about substitution experiments, where avocado is added to the diet as a replacement for animal fats. In that case, it’s no wonder cholesterol goes down. Dairy and poultry are the two greatest contributors of cholesterol-raising saturated fat intake, so if you take people eating a standard North American diet including animal fats, they may start out with an LDL cholesterol level up around 95mg/dl. If you add avocado to their diet without doing anything else, their cholesterol does not go down; instead, it may go up to around 105mg/dl. If you add avocado while reducing saturated fat intake, though, cholesterol falls to about 90mg/dl—but that drop isn’t very different from what you’d get by just reducing saturated fat and adding nothing, which was shown to give an LDL under 90mg/dl, as you can see at 0:34 in my video Avocados Lower Small Dense LDL Cholesterol

What if you compared the effects of eating no meat at all with a meat-free diet that included avocado? Researchers took people with sky-high cholesterol levels up around 300mg/dl and switched them to either a relatively low-fat vegetarian diet with about 20 percent of calories from fat or a vegetarian diet with added avocado that took it up about 30 percent of calories from fat, which is a more typical fat content. As you can see at 1:22 in my video, the study participants started out with LDLs through the roof, and, while cutting out meat may have helped, cutting out meat and adding avocado seemed to help even more—and it may help best with the worst type of LDL.  

As I’ve touched on before, all LDL cholesterol is bad cholesterol. However, large, fluffy LDL may only increase the odds of cardiac events such as heart attacks by 31 percent, whereas small, dense LDL is even worse and increases the odds by 44 percent.  

If you feed people a lot of oatmeal and oat bran, not only does that cause their LDL to go down overall, but it specifically brings down the small LDL, the worst of the worst. What happens if you add walnuts to a low-fat diet? As you can see at 2:04 in my video, LDL goes down and, at the same time, the size distribution of the LDL shifts to be a little more benign. What if you put people on a plant-based diet with lots of fiber and nuts? As shown as 2:15 in my video, you can get a massive 30 percent drop in LDL, a drop that is comparable to a cholesterol-lowering statin drug. What’s more, this includes a drop in the small, dense LDL, which is the most dangerous.  

This does not happen with extra-virgin olive oil, however, so it’s not just a monounsaturated fat effect. In the famous PREDIMED study, which you can see at 2:35 in my video, those randomized to the extra nuts group got a significant drop in the smallest, densest LDL, but those randomized to the extra-virgin olive oil group did not. So, there appears to be some special components in nuts that lowers the worst of the worst LDL cholesterol.  

Do avocados offer similar benefits? We didn’t know until the first randomized controlled feeding trial to look at avocados and LDL size. The researchers removed animal fat from people’s diet and replaced it with either carbohydrates, avocado, or vegetable oils that had a similar fat profile to the avocados. In this way, the avocado group and the vegetable oil group were put on very similar diets, except one had the nutrients unique to avocados and the other did not.  

What happened? 

Any time you lower intake of saturated fat, such as replacing animal fat with plant fat (vegetable oil in this case) or carbohydrates, you’re going to bring down LDL. Okay, but does replacing animal fat with the whole plant food avocado make a difference? Yes. That resulted in an even better effect. To see why, the researchers broke the LDL down into large versus small. All three treatments brought down the dangerous large LDL, but the avocado had the additional effect of also bringing down the super dangerous small LDL. That’s where that extra drop came from. You can see a graph depicting these findings at 3:27 in my video

 So, it’s not just a matter of replacing animal fat with plant fat. There are additional benefits to the fiber and phytonutrients of whole plant foods like avocados. 

If there’s something good in avocados, should we just add avocado extracts to meat? Well, incorporating avocado extracts into pork patties evidently reduces the meat’s cholesterol oxidation products that “have been well documented” to be toxic, carcinogenic, and atherosclerotic, but it doesn’t eliminate them. 

KEY TAKEAWAYS

  • Dairy and poultry are two of the most significant contributors of cholesterol-raising saturated fat in the diet.
  • Simply adding avocado to the diet without also reducing saturated fat intake does not appear to lower cholesterol and, in fact, may cause it to rise.
  • Substitution experiments, where avocado replaces animal fats in the diet, have shown improvements in cholesterol, however, the drop does not appear to differ much from just reducing saturated fat consumption without adding anything else.
  • Comparing the effects of a meat-free diet to a meat-free diet with added avocado, researchers found that eschewing meat while also adding avocado helped even more than merely skipping meat, and it may help more effectively with the worst type of bad LDL cholesterol, small, dense LDL.
  • Oatmeal, oat bran, walnuts, and a plant-based diet rich in fiber and nuts have all been shown to cause LDL to lower overall and the more dangerous, small LDL, specifically, but this was not seen with extra-virgin olive oil, suggesting it is not only a monounsaturated fat effect.
  • Researchers removed animal fat from subjects’ diets and replaced it with either carbohydrates, avocado, or vegetable oils with similar fat profiles to avocados and found that replacing the animal fat with the whole plant food avocado had the best results in reducing LDL.
  • All three treatments lowered large LDL, but avocado had the added effect of also lowering the more dangerous small LDL.

What about the effects on cholesterol of people not consuming plant-based diets? See my video Are Avocados Good for Your Cholesterol?. 

 For more information on large, fluffy LDL versus small, dense LDL, check out Flashback Friday: Does Cholesterol Size Matter?.

And, if you love avocados as much as I do, you may be interested in: 


In health, 

Michael Greger, M.D. 

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live presentations: 

 

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Michael Greger M.D., FACLM

Michael Greger, M.D. FACLM, is a physician, New York Times bestselling author, and internationally recognized professional speaker on a number of important public health issues. Dr. Greger has lectured at the Conference on World Affairs, the National Institutes of Health, and the International Bird Flu Summit, testified before Congress, appeared on The Dr. Oz Show and The Colbert Report, and was invited as an expert witness in defense of Oprah Winfrey at the infamous "meat defamation" trial.


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