Can small daily doses of herbs and spices really drop LDL cholesterol by double digits?
How to Lower Cholesterol with Herbs and Spices
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
In our last video, I talked about modifying the Daily Dozen to make it as cholesterol-lowering as possible. How might we tweak the spices entry? It already starts with a quarter teaspoon of turmeric.
Amla, dried Indian gooseberry, may decrease LDL cholesterol by 25 points in 12 weeks. Now, this was using an amla extract, which might equal about a half teaspoon of amla powder a day. Straight amla powder has also been tried. A third of a teaspoon a day may decrease LDL as much as 30 points or more, in both people with diabetes and without. So, let’s add amla to the list.
The spice sumac is another powdered berry. One or two grams a day can lower LDL by around nine points. The smallest effective dose would be about a half teaspoon a day, which is enough to significantly boost the efficacy of a statin drug by 11 points. Note that sumac is in the cashew and mango family; so, if you have an allergy to those, you may be allergic to sumac. But if not, you can add that too.
Dozens of randomized controlled trials involving thousands of participants, found significant cholesterol benefits with nigella seeds, also known as black cumin seeds, with whole powdered seeds more effective than just extracted black seed oil, and one study suggesting that whole unground seeds are also better than the powder. The smallest effective dose is 500 mg, which is only about a quarter teaspoon a day of unground seeds, or just a pinch of ground black cumin, about a tenth of a teaspoon.
Garlic powder can work at an even smaller dose, just 300 mg, which comes out to be about a tenth of a teaspoon of garlic powder, or a quarter of a clove of fresh garlic.
Powdered fenugreek can be considered a cholesterol-lowering medicinal plant, but the doses researchers used were huge. The lowest effective dose I could find of the whole spice used five grams four times a day, which is like five teaspoons of fenugreek powder—way more than culinary doses, which makes me concerned about long-term safety. The reason I mention this is because the benefit was extraordinary, a drop in LDL of more than 100 points compared to control. I don’t think I’ve ever seen a food do anything like that—reducing LDL by more than 50%. Hopefully, we’ll see future studies with more moderate doses.
The herb lemon balm can lower LDL at a dose of three grams a day, dropping LDL by 13 points over placebo. However, just drinking lemon balm tea does not appear to help. Also, possibly unsafe during pregnancy; but otherwise, a teaspoon a day may help. This is getting to be quite a list!
The herb savory, also known as summer savory, may be even more potent, with a third of a teaspoon reducing LDL by as much as 27 points over placebo. So, let’s definitely add that as well!
Obviously, you can just pick and choose whichever you enjoy, but if the goal is to get our LDL as low as possible using every possible safe, simple solution, how might we easily, conveniently get as many of these as possible? That’s exactly what Dr. Greger will cover in the final video of this series, next.
Please consider volunteering to help out on the site.
- Acampado LRT, Chiu HHC, Larrazabal RB, Arcellana AES, Añonuevo-Cruz MCS. The efficacy and safety of emblica officinalis aqueous fruit extract among adult patients with dyslipidemia: a systematic review and meta-analysis. Acta Med Philipp. 2023;57(5):90-95.
- Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-616.
- Bahari H, Taheri S, Namkhah Z, Barghchi H, Arzhang P, Nattagh-Eshtivani E. Effects of sumac supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2024;38(1):241-252.
- Rouhi-Boroujeni, Mosharraf S, Gharipour M, Asadi-Samani M, Rouhi-Boroujeni H. Anti-hyperelipidemic effects of Sumac (Rhus coriaria L.): Can sumac strengthen anti-hyperlipidemic effect of statins?. Pharm Lett. 2016;8(3):143-147.
- Bastiaan-Net S, Reitsma M, Cordewener JHG, et al. Ige cross-reactivity of cashew nut allergens. Int Arch Allergy Immunol. 2019;178(1):19-32.
- Shabani M, Ghavidel F, Rajabian A, et al. Effect of nigella sativa consumption on lipid profile and glycemic index in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2014;61:168-180.
- Alamri E. Comparison of the effect of nigella sativa seeds and powder on lipid profile in Saudi Arabian adults. Proc Nutr Soc. 2019;78(OCE1):E12.
- Kwak JS, Kim JY, Paek JE, et al. Garlic powder intake and cardiovascular risk factors: a meta-analysis of randomized controlled clinical trials. Nutr Res Pract. 2014;8(6):644-654.
- Heshmat-Ghahdarijani K, Mashayekhiasl N, Amerizadeh A, Teimouri Jervekani Z, Sadeghi M. Effect of fenugreek consumption on serum lipid profile: A systematic review and meta-analysis. Phytother Res. 2020;34(9):2230-2245.
- Kumar K, Kumar S, Datta A, Bandyopadhyay A. Effect of fenugreek seeds on glycemia and dyslipidemia in patients with type 2 diabetes mellitus. Int J Med Sci Public Health. 2015;4(7):997-1000.
- Shahsavari K, Shams Ardekani MR, Khanavi M, Jamialahmadi T, Iranshahi M, Hasanpour M. Effects of Melissa officinalis (Lemon balm) consumption on serum lipid profile: a meta-analysis of randomized controlled trials. BMC Complement Med Ther. 2024;24(1):146.
- Jandaghi P, Noroozi M, Ardalani H, Alipour M. Lemon balm: A promising herbal therapy for patients with borderline hyperlipidemia-A randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2016;26:136-140.
- Kheirkhah J, Ghorbani Z, Salari A, et al. Melissa officinalis tea favourably affects the frequency of premature ventricular beats and cardiometabolic profile among patients with premature ventricular contraction: A randomised open-label controlled trial. Int J Clin Pract. 2021;75(10):e14644.
- Ulbricht C, Brendler T, Gruenwald J, et al. Lemon balm (Melissa officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother. 2005;5(4):71-114.
- Nikaein F, Babajafari S, Mazloomi SM, Zibaeenezhad M, Zargaran A. The effects of satureja hortensis l. Dried leaves on serum sugar, lipid profiles, hs-CRP, and blood pressure in metabolic syndrome patients: a double-blind randomized clinical trial. Iran Red Crescent Med J. 2016;19(1):e34931.
Motion graphics by Avo Media
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
In our last video, I talked about modifying the Daily Dozen to make it as cholesterol-lowering as possible. How might we tweak the spices entry? It already starts with a quarter teaspoon of turmeric.
Amla, dried Indian gooseberry, may decrease LDL cholesterol by 25 points in 12 weeks. Now, this was using an amla extract, which might equal about a half teaspoon of amla powder a day. Straight amla powder has also been tried. A third of a teaspoon a day may decrease LDL as much as 30 points or more, in both people with diabetes and without. So, let’s add amla to the list.
The spice sumac is another powdered berry. One or two grams a day can lower LDL by around nine points. The smallest effective dose would be about a half teaspoon a day, which is enough to significantly boost the efficacy of a statin drug by 11 points. Note that sumac is in the cashew and mango family; so, if you have an allergy to those, you may be allergic to sumac. But if not, you can add that too.
Dozens of randomized controlled trials involving thousands of participants, found significant cholesterol benefits with nigella seeds, also known as black cumin seeds, with whole powdered seeds more effective than just extracted black seed oil, and one study suggesting that whole unground seeds are also better than the powder. The smallest effective dose is 500 mg, which is only about a quarter teaspoon a day of unground seeds, or just a pinch of ground black cumin, about a tenth of a teaspoon.
Garlic powder can work at an even smaller dose, just 300 mg, which comes out to be about a tenth of a teaspoon of garlic powder, or a quarter of a clove of fresh garlic.
Powdered fenugreek can be considered a cholesterol-lowering medicinal plant, but the doses researchers used were huge. The lowest effective dose I could find of the whole spice used five grams four times a day, which is like five teaspoons of fenugreek powder—way more than culinary doses, which makes me concerned about long-term safety. The reason I mention this is because the benefit was extraordinary, a drop in LDL of more than 100 points compared to control. I don’t think I’ve ever seen a food do anything like that—reducing LDL by more than 50%. Hopefully, we’ll see future studies with more moderate doses.
The herb lemon balm can lower LDL at a dose of three grams a day, dropping LDL by 13 points over placebo. However, just drinking lemon balm tea does not appear to help. Also, possibly unsafe during pregnancy; but otherwise, a teaspoon a day may help. This is getting to be quite a list!
The herb savory, also known as summer savory, may be even more potent, with a third of a teaspoon reducing LDL by as much as 27 points over placebo. So, let’s definitely add that as well!
Obviously, you can just pick and choose whichever you enjoy, but if the goal is to get our LDL as low as possible using every possible safe, simple solution, how might we easily, conveniently get as many of these as possible? That’s exactly what Dr. Greger will cover in the final video of this series, next.
Please consider volunteering to help out on the site.
- Acampado LRT, Chiu HHC, Larrazabal RB, Arcellana AES, Añonuevo-Cruz MCS. The efficacy and safety of emblica officinalis aqueous fruit extract among adult patients with dyslipidemia: a systematic review and meta-analysis. Acta Med Philipp. 2023;57(5):90-95.
- Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-616.
- Bahari H, Taheri S, Namkhah Z, Barghchi H, Arzhang P, Nattagh-Eshtivani E. Effects of sumac supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2024;38(1):241-252.
- Rouhi-Boroujeni, Mosharraf S, Gharipour M, Asadi-Samani M, Rouhi-Boroujeni H. Anti-hyperelipidemic effects of Sumac (Rhus coriaria L.): Can sumac strengthen anti-hyperlipidemic effect of statins?. Pharm Lett. 2016;8(3):143-147.
- Bastiaan-Net S, Reitsma M, Cordewener JHG, et al. Ige cross-reactivity of cashew nut allergens. Int Arch Allergy Immunol. 2019;178(1):19-32.
- Shabani M, Ghavidel F, Rajabian A, et al. Effect of nigella sativa consumption on lipid profile and glycemic index in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2014;61:168-180.
- Alamri E. Comparison of the effect of nigella sativa seeds and powder on lipid profile in Saudi Arabian adults. Proc Nutr Soc. 2019;78(OCE1):E12.
- Kwak JS, Kim JY, Paek JE, et al. Garlic powder intake and cardiovascular risk factors: a meta-analysis of randomized controlled clinical trials. Nutr Res Pract. 2014;8(6):644-654.
- Heshmat-Ghahdarijani K, Mashayekhiasl N, Amerizadeh A, Teimouri Jervekani Z, Sadeghi M. Effect of fenugreek consumption on serum lipid profile: A systematic review and meta-analysis. Phytother Res. 2020;34(9):2230-2245.
- Kumar K, Kumar S, Datta A, Bandyopadhyay A. Effect of fenugreek seeds on glycemia and dyslipidemia in patients with type 2 diabetes mellitus. Int J Med Sci Public Health. 2015;4(7):997-1000.
- Shahsavari K, Shams Ardekani MR, Khanavi M, Jamialahmadi T, Iranshahi M, Hasanpour M. Effects of Melissa officinalis (Lemon balm) consumption on serum lipid profile: a meta-analysis of randomized controlled trials. BMC Complement Med Ther. 2024;24(1):146.
- Jandaghi P, Noroozi M, Ardalani H, Alipour M. Lemon balm: A promising herbal therapy for patients with borderline hyperlipidemia-A randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2016;26:136-140.
- Kheirkhah J, Ghorbani Z, Salari A, et al. Melissa officinalis tea favourably affects the frequency of premature ventricular beats and cardiometabolic profile among patients with premature ventricular contraction: A randomised open-label controlled trial. Int J Clin Pract. 2021;75(10):e14644.
- Ulbricht C, Brendler T, Gruenwald J, et al. Lemon balm (Melissa officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother. 2005;5(4):71-114.
- Nikaein F, Babajafari S, Mazloomi SM, Zibaeenezhad M, Zargaran A. The effects of satureja hortensis l. Dried leaves on serum sugar, lipid profiles, hs-CRP, and blood pressure in metabolic syndrome patients: a double-blind randomized clinical trial. Iran Red Crescent Med J. 2016;19(1):e34931.
Motion graphics by Avo Media
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How to Lower Cholesterol with Herbs and Spices
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Content URLDoctor's Note
This is the 15th video in an extended series on the critically important topic of how to lower LDL cholesterol, the primary driver of our primary killer. In this series, we take a deep dive into ways we may lower our cholesterol through diet. We’ll explore the Portfolio Diet, plant sterols, and cholesterol-lowering supplements, foods, herbs, and spices, before concluding with my Portfolio Plus Powder recipe “cooking” video.
If you don’t want to wait for all the videos to be released, we’ve compiled all the information into our latest book, Lower LDL Cholesterol Naturally with Food, available as a softcover, ebook, and audiobook.
If you missed the previous videos in this series, see:
- Why Isn’t Everyone on Cholesterol-Lowering Statin Drugs?
- How Effective Are Statins?
- The Side Effects of Statins: Are They Worth It?
- What Is the Best Statin Cholesterol-Lowering Drug?
- How to Lower Cholesterol with the Portfolio Diet
- Are Plant Sterols Effective for Lowering Cholesterol?
- Are Plant Sterols Safe for Lowering Cholesterol?
- The Best Source and Dose of Plant Sterols for Lowering Cholesterol
- Why I Don’t Recommend Policosanol Cholesterol-Lowering Supplements
- Why I Don’t Recommend Red Yeast Rice Cholesterol-Lowering Supplements
- How to Lower Cholesterol with Supplements That Actually Work
- Barberries Rather Than Berberine to Lower Cholesterol
- Statin Drugs vs. Cholesterol-Lowering Dietary Supplements
- Foods That Lower Cholesterol
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