Hormone Treatment (Estrogen Pills and Creams) for Vaginal Menopause Symptoms

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Does vaginal estrogen carry the same risk as oral estrogen?

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Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.

In my last video, I explained how the first-line treatment for mild to moderate vaginal dryness due to menopause are lubricants and moisturizers, and I called out the safest brands. If over-the-counter lubricants and moisturizers are insufficient to control the genitourinary symptoms of menopause, low-dose, local estrogen therapy is recommended, unless women have a history of hormone-dependent cancers like endometrial or breast. Local, meaning applied vaginally, as opposed to taken orally. Vaginal application is considered safer and more effective than systemic hormone therapy. A meta-analysis of 58 studies comparing vaginal to systemic estrogens found that vaginal estrogen therapy offered better symptom relief than estrogen pills, patches, or implants. In fact, many women who are on systemic menopausal hormone therapy have to add on supplemental vaginal estrogens to control symptoms.

Vaginal estrogens are available as a variety of creams, suppositories, and rings. Thirty randomized, control comparative trials have been performed, and there appears to be no difference in efficacy between the various preparations. However, they may take weeks before a noticeable alleviation of symptoms is detected, and two to three months before the full effect is achieved. Although year-long studies can clearly demonstrate vaginal estrogen’s benefit, studies as long as 12 weeks have failed to manifest superiority to placebo.

Some of the estrogen applied to the vulva or vagina is systemically absorbed, and therefore conveys the same black box FDA notice that oral estrogens carry, an all-caps warning of increased risk of “endometrial cancer, cardiovascular disorders, breast cancer and probable dementia.” Vaginal estrogen is considered safer, though, since it can be used at a much lower dose (as low as one-hundredth the oral dose). The Harvard Nurse’s Health Study did not find any increased risks associated with vaginal estrogen use over 18 years of follow-up. Randomized controlled trials lasting up to a year appear to confirm its safety, but there have been observational studies linking vaginal use to about a doubling of odds for endometrial cancer. But this was done back in the 1970s when higher estrogen doses were used. And a more recent study out of Denmark that found the same thing may have been confounded by concurrent oral estrogen exposure. Out of an abundance of caution, though, even low-dose localized estrogen may be contraindicated in hormone-dependent cancer survivors, to be on the safe side.

Breast cancer survivors suffering from GSM may want to consider vaginal DHEA instead. Oral DHEA doesn’t appear to offer any benefit, but in 2016 the FDA approved vaginal DHEA suppositories for pain during intercourse due to menopause. It’s converted locally into estrogen, and does not significantly affect systemic hormone levels. A downside is that it has to be administered nightly, whereas estrogen preparations are typically twice a week, or even every few months with the vaginal rings. For those who would rather an oral treatment, there’s ospemifene, a tamoxifen-type drug that has pro-estrogenic effects on the vaginal lining. However, it can actually double the rate of hot flashes and urinary tract infections in the short-term, and insufficient data is available for long-term safety.

Please consider volunteering to help out on the site.

Motion graphics by Avo Media

Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.

In my last video, I explained how the first-line treatment for mild to moderate vaginal dryness due to menopause are lubricants and moisturizers, and I called out the safest brands. If over-the-counter lubricants and moisturizers are insufficient to control the genitourinary symptoms of menopause, low-dose, local estrogen therapy is recommended, unless women have a history of hormone-dependent cancers like endometrial or breast. Local, meaning applied vaginally, as opposed to taken orally. Vaginal application is considered safer and more effective than systemic hormone therapy. A meta-analysis of 58 studies comparing vaginal to systemic estrogens found that vaginal estrogen therapy offered better symptom relief than estrogen pills, patches, or implants. In fact, many women who are on systemic menopausal hormone therapy have to add on supplemental vaginal estrogens to control symptoms.

Vaginal estrogens are available as a variety of creams, suppositories, and rings. Thirty randomized, control comparative trials have been performed, and there appears to be no difference in efficacy between the various preparations. However, they may take weeks before a noticeable alleviation of symptoms is detected, and two to three months before the full effect is achieved. Although year-long studies can clearly demonstrate vaginal estrogen’s benefit, studies as long as 12 weeks have failed to manifest superiority to placebo.

Some of the estrogen applied to the vulva or vagina is systemically absorbed, and therefore conveys the same black box FDA notice that oral estrogens carry, an all-caps warning of increased risk of “endometrial cancer, cardiovascular disorders, breast cancer and probable dementia.” Vaginal estrogen is considered safer, though, since it can be used at a much lower dose (as low as one-hundredth the oral dose). The Harvard Nurse’s Health Study did not find any increased risks associated with vaginal estrogen use over 18 years of follow-up. Randomized controlled trials lasting up to a year appear to confirm its safety, but there have been observational studies linking vaginal use to about a doubling of odds for endometrial cancer. But this was done back in the 1970s when higher estrogen doses were used. And a more recent study out of Denmark that found the same thing may have been confounded by concurrent oral estrogen exposure. Out of an abundance of caution, though, even low-dose localized estrogen may be contraindicated in hormone-dependent cancer survivors, to be on the safe side.

Breast cancer survivors suffering from GSM may want to consider vaginal DHEA instead. Oral DHEA doesn’t appear to offer any benefit, but in 2016 the FDA approved vaginal DHEA suppositories for pain during intercourse due to menopause. It’s converted locally into estrogen, and does not significantly affect systemic hormone levels. A downside is that it has to be administered nightly, whereas estrogen preparations are typically twice a week, or even every few months with the vaginal rings. For those who would rather an oral treatment, there’s ospemifene, a tamoxifen-type drug that has pro-estrogenic effects on the vaginal lining. However, it can actually double the rate of hot flashes and urinary tract infections in the short-term, and insufficient data is available for long-term safety.

Please consider volunteering to help out on the site.

Motion graphics by Avo Media

Doctor's Note

Cancers, clots, and dementia? For more on the risks of systemic hormone “replacement” therapy for menopause, see How Did Doctors Not Know About the Risks of Hormone Therapy?

This was the second video in a three-part series. If you missed the first one, see The Best Moisturizers and Lubricants for Vaginal Menopause Symptoms. 

Soy Milk for Vaginal Menopause Symptoms is next. 

What about hot flashes? See Menopausal Hot Flashes Are Not Inevitable and Soy Foods for Menopause Hot Flash Symptoms. 

You may also be interested in How to Delay the Age of Menopause with Diet and Lifestyle Factors.

For more on how to live your longest, healthiest life, preorder my new book How Not to Age. (As always, all proceeds I receive from all of my books are donated to charity.)

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