Did the five randomized controlled trials of reishi mushrooms in cancer patients show benefits in terms of tumor response rate, survival time, or quality of life?
Medicinal Mushrooms for Cancer Survival
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
Can mushrooms be medicinal? Mushroom-based products make up a sizable chunk of the $50 billion supplement market. “This profitable trade provides a powerful incentive for companies to test the credulity of their customers and [sadly] unsupported assertions have come to define the medical mushroom business.” For example, companies that market herbal medicines exploit references to studies on mice to promote their mushroom capsules for treating all kinds of ailments. But, if you haven’t noticed, we’re not mice.
I mean, it wouldn’t be surprising if mushrooms had some potent properties. After all, fungi are where we got a bunch of drugs, not the least of which is penicillin, also a cholesterol-lowering drug lovastatin, and the powerful immunosuppressant drug cyclosporin. Still don’t think a little mushroom can have pharmacological effects? Don’t forget they can produce some of our most powerful poisons. Some kind of look the part, like the toxic Carolina false morel, all toadstooly and such, but others have more of an angelic look, indeed, literally called the destroying angel (that’s its name), and as little as a teaspoon can cause a painful, lingering death.
So anyway, we should have respect for the pharmacological potential of mushrooms, but what can they do that’s good for us? Well, consuming shiitake mushrooms daily improves human immunity. Giving people just one or two dried shiitake mushrooms a day (about the weight equivalent of five to ten fresh ones) for four weeks resulted in an increase in proliferation of gamma-delta T lymphocytes, and doubled the proliferation of natural killer cells. Gamma-delta cells act as a first line of immunological defense. And even better, natural killer cells kill cancer, and the shiitake did all this while lowering markers of systemic inflammation.
Oyster mushroom extracts don’t seem to work as well, but what we care about is if mushrooms can actually affect cancer outcomes. Shiitakes haven’t been tried yet, but reishi mushrooms have, after being used as a cancer treatment throughout Asia for centuries.
Reishi mushroom for cancer treatment: What does the science say? A meta-analysis of five randomized controlled trials showed that patients who had been given reishi mushroom supplements along with chemo/radiation were more likely to respond positively compared to just chemo/radiation alone. Although adding a reishi mushroom extract improved tumor response rates, the data failed to demonstrate a significant effect on tumor shrinkage when the mushrooms were used alone. So, they aren’t recommended as a single treatment, but rather an adjunct treatment for patients with advanced cancer.
“Response rate” just means the tumor shrinks. What we care about is whether or not it actually improves survival or quality of life. and we don’t have convincing data suggesting reishi mushroom products improve survival. But those randomized to reishi were found to have a relatively better quality of life; so, that’s a win as far as I’m concerned.
What about other mushrooms? Although whole shiitake mushrooms haven’t been tested yet, there’s a compound that’s extracted from shiitakes called lentinan, which is said to have completely inhibited the growth of a certain kind of sarcoma in mice. But in actuality, it only worked in one single strain of mice, and failed in nine others. So, are we more like the 90 percent of mouse strains in which it didn’t work? We need human trials, and we finally got them. There are data on nearly 10,000 cancer patients who have been treated with the shiitake mushroom extract injected right into their veins. What did the researchers find? We’ll find out next.
Please consider volunteering to help out on the site.
- Money NP. Are mushrooms medicinal?. Fungal Biol. 2016;120(4):449-53.
- Litten W. The most poisonous mushrooms. Sci Am. 1975;232(3):90-101.
- Lim CS, Chhabra N, Leikin S, Fischbein C, Mueller GM, Nelson ME. Atlas of select poisonous plants and mushrooms. Dis Mon. 2016;62(3):41-66.
- Culliton BJ. The destroying angel: a story of a search for an antidote. Science. 1974;185(4151):600-1.
- Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87.
- Tanaka A, Nishimura M, Sato Y, Sato H, Nishihira J. Enhancement of the Th1-phenotype immune system by the intake of oyster mushroom (Tamogitake) extract in a double-blind, placebo-controlled study. J Tradit Complement Med. 2015;6(4):424-30.
- Popović V, Živković J, Davidović S, Stevanović M, Stojković D. Mycotherapy of cancer: An update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action. Curr Top Med Chem. 2013;13(21):2791-806.
- Jin X, Ruiz Beguerie J, Sze DM, Chan GC. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2012;(6):CD007731.
- Ivanova TS, Krupodorova TA, Barshteyn VY, Artamonova AB, Shlyakhovenko VA. Anticancer substances of mushroom origin. Exp Oncol. 2014;36(2):58-66.
- Zákány J, Chihara G, Fachet J. Effect of lentinan on tumor growth in murine allogeneic and syngeneic hosts. Int J Cancer. 1980;25(3):371-6.
- Zhang M, Zhang Y, Zhang L, Tian Q. Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China. Prog Mol Biol Transl Sci. 2019;163:297-328.
Video production by Glass Entertainment
Motion graphics by Avo Media
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
Can mushrooms be medicinal? Mushroom-based products make up a sizable chunk of the $50 billion supplement market. “This profitable trade provides a powerful incentive for companies to test the credulity of their customers and [sadly] unsupported assertions have come to define the medical mushroom business.” For example, companies that market herbal medicines exploit references to studies on mice to promote their mushroom capsules for treating all kinds of ailments. But, if you haven’t noticed, we’re not mice.
I mean, it wouldn’t be surprising if mushrooms had some potent properties. After all, fungi are where we got a bunch of drugs, not the least of which is penicillin, also a cholesterol-lowering drug lovastatin, and the powerful immunosuppressant drug cyclosporin. Still don’t think a little mushroom can have pharmacological effects? Don’t forget they can produce some of our most powerful poisons. Some kind of look the part, like the toxic Carolina false morel, all toadstooly and such, but others have more of an angelic look, indeed, literally called the destroying angel (that’s its name), and as little as a teaspoon can cause a painful, lingering death.
So anyway, we should have respect for the pharmacological potential of mushrooms, but what can they do that’s good for us? Well, consuming shiitake mushrooms daily improves human immunity. Giving people just one or two dried shiitake mushrooms a day (about the weight equivalent of five to ten fresh ones) for four weeks resulted in an increase in proliferation of gamma-delta T lymphocytes, and doubled the proliferation of natural killer cells. Gamma-delta cells act as a first line of immunological defense. And even better, natural killer cells kill cancer, and the shiitake did all this while lowering markers of systemic inflammation.
Oyster mushroom extracts don’t seem to work as well, but what we care about is if mushrooms can actually affect cancer outcomes. Shiitakes haven’t been tried yet, but reishi mushrooms have, after being used as a cancer treatment throughout Asia for centuries.
Reishi mushroom for cancer treatment: What does the science say? A meta-analysis of five randomized controlled trials showed that patients who had been given reishi mushroom supplements along with chemo/radiation were more likely to respond positively compared to just chemo/radiation alone. Although adding a reishi mushroom extract improved tumor response rates, the data failed to demonstrate a significant effect on tumor shrinkage when the mushrooms were used alone. So, they aren’t recommended as a single treatment, but rather an adjunct treatment for patients with advanced cancer.
“Response rate” just means the tumor shrinks. What we care about is whether or not it actually improves survival or quality of life. and we don’t have convincing data suggesting reishi mushroom products improve survival. But those randomized to reishi were found to have a relatively better quality of life; so, that’s a win as far as I’m concerned.
What about other mushrooms? Although whole shiitake mushrooms haven’t been tested yet, there’s a compound that’s extracted from shiitakes called lentinan, which is said to have completely inhibited the growth of a certain kind of sarcoma in mice. But in actuality, it only worked in one single strain of mice, and failed in nine others. So, are we more like the 90 percent of mouse strains in which it didn’t work? We need human trials, and we finally got them. There are data on nearly 10,000 cancer patients who have been treated with the shiitake mushroom extract injected right into their veins. What did the researchers find? We’ll find out next.
Please consider volunteering to help out on the site.
- Money NP. Are mushrooms medicinal?. Fungal Biol. 2016;120(4):449-53.
- Litten W. The most poisonous mushrooms. Sci Am. 1975;232(3):90-101.
- Lim CS, Chhabra N, Leikin S, Fischbein C, Mueller GM, Nelson ME. Atlas of select poisonous plants and mushrooms. Dis Mon. 2016;62(3):41-66.
- Culliton BJ. The destroying angel: a story of a search for an antidote. Science. 1974;185(4151):600-1.
- Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87.
- Tanaka A, Nishimura M, Sato Y, Sato H, Nishihira J. Enhancement of the Th1-phenotype immune system by the intake of oyster mushroom (Tamogitake) extract in a double-blind, placebo-controlled study. J Tradit Complement Med. 2015;6(4):424-30.
- Popović V, Živković J, Davidović S, Stevanović M, Stojković D. Mycotherapy of cancer: An update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action. Curr Top Med Chem. 2013;13(21):2791-806.
- Jin X, Ruiz Beguerie J, Sze DM, Chan GC. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2012;(6):CD007731.
- Ivanova TS, Krupodorova TA, Barshteyn VY, Artamonova AB, Shlyakhovenko VA. Anticancer substances of mushroom origin. Exp Oncol. 2014;36(2):58-66.
- Zákány J, Chihara G, Fachet J. Effect of lentinan on tumor growth in murine allogeneic and syngeneic hosts. Int J Cancer. 1980;25(3):371-6.
- Zhang M, Zhang Y, Zhang L, Tian Q. Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China. Prog Mol Biol Transl Sci. 2019;163:297-328.
Video production by Glass Entertainment
Motion graphics by Avo Media
Republishing "Medicinal Mushrooms for Cancer Survival"
You may republish this material online or in print under our Creative Commons licence. You must attribute the article to NutritionFacts.org with a link back to our website in your republication.
If any changes are made to the original text or video, you must indicate, reasonably, what has changed about the article or video.
You may not use our material for commercial purposes.
You may not apply legal terms or technological measures that restrict others from doing anything permitted here.
If you have any questions, please Contact Us
Medicinal Mushrooms for Cancer Survival
LicenseCreative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Content URLDoctor's Note
Stay tuned for White Button Mushrooms for Prostate Cancer.
For more on mushrooms, see Breast Cancer vs. Mushrooms and Is It Safe to Eat Raw Mushrooms?.
If you haven't yet, you can subscribe to our free newsletter. With your subscription, you'll also get notifications for just-released blogs and videos. Check out our information page about our translated resources.