Pomegranate vs. Placebo for Prostate Cancer

Image Credit: Peggy und Marco Lachmann-Anke / Pixabay. This image has been modified.

Pomegranates Put to the Test for Prostate Cancer

The pomegranate “has been revered through the ages for its medicinal properties”––so much so that it’s been used as a symbol for some medical organizations. A fruit seems to me a better representation of health than the American Medical Association’s snake on a stick.

The pomegranate is thought to be beneficial for a wide range of diseases, including several types of cancer, cardiovascular disease, and rheumatoid arthritis. Evidently even the cannibals love it as it improves the color of “kid meat.” The researchers were talking about baby goats, but the title of their study did make me do a double-take!

Most of the attention over the last decade has focused on pomegranates and prostate cancer. In vitro studies have shown that pomegranate extract can suppress the growth of prostate cancer cells in a petri dish by up to 95 percent. As you can see in my video Pomegranate vs. Placebo for Prostate Cancer, there is no real difference between what normal prostate cells look like under a microscope with a little or a lot of pomegranate extract; it doesn’t seem to have much of an effect on healthy cells. However, prostate cancer cells are decimated by pomegranate extract—at least in a petri dish, but what about in a person? If these results translated to the clinic, it could be dramatic, but we first need to try it out in people.

“Primary management of prostate cancer…consists of either radical surgery or radiation therapy.” Despite this, “a significant number of patients relapse and ultimately develop metastatic disease.” Even after radical prostatectomy, the cancer comes back in about one-third of the patients, as evidenced by rising prostate-specific antigen (PSA) levels. At that point, the treatment options are limited as the prostate has already been removed. The next step is essentially chemical castration, or hormonal ablation. Just like breast cancer can thrive on estrogen, prostate cancer can thrive on testosterone. We can try to wipe out testosterone, but that can have such negative side effects that anything we can do to delay that would be good. 

So, what about plants? Men in Asia appear to have the lowest prostate cancer rates in the world, up to ten times lower than men in North America. Is this simply because of genetics? No. When Japanese individuals move to the United States and start living and eating like us, their breast and prostate cancer rates shoot right up toward ours. It could be because of what they start eating more of: animal products, which are the strongest risk factor for prostate cancer worldwide on a country-by-country basis. Or, it could be because of what they’re eating less of in the United States, namely their traditional low-fat, high-fiber, generally plant-rich diet with soy products and green tea. So, did the researchers put the cancer patients on a plant-based diet? No, they just had them drink a cup of pomegranate juice every day. Why? Because the study was funded by a pomegranate juice company.

In the three years leading up to the study, participants’ cancer was steadily growing, as measured by the increase in their average PSA levels. Once they started the juice, their tumors continued to grow, but it looked like they were growing slower. In contrast, Dean Ornish and his colleagues got an apparent reversal in early prostate cancer growth with a plant-based diet and other healthy lifestyle changes. Indeed, PSA didn’t just go up slower—it trended down. And, when dripping the blood of the men on prostate cancer cells growing in a lab, the blood serum of those eating healthfully suppressed cancer growth nearly eight times better, whereas the blood of the men on the pomegranate juice suppressed cancer growth by only about 12 percent. Still, to see any effect from drinking a cup of juice a day is pretty impressive.

The problem is that there was no control group in the pomegranate juice study. We could say the patients acted as their own controls, before and after. It’s probably not just a coincidence that their tumors started growing slower right when they started the juice. But, a drug trial tried to do the same thing—treat men with recurring prostate cancer after surgery or radiation. In the drug group, tumor growth slowed in 55 percent of the men. A pretty effective drug, right? Well, the sugar pill worked 73 percent of the time. The placebo effect can be so powerful that it may slow cancer growth. This is why we need placebo-controlled trials. Maybe tricking people into drinking pomegranate-flavored Kool-Aid would have had the same effect. We don’t know until we put it to the test.

Finally, researchers did a randomized, controlled trial of pomegranate juice for prostate cancer, and the daily pomegranate intake had no impact. What do they mean, no impact? Twenty-five percent of the cancer patients appeared to shrink their tumors as soon as they started drinking the pomegranate juice, but 35 percent shrunk their tumors not drinking pomegranate juice. So, any effect appears just to be a placebo. It’s the same story with pomegranate extract pills: They seemed to work until they went head to head with sugar pills and fell flat on their face.


I love pomegranates! Unfortunately, the juice and extracts look no more promising today than when I produced my video Is Pomegranate Juice That Wonderful?.

For some foods that may actually affect prostate cancer progression, see:

In health,
Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live, year-in-review presentations:

Discuss

Michael Greger M.D., FACLM

Michael Greger, M.D. FACLM, is a physician, New York Times bestselling author, and internationally recognized professional speaker on a number of important public health issues. Dr. Greger has lectured at the Conference on World Affairs, the National Institutes of Health, and the International Bird Flu Summit, testified before Congress, appeared on The Dr. Oz Show and The Colbert Report, and was invited as an expert witness in defense of Oprah Winfrey at the infamous "meat defamation" trial.


61 responses to “Pomegranates Put to the Test for Prostate Cancer

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  1. I am wondering why the males in Jamaica have such high levels of Prostate Cancer. They used to be #1 is what a site said. I think they were #7 on the WHO site.

    Okay, so Pomegranate juice didn’t work.

    Now I have to go find that synergy study where they added 4 things together. I thought Pomegranate was one, but that was a while back.

    1. Barb,

      Yes, I did.

      I understand that WFPB and a wide variety is better than adding in a few things, but I am literally surrounded by people who it would be a miracle if I could get them to do anything at all and I got my brother whose PSA is high to eat 15 pomegranate seeds and I don’t want him to back up from them as useless. I want him to add a spoonful of turmeric.

      1. Barb,

        The people around me do not eat fruits or vegetables. Almost any.

        My brother likes spinach, but he has one kidney now and I am not wanting him to try to do WFPB and eat only spinach.

        I was watching a video of a woman who did that and she ended up with her kidney beginning to fail and then left veganism as a dangerous diet.

        I watched another woman who switched from vegan to carnivore and nowadays, there are so many people “influencing” people in every ridiculous direction.

        But, they are “getting rid” of things. That woman, it sounds like she did have something like SIBO or Autoimmune and now that she eats no plants and no grains and no beans, she doesn’t feel sick and stopped having eczema etc. and, in truth, she succeeded at getting rid of her digestive disorders and got rid of her skin condition.

        I got rid of mine going off meat decades ago. I am fascinated by that.

        No, I could not ever go carnivore. But I want to understand the improvement people like her have. Her anxiety and things like that went away. I am not sure if she was a junk food vegan or was raw.

        I have spoken in person to people considering going carnivore. I feel like I basically did that when I went Atkins as a young person. It was nice to never feel hungry, but what I remember was that I did struggle staying on it eventually and that my friend’s step-father died a symbolic 2-seconds after losing all of his weight on Atkins and he was in such a happy emotional and mental place and had all these up-lifting goals with his new body, but he didn’t get to do any of them.

        Anyway, I am more concerned with the community at large. The average American SAD male 50’s to early 70’s with high PSA. I think they have said that the number of males who get it eventually is pretty high.

        Yes, I would love it if my brothers suddenly ate WFPB, but it is way more likely that they will successfully introduce a few foods and those foods may displace other things and having his PSA high and also having kidney cancer didn’t make my brother want to eat differently at all.

        1. Of course I wish your family all the best Deb, and I see your point. Certainly the idea of adding one thing to a diet is a lot less overwhelming than doing a total nutritional overhaul. But I was reading Dr Greger’s words this morning thinking of you, and me, and others who are seeking to improve/maintain our cognitive function, as well as keeping cancer, heart disease, diabetes etc at bay. We’re on the right path at least, and you are setting a wonderful example for your family.

          1. Barb,

            That is so sweet of you to say.

            I was watching the woman who switched to carnivore and what I know is that this is a real war.

            That woman left plant foods for all of the reasons I went onto them and she is intentionally using the same language and parallel sentences.

            I think they are doing neurolinguistic programming which I never took, but witch was big in California because it is how you trick people into changing their minds.

            The woman was using exact sentences that the vegan community used down to being emotionally more connected to her food.

            It is creepy that everybody wants to manipulate everybody else.

            Trying to keep using logic when millions of people are out there intentionally trying to destroy logic and they are using the same words and parallel sentences makes it harder to really understand who to trust.

            I think it is like the counterfeit bill where the people who are best at recognizing them spend enough time with genuine bills.

          2. Barb,

            After I ate my Kale, Arugula, Cauliflower, Baby Carrot and pomegranate seed salad with Ginger Miso no oil dressing and a bottle of cold pressed Beet juice and before I ate my blueberries and golden milk and cacao in unsweetened cashew or almond yogurt (I have been alternating)

            I came here inspired by your comment and went back and watched the synergy video again and I read the transcript this time and I saw the word I glossed over last time:

            “Because you can’t stuff a pomegranate in a pill…… researchers tried powdering it. 199 men with prostate cancer either got a placebo or a tablet, three times a day, containing 100mg of whole powdered pomegranate. Now, this was the whole fruit, just with the water taken out. But even so, how much can you fit in a tablet? Comes out to be about six pomegranate seeds’ worth a day. That’s about 1/100 of a pomegranate a day!

            Since they could fit so little in a pill, they tried to maximize their chances of beating back the cancer using diversity. If you have two groups of people eating approximately the same amount of fruits and vegetables, but one group ate a relatively low biological diversity diet, where they ate tons of really healthy foods, but just less variety than smaller servings of a high-diversity diet, which group would win in terms of protecting their DNA from free radical damage? The high-diversity group. This suggests that “smaller amounts of many phytochemicals may have a greater potential to exert beneficial effects than larger amounts of fewer phytochemicals.”

            Same result for inflammation. Greater variety in fruit and vegetable intake is associated with lower inflammation, even if you eat the same number of servings. Same with improving cognitive function. “[G]reater variety in fruit and vegetable intake was associated with a better [mental status], executive function, attention, [and] memory function [in some cases]—even after adjustment for total quantity.”

            So, if you have two people eating the same number of servings of healthy foods, the one eating a greater variety may do better. So, the researchers didn’t just put in some pomegranate powder, they added some powdered broccoli too, and some powdered turmeric, and some powdered green tea concentrate. So, a fruit, a vegetable, spice and leaf, but tiny amounts—that’s like one floret of broccoli a day, less than an eighth-teaspoon a day of turmeric, and about one-sixth of a tea bag worth of green tea. All great plants, but could such tiny amounts actually affect the progression of cancer?

            Yes. In the group of men with early-stage prostate cancer trying to avoid surgery, the PSA levels rose in the placebo group; rose nearly 50%—indicating the cancer continued to flourish, whereas in the pomegranate/broccoli/turmeric/green tea Food Supplement group, the PSAs didn’t rise at all. And, in those with more advanced disease—already had surgery or radiation, and trying to avoid chemo—a 70% greater rise in the placebo group. That was enough to significantly delay some of the more toxic treatment. So, significant short-term, favorable effects—see, they only had enough money to run the study for six months, because it was a non-commercial endeavor, funded by charity. This wasn’t some supplement company—in fact, there was no supplement until the investigators dreamed it up from scratch.”

            Yes, I just posted the study here because it is so ridiculously inspiring to some of us who couldn’t fit the broccoli sprouts in the bowl. I will eat them with a tablespoon of hummus because of re-reading this. I almost didn’t eat my broccoli sprouts.

            Yes, there is a sentence about memory and executive function and I want you all to know that my executive function is improving and my social anxiety still seems pretty low. Sleep is back to medium, but when I actually lay down with my Micropulse ICES, I do still sleep, except for one night. Even two handfuls of pistachios didn’t work. I did buy some kiwis tonight, but I bought the golden kind. I couldn’t tell which one was healthier. I am thinking yellow, but I understand the black and red and orange better and I regretted buying the gold because the study would have been green and if I am going to try their sleep study, I should have bought the right stuff.

            Anyway, my dog is still alive. My brother is still alive. My sister-in-law’s mother is still alive. My sister-in-law who fell may possibly not have been as injured as they thought and my 90-year-old uncle looks like a 70-year-old. He is doing so well. And my brain is healing one area at a time. I am sleeping over 4 hours a night generally. I don’t have social anxiety since the broccoli sprout / ICES experiment.

            And the sweet woman at JKat who sells the chlorine dioxide animal products sent me a box of stuff free. If you ever have a dog who has ringworm or a wound of any kind, I recommend JKat. Sorry for the sales pitch. She just is such a sweetheart.

            1. 6 pomegranate seeds, one floret of broccoli a day, less than an eighth-teaspoon a day of turmeric, and about one-sixth of a tea bag worth of green tea

              THAT is SO INSPIRING.

              I am going to give my ten cents and pre-apologize for being nit-picky, which I am not trying to be.

              I read the comment by Michael below and I feel like this pomegranate one wasn’t as inspiring as the synergy pomegranate one. I feel like you do the balance pretty well, but I feel like the synergy one is so much more useful and like the “It doesn’t work” one might actually get people to go into the medical mindset unless they can go all the way over to WFPB.

              I think you are wonderful and I know I give feedback and comments and talk circles around you. My brain is improving and I haven’t heckled you in a long, long time, but I am putting a suggestion in the comment section and I will call it: Notice how much more inspiring and/or useful this one is versus that.

              1. I am certain that I also needed to know what you wrote above.

                So, if you don’t bear witness to what I said, that is okay.

                I guess I feel like I could actually get my brother to eat a broccoli floret and 6 pomegranate seeds and drink a 1/6 of a glass of green tea and put a tiny bit of turmeric in his food.

                That feels reachable even for my SAD relatives.

                1. The synergy study is one I will share with my friends whose children hate vegetables and fruit.

                  Getting them to eat 6 pomegranate seeds and 1 broccoli floret and a tiny bit of turmeric every day doesn’t even feel difficult at all.

                  Mothers need to hear that study.

            2. I second B’Healthy’s thanks for the update Deb! I will bookmark this page to look back and read often. Great stuff, and I mean that. It’s a real joy to read how everyone is doing well, your dinner is awesome, lol, and thank you too for the eloquent recap of the “diversity wins’ point Dr Greger was making. (I am eating greens daily but havent had spinach in over a week :)

            3. Deb

              Yes but where is the actual study?

              Nothing personal but I have seen people write all sorts of things about studies. However, upon checking, it often turns out that there are differences between the poster’s description and what the paper actually says.

  2. I have seen several studies that indicate that pomegranate juice is good for arterial health. See:

    https://www.lifeextension.com/magazine/2007/5/report_pomegranate/Page-01

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678830/

    https://www.ncbi.nlm.nih.gov/pubmed/15158307

    I’m puzzled by focusing on things for which pomegranate juice is not effective while ignoring things for which it IS effective (at least according to the two studies linked above).

    Why no comment on pomegranate juice and arterial health?

      1. Thanks for the quick response. I did view the video to which you linked, and I saw only one false claim, and that was not in the research report but was made by the POM Wonderful company. I didn’t see any other false claims, just the one, and as I said it was in advertising copy, not a research report.

        I gave links to two research reports that support pomegranate juice’s benefits for arterial health, but so far as I can tell you did not look either report (or at the article to which I linked).

        From the abstract of the first research report: “… pomegranate is superior in comparison to other antioxidants in protecting low-density lipoprotein (LDL, “the bad cholesterol”) and high-density lipoprotein (HDL, “the good cholesterol”) from oxidation, and as a result it attenuates atherosclerosis development and its consequent cardiovascular events”

        The title of the second research report: “Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.”

        Dr. Greger did not address the findings of either of these research reports. And again, I was able to find only one false claim. Could you point out those that I missed? That would be helpful.

        1. I will tell you that I have seen those studies years ago and every day I would give my grandmother a small glass of pomegranate juice and she would look up at me as if she didn’t want to drink it and I would say, “Gram, you have to take your medicine.” And she would drink it and shake her head and squinch her mouth and eyes. But she took it every single day.

          I eat the berries every day. I can’t the stand the juice either and didn’t know that the berries could be better.

          1. I did get one man to try the pomegranate juice and he did it for the length of the study. He didn’t go get tested to see if there was a difference.

            He said to me, “It didn’t lower my blood pressure at all and I felt like it was an expensive waste of time.”

            Since then, he watched a different video I also sent to him and he has lowered his blood pressure by changing his whole diet. He isn’t exactly WFPB. Maybe more the Mediterranean. But his blood pressure has changed considerably. He cut way back on pizza and lowered the portion size of his meat and got mostly off of beer.

      2. Barb, did you see my reply?

        1. You mentioned “false claims,” but I was able to find only one. What are the other(s)?

        2. I listed two studies that support pomegranate’s benefits for arterial health, including the URLs. You have not responded. Did you see those studies?

        1. They are in fact two studies by the same Israeli team which, unsurprisingly, reached similar conclusions. As far as I can tell, the studies were neither randomised nor blinded, nor was PJ tested against a placebo. Further, Israel is a major producer and exporter of pomegranates.

          A degree of caution is probably warranted I’d say.

          1. Let’s just note also that, when a randomised double blinded study was conducted, it concluded that

            ‘in subjects at moderate coronary heart disease risk, pomegranate juice consumption had no significant effect on overall CIMT progression rate’
            https://www.ncbi.nlm.nih.gov/pubmed/19766760

            As for the first article you linked to, LEF sells pomegranate supplements.

            1. BTW, the pomegranate juice did seem to have SOME benefits. From the study you pointed out:

              In exploratory analyses, in subjects in the most adverse tertiles for baseline serum lipid peroxides, triglycerides (TGs), high-density lipoprotein (HDL) cholesterol, TGs/HDL cholesterol, total cholesterol/HDL cholesterol, and apolipoprotein-B100, those in the pomegranate juice group had significantly less anterior wall and/or composite CIMT progression versus control subjects. In conclusion, these results suggest that in subjects at moderate coronary heart disease risk, pomegranate juice consumption had no significant effect on overall CIMT progression rate but may have slowed CIMT progression in subjects with increased oxidative stress and disturbances in the TG-rich lipoprotein/HDL axis.

              1. Yes but the “may have slowed CIMT progression in subjects with increased oxidative stress and disturbances in the TG-rich lipoprotein/HDL axis.” statement is a pretty slender thread on which to hang a claim that daily PJ consumption is beneficial for cardiovascular health.

          2. Thanks for pointing out the potential for bias in the study. I would assume that if the studies were randomized and blind, that would have been made quite obvious, and not testing it against a placebo is particularly odd. I appreciate the information.

  3. We analysed the dried pomegranate seeds from our Verganza plantation in Uzbekistan and it showed a phenominaly high ORAC value and well as a Vit B12 content (microbial?)

    Description: Organic dried pomegranate arils purple Varganza, Uzbekistan, chunk
    Results:
    Analysis Result Units
    ORAC against peroxyl radicals 63 µmole TE/gram
    ORAC against hydroxyl radicals 242 µmole TE/gram
    ORAC against peroxynitrite 18 µmole TE/gram
    ORAC against super oxide anion 232 µmole TE/gram
    ORAC against singlet oxygen 292 µmole TE/gram
    ORAC against hypochlorite 354 µmole TE/gram
    ORAC 6.0 (sum of above) 1,201 µmole TE/gram

    Powerful fruit I think. We also make whole fruit powder and juice powder from these little beauties.

  4. Why not make a cocktail of your favorite fruits by buying them in powdered form and mixing them? Ever so much easier than keeping fresh fruit, and easier to consume regularly too.

    For an extra kick, mix it in kombucha. (Homegrown costs pennies per quart.)

    Almost any fruit or berry powder can be had for $15 – $25 PER POUND!

    1. “Ever so much easier than keeping fresh fruit, and easier to consume regularly too.”
      – – – – – –

      And take away one of our (my) pleasures in life? I love ALL the fresh fruits when they’re in season. (I’ve never had the desire to taste pomegranate though.)

    2. But do they work the same?

      I ask that as a genuine question.

      I am actually eating the fruit and vegetables as meals, so I don’t want to just eat powder or drink it, but beet powder is the exception.

      I would like to do powdered beet juice, but dried fruits and vegetables didn’t retain the phytonutrients, or I think it was phytonutrients. We just had that video recently and dried didn’t make the cut for some things and I prefer my kale and beets as chips, so that sucked when I saw it.

      I have been eating Beet chips and Kale chips but switched back to regular Kale and no beets. I am not overly excited about regular Kale. It needs sprinkles of spices, I think. But I can eat regular Kale better than I can eat a can of beets every day and much, much better than I can do beet prep every day.

      I am pondering whether “powder” still means “dried” and it seems so likely that it does, but in the synergy study, they still did get excellent results with a powdered superfood mix, so a hit in the phytonutrients might still do something, if even placebo effect, though I am fascinated that the placebo effect worked better without the real food than with it (assuming both are placebo effects)

      I will have to think about how that happened.

      I would have understood a “statistically insignificant result” versus what happened.

      I am wondering if they used Stevia or something which may have a positive effect?

      1. I, personally, don’t like processed powders. The whole food has nutrients likely destroyed by processing.
        For people with gallbladder problems, for example, fresh, steamed or boiled beets are very helpful. But even the canned ones do not work at all!
        Powders are not whole foods. Besides that, eating whole foods replaces worse choices.

      2. Deb, you can boil several beets, and keep in frig, can be eaten hot or cold.
        I usually go grocery shopping on Friday night. Saturday morning I wash and prep everything for the week.
        Steam veggies while washing others. Makes weekday mealtimes so easy. Salads, stir-fries, soups are quick and easy for nights when I’m hungry and tired.

      3. Deb,
        After my bowl of fresh fruit every morning, I make a smoothie with: fresh beets (cut up), a few baby carrots, kale or arugula, ground flax seed, pumpkin seeds (shelled), tomatoes, two tablespoons ACV, add some filtered water and blend it which makes fresh vegetable juice w/o added salt. Sometimes I’ll add a 1/2 cup of frozen blueberries. This is a great way to eat your beets!

      4. There is a significant difference between (whole) fruit powder and fruit juice powder.

        I do take amla (powdered Indian gooseberry) on a regular basis and that seems to be beneficial.

    3. “Almost any fruit or berry powder can be had for $15 – $25 PER POUND!”

      Dear Navy Corpsman,

      With all due respect, I was under the impression that Dr. Greger’s diet is NOT called/about…a ‘Processed Foods Plant-Based Diet’,

      but a ‘Whole Foods Plant-Based Diet’.

      Too many people seem to be confused about this issue.

  5. I seem to recall consumers studies that brought into question how much pomegranate is in pomegranate juice. A previous comment mentioned a study that used whole food pomegranates along with other “super foods”. If we could trust the contents of foods, supplements and vitamins, we would benefit more from these substances.

  6. Thank you for this excellent topic! I value & refer to your work often in my medical (Neuro) practice
    David Kaminskas MD. Kailua Hawaii

    1. All dried fruits are too sweet for me. I can tolerate only what amounts to 1/4 teaspoon added to my morning gruel as it cooks.

      To think I used to like sugary foods way, way back in the day. Yuck. :-P

  7. It seems to me none of you are eating the seeds of the pomegranate.
    Just eating the flesh puts the sugar value up and changes the taste of the whole ariel.

    I’ve eaten pomegranates for years with the seeds. Pomegranate juice tastes nothing like the entire ariel. I don’t know of any studies done on the seeds but I’d say, that is where at least half of the benefits are.

    The juice without the seed is pointless as far as I’m concerned and that may be why the disappointing results. They are not meant to be consumed the way you people are consuming them.

    1. Who “you people”? Personally, I’ve never had a desire to even check ’em out, the juice or otherwise. There are too many other delicious fruits in the world.

      1. Did you think I was going to go through all the posters and list them by name one by one?

        You are probably too old and crotchety to be trying to eat pomegranates now anyway. You need to start before the age of 5 for the perfect addiction to this fruit. They are supremely messy to eat and the stains don’t come out.

        Of all the types of fruit there are, pomegranates are probably the most fun and interesting to eat. Each ariel is a ruby. A jewel packed with flavour and nutrition. They feel nice in your fingers. When loading them into your mouth, you wait until you have at least 5 ariels before you bite down. While you wait, your stimulated saliva pours into your mouth.

        As you bite down, the ariels explode into an unforgettable taste sensation each and every time. Your saliva pumps like it doesn’t with any other food.

        They are juicy and delicious but sort of tart at the same time.

        They take a long time to eat as well so they’re great to eat when you have a lot of time and nothing better to do with it.

        Not every pomegranate is a good one. Here in Canada many are damaged in transit and are brown and slimy inside. Or partly so. The ones shown in the blog’s photo are perfect. You don’t want them to look dried out.

        One thing they’re really good for is constipation. You wouldn’t know about that. Of course if the seeds aren’t eaten, then the taste is going to be all you care about. But drinking pomegranate juice out of a bottle is like wearing your winter coat back to front at the beach. The taste by itself from the bottle does not taste like pomegranate to me. Somehow it’s less.

  8. “While you wait, your stimulated saliva pours into your mouth.”
    – – – – –

    You gave the little critters some good press, but the thought of eating them still doesn’t get my juices going. (I’m a fussy bitch.)

    For me, there’s nothing like a ripe juicy Bartlett pear, or a sweet peach, or — yumies for the tummy — watermelon! Along with in-season cherries, yada yada yada.

    1. I enjoy all the fruit you do but you’ve limited yourself to an extremely narrow selection. You are the man who has 20/20 vision and doesn’t believe in telescopes or microscopes.
      Then claims he’s seen everything that matters.

      1. “….but you’ve limited yourself to an extremely narrow selection.”
        – – – – –

        “Extremely”? Just because I didn’t itemize every bloody one of them? Okay, let’s add blueberries, pineapples, oranges, grapefruits, apples, bananas, grapes…..

        I’ve never tasted a guava or a durian before either (as seen on the following list): https://www.healthline.com/nutrition/20-healthiest-fruits

        But I don’t mind that there are lots of things I’ll never do before I kick the bucket this time around. And that’s okay.

          1. The “yada yada yada” represented the rest of the bunch. I could have written “etc.” instead. I assumed you’d be able to imagine the others I had in mind.

            Whatever…..it’s all good. :-)

  9. Thank you for this article!!!! I had been hearing that both pomegranates and cranberries had some substances that fed specific good bacteria that was directly related to cancer prevention and or treatment for certain cancers.
    Interesting about the power of the placebo! Keep all the great analysis coming! Love it!

  10. Good evening,

    Thank you for taking the time to read my message.

    I am a 43-year-old female living near Atlanta, GA. One year ago, I was diagnosed with 3 blood clots in the Saphenous vein in the lower left leg. I have had 3 subsequent P.E’s in the lower lobes of both lungs. I was also diagnosed with the prothrombin g20210a gene. I was prescribed Xarelto 20mg 1x per day. Over the course of the past year, I have visited several different specialists for different conditions resulting from taking this medicine. Ultimately, I have undergone several procedures, and my vein specialist is recommending another. All of my doctors have agreed that I will be on Xarelto for life. This is not an answer I am willing to accept without exhausting all other avenues.

    I transitioned to a vegetarian diet in January 2017. I became completely vegan in February 2019. My work is very physically demanding. I am 205 lbs. All of my other numbers especially blood pressure, cholesterol are perfect.

    My question is: I am 43 – What can I do to get off of this RX safely? Is there a natural plant-based holistic way for my body to keep my blood from forming these detrimental clots, or am I on this RX for life?

    Kindest Regards,
    ~Kimber

  11. I am sorry to read of your medical challenges with clotting, and appreciate that you are attempting to eat well (hopefully WHOLE plant based foods) It’s understandable that with your history of recurring clots your doctors would focus on anticoagulant meds, yet I can understand with your experience having significant side effects why you would like a different approach. That may not be possible and certainly this website cannot make medical recommendations. However, you might want to schedule a personal medical consultation via phone, Skype, or FaceTime with a plant-based physcian who can review your complex medical history.
    Dr. Greger recommends his colleague Michael Klaper, M.D., who can be reached via his website http://doctorklaper.com/contact/
    To find a nutrition oriented clinician locally, we recommend looking on these sites:
    • Plant-based Docs – Find a Practitioner http://plantbaseddocs.com/listings/
    • American College of Lifestyle Medicine – Find a Lifestyle Medicine Practitioner http://lifestylemedicine.org/Find-a-Lifestyle-Medicine- Practitioner/
    • Dr. Mcdougall – Find a Health Care Practitioner https://www.drmcdougall.com/doctors/is
    I hope you can find a medical approach that will allow you to continue your active lifestyle with minimal medication side effects.

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