Doctor's Note

There’s also the issue of the goitrogenic compounds in raw cruciferous. See my video, Overdosing on Greens. We can also drink too much tea (see Overdosing on Tea); eat too much of the spice turmeric (see Oxalates in Cinnamon); too much of the seaweed kelp (see Too Much Iodine Can Be as Bad as Too Little); and overdo coffee when pregnant (see Caffeine During Pregnancy). 

For more context, check out my associated blog posts: The Best Detox, and Broccoli Boosts Liver Detox Enzymes.

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  • Michael Greger M.D.

    There is also the issue of the goitrogenic compounds in raw cruciferous. See my video Overdosing on Greens. We can also drink too much tea (see Overdosing on Tea), eat too much of the spice turmeric (see Oxalates in Cinnamon), too much of the seaweed kelp (see Too Much Iodine Can Be As Bad As Too Little), and overdo coffee when pregnant (see Caffeine During Pregnancy). And that’s just a smattering of the hundreds of other videos on more than a thousand subjects.

  • Matt

    Could this be vitamin A toxicity?

  • More is not always better. Some phytochemicals work (at normal consumption levels) by stressing our cells slightly, causing a protective response.

    There’s a whopper of a series of videos one could do on hormetic effects (low-dose good, high dose toxic) of phytonutrients. Many of the protective plants noted by Dr. Greger so far seem to activate the cellular Nrf2 signalling pathway, causing production of hundreds of protective and repair enzymes. Just from this somewhat dated but excellent review:

    sulforaphane (cruciferous vegetables like broccoli, cabbage, kale), curcumin (tumeric), EGCG (green but not black tea), diallyl sulfide, diallyl trisulfide, s-allylcysteine (garlic), resveratrol (grapes & wine), lycopene (tomatoes), capsaicin (hot pepper), piperine (black pepper), carnosol (rosemary), cinnamaldehyde (cinnamon), cafestol, kahweol (coffee), chalcone (citrus, apples, tomatoes, shallots, bean sprouts), xanthohumol (hops), eupatilin (terragon), isoorientin (acai), quercetin (red onions, watercress, kale, berries, sweet potatoes).

    all induce activation of the Nrf2 antioxidant response/repair axis, and are hence “sensed” by the cells as stressors. It may well be these phytochemicals’ stressor effect rather than their in vitro antioxidant capacity that accounts for their health benefits. A number of them (tumeric, tea catechins) are known to be hormetic: toxins at very large (concentrated supplement) doses.

    In line with a common refrain of Dr. Greger’s, its likely better to get them in food rather than pills – its one way to keep dosing in the hormetic range.

    There are presently 29,000 articles on referencing Nrf2, 16,000 in just the past five years. But while the subject is a very deep one, it also, brings a bit of simplicity and order to the question of why so many plant foods have protective and theraputic effects, at normal food doses.

  • Burt

    Hi .. I had to listen to this twice. It sounds like you’re saying there’s NOT a problem with drinking that much broccoli juice (2, 3 cups or so per day), correct? The video started out sounding like it could cause problems, then you refer to formal study, which said there weren’t any problems. Can you please clarify … Asking because I’m thinking about doing a regular broccoli juice routine. Thank you ..

    • Wegan

      The last part was talking about sprout extract. Eat it whole and you’ll be fine.

  • Juicy

    This video is mesleading and unclear.they make it sound dangerous at the first part then suddenly they will say its ok to drink brocoli juice even though u overdose..duh

  • Lisa Brown

    Should you cook broccoli sprouts to reduce toxicity? And add daikon, mustard or horseradish to water to boost its power? Also heard rinsing sprouts with a bit of sugar in the water boosts it too? Any truth to these statements?

  • Rob Di Censo

    I was wondering if there is any info on the benefits of Milk Thistle in terms of its ability to stimulate and protect the process of glutathione production. I started taking it for my condition (U. Colitis) and it seems to be helping quite a bit.

  • 4Baccurate

    Aside from the question of amount taken, the woman might have been hypersensitive to indole-3-carbinol.