Side Effects of Metformin as a Life-Extension Drug
As a mild mitochondrial poison, metformin carries a variety of downsides.
Topic summary contributed by volunteer(s): Randy
Kidney disease ranks as the ninth leading cause of death in the U.S. What may be some foods to avoid in order to keep our kidneys healthy? Due to toxic metal contamination, NeuG5c, alpha-gal, and advanced glycation end products (AGEs), meat (including poultry and processed meat), sugar, and high-fat meals should be avoided to maintain kidney health. Similarly, intake of betel nuts or star fruit can potentially shut down the kidneys, and the safety of chamomile tea for those with kidney disease has not yet been established. High-temperature cooking may create kidney cancer causing carcinogens.
Staying well hydrated, consuming phytates, which are in beans, nuts, seeds, and grains, and plant-based diets in general may help reduce kidney stone risk. Those with certain kidney stones should be cautious about nutritional yeast, turmeric, and beets. To eliminate uric acid kidney stones, drinking at least ten cups of water per day and reducing animal protein and salt intake may do the trick.
Overall, plant-based diets appear to boost kidney health. Plant-based, fiber-rich diets may protect against kidney and other cancers, reduce the risk of childhood prediabetes (which can lead to kidney damage) and diabetes, the top cause of kidney failure. No surprise, then, that plant-based diets can be used to both help prevent and treat kidney failure.
For substantiation of any statements of fact from the peer-reviewed medical literature, please see the associated videos below.
As a mild mitochondrial poison, metformin carries a variety of downsides.
Eating licorice or drinking licorice tea can cause the loss of body fat by blocking the effects of a stress hormone, but at what cost?
A misinterpretation of lab tests may explain concerns over kidney safety with creatine supplementation.
What are the three reasons plant protein is preferable to animal protein for kidney protection?
I share a touching story of the power of plant-based eating for chronic kidney failure.
How might we cut the risk of dialysis and death in half?
Healthy kidneys are required for potassium excretion. If you aren’t sure if you’re at risk, ask your doctor about getting your kidney function tested.
If the microbiome of those eating plant-based diets protects against the toxic effects of TMAO, what about swapping gut flora?
Various fasting regimens have been attempted for inflammatory autoimmune diseases such as lupus, ankylosing spondylitis, chronic urticaria, mixed connective-tissue disease, glomerulonephritis, and multiple sclerosis, as well as osteoarthritis and fibromyalgia.
For prevention and treatment of vitamin B12 deficiency, cyanocobalamin in chewable, sublingual, or liquid forms (rather than in a multivitamin) is best under most circumstances.
Green smoothies are put to the test for the autoimmune disease SLE (lupus).
DNA damage is assessed in users of aluminum cookware.
Star fruit contains a neurotoxin known as caramboxin that can cause irreversible brain damage at high enough doses.
Given their oxalate content, how much is too much spinach, chard, beet greens, chaga mushroom powder, almonds, cashews, star fruit, and instant tea?
Even though dietary oxalates may have a limited effect on kidney stone risk in most people, there are some predisposing factors that can put anyone at risk.
There have been at least eight randomized, double-blind, placebo-controlled trials of ginger for pain.
Chicken, fish, and egg powder in processed foods present greater risk from cholesterol oxidation byproducts, but there are things you can do to reduce exposure.
One way a diet rich in animal-sourced foods like meat, eggs, and cheese may contribute to heart disease, stroke, kidney failure, and death is through the production of toxin called TMAO.
Much of the lead found in adults today was deposited into our skeletons decades ago and is just now leaching out from our bones into our blood. What are the health consequences of having lead levels down around the American average?
Using skin lotion or hand sanitizer before touching thermal paper, such as cash register receipts and printed tickets, can facilitate the absorption of BPA into the body.
What are the three significant dietary risk factors for declining kidney function?
In this “best-of” compilation of his last four year-in-review presentations, Dr. Greger explains what we can do about the #1 cause of death and disability: our diet.
Anti-inflammatory drugs abolish the hyperfiltration and protein leakage response to meat ingestion, suggesting that animal protein causes kidney stress through an inflammatory mechanism.
Pilot studies on treating allergic eczema and severe asthma with dietary interventions have shown remarkable results.
An editorial by the Director of Yale’s Prevention Research Center on putting a face on the tragedy of millions suffering and dying from chronic diseases that could be prevented, treated, and reversed if doctors inspired lifestyle changes in their patients.
Just because something is natural and plant-based doesn’t mean it’s necessarily safe. Those who are pregnant, have gallstones, or are susceptible to kidney stones may want to moderate their turmeric consumption.
The cardiovascular benefits of plant-based diets may be severely undermined by vitamin B12 deficiency.
Even just a single egg a week may increase the risk of diabetes—the leading cause of lower-limb amputations, kidney failure, and new cases of blindness.
The consumption of phosphorus preservatives in junk food, and injected into meat, may damage blood vessels, accelerate the aging process, and contribute to osteoporosis.
One reason why soy consumption is associated with improved survival and lower recurrence rates in breast cancer patients may be because soy phytonutrients appear to improve the expression of tumor-suppressing BRCA genes.
Plant-based diets tend to be alkaline-forming. This may help protect muscle mass, and reduce the risk of gout and kidney stones. The pH of one’s urine can be estimated with natural pigments, using kitchen chemistry.
The decades-old dogma that the acid-forming quality of animal protein leads to bone loss has been called into question.
Most children don’t drink water from when they wake up to when they go off to school. Interventional trials show this mild state of dehydration may negatively affect scholastic performance.
The foreign meat molecule Neu5Gc may not only contribute to the progression of cancer and heart disease by supplying inflammation, but may also set children up for life-threatening reactions to E. coli toxins originating in the same animal products.
Death in America is largely a foodborne illness. Focusing on studies published just over the last year in peer-reviewed scientific medical journals, Dr. Greger offers practical advice on how best to feed ourselves and our families to prevent, treat, and even reverse many of the top 15 killers in the United States.
Not only do plant-based diets appear to prevent kidney function decline, they may also be used to treat kidney failure. Even at the same protein loads, the body is able to better handle phosphorus excretion from plant-based diets, reducing the risk of metastatic calcification.
Given how vascular our kidneys are, it should comes as no surprise that animal protein, animal fat, and cholesterol are associated with declining kidney function (microalbuminurea—loss of protein in the urine), which can be an early warning sign not only for kidney failure, but also for heart disease and a shortened lifespan.