Friday Favorites: Benefits of Garlic Powder for Heart Disease

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In ancient Greece, the art of medicine was divided into three areas: cures through diet, cures through drugs, and cures through surgery. Garlic, Hippocrates wrote, was one such medicinal food, but that was to treat a nonexistent entity called “displacement of the womb.” So, ancient wisdom can only go so far.

Those who eat more than a clove a day do seem to have better artery function than those who eat less than a clove a day, but you don’t know if it’s cause and effect until you put it to the test.

Heart disease patients were randomized to receive either garlic powder or placebo tablets twice daily for three months. And, those lucky enough to be in the garlic group got a significant boost in their artery function: a 50 percent increase in function taking only 800 mg of garlic powder a day. That’s just a quarter-teaspoon of garlic powder; a 50 percent increase in artery function for less than a penny a day.

If regular, plain, boring garlic powder can do that, what about those fancy Kyolic aged garlic extract supplements? Thirty times more expensive, and they don’t work at all! Four weeks and zero significant improvement. It’s hard to improve on Mother Nature.

Garlic powder can improve the function of our arteries, but what about the structure of our arteries? Dozens of studies on garlic, all compiled together, show garlic can reduce cholesterol levels in the blood by more than 16 points. So, might garlic powder be able to actually slow the progression of atherosclerosis? Garlic powder tablet versus placebo for three months. The placebo group got worse, which is what tends to happen. Eat the same artery-clogging diet, and your arteries continue to clog. But, the progression of the disease appeared to slow and stall in the garlic group. Of course, it would be nice to see the artery wall thickening actually reverse, but for that, one might have to add more plants than just garlic to one’s diet. Still, though, that same quarter-teaspoon of a simple spice available everywhere may be considered as an adjunct treatment for atherosclerosis, the number one killer of both men and women in the United States and around much of the world.

What about garlic for high blood pressure? A systematic review and meta-analysis of randomized controlled trials demonstrating garlic has “a statistically significant and clinically meaningful effect” on both systolic and diastolic blood pressure, reducing the top number by nearly seven and the bottom number by about five. That may not sound like a lot, but reducing diastolic blood pressure—the bottom number—by five points can reduce the risk of stroke by about a third, and heart disease by 25 percent.

Plant-based medicine can provide beneficial effects, with little or no side effects, and “compared to other medicine are relatively cost effective.” I’d say so, at as little as a penny per day.

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• Totelin L. When foods become remedies in ancient Greece: The curious case of garlic and other substances. J Ethnopharmacol. 2015;167:30-7.
• Lau KK, Chan YH, Wong YK, et al. Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke. J Nutr Health Aging. 2013;17(7):600-4.
• Mahdavi-roshan M, Mirmiran P, Arjmand M, Nasrollahzadeh J. Effects of garlic on brachial endothelial function and capacity of plasma to mediate cholesterol efflux in patients with coronary artery disease. Anatol J Cardiol. 2017;18(2):116-121.
• Atkin M, Laight D, Cummings MH. The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial. J Diabetes Complicat. 2016;30(4):723-7.
• Shabani E, Sayemiri K, Mohammadpour M. The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis. Prim Care Diabetes. 2019;13(1):28-42.
• Mahdavi-roshan M, Zahedmehr A, Mohammad-zadeh A, et al. Effect of garlic powder tablet on carotid intima-media thickness in patients with coronary artery disease: a preliminary randomized controlled trial. Nutr Health. 2013;22(2):143-55.
• Xiong XJ, Wang PQ, Li SJ, Li XK, Zhang YQ, Wang J. Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials. Phytomedicine. 2015;22(3):352-61.
• Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665.

Image credit: John Phelan via wikimedia. Image has been modified.

Motion graphics by Avocado Video