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Amyloid and Apple Juice

Ginger and apple juice appear to protect human nerve cells from the neurotoxic Alzheimer’s plaque protein amyloid Beta in a petri dish.

November 24, 2011 |
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Acknowledgements

Images thanks to the Alzheimer's Disease Education and Referral Center, a service of the National Institute on Aging, and Jensflorian via Wikimedia Commons, as well as iamnotanorange.

Transcript

The 6th leading cause of death in the United States continues to be Alzheimer’s disease, currently afflicting nearly 5 million Americans.

The disease process involves the buildup of a protein in the brain called amyloid beta, which is neurotoxic—it kills brain cells, leading to brain shrinkage, cognitive decline, and eventually death.

In May 1970… a 4-year-old girl we know only by her initials L. S. presented to Sloan-Kettering with a nerve tumor. They cut it out, radiation, chemo, nothing helped and she died months later. But her cancer lives on, still going 40 years later in laboratories around the world. An undying cell line of human nerve cells.

And that’s one way new Alzheimer’s treatments are tested. You take a petri dish of these nerve cells, expose them to the neurotoxic Alzheimer’s protein amyloid Beta, and they die. This is a measure of cell death. Then you do the same thing, but this time you add a substance X, whatever you’re testing, to see if it saves the nerve cells from death. First you just add a little, a 1 in 100 dilution, and if you’re lucky, less death. -ah hah. So you try a little more, a 1 in 50 dilution, and if you’re really lucky, whoa, you’re back to control. It’s like you never even added amyloid. Completely blocked the neurotoxicity of amyloid Beta. What is this substance X, what is this, “AJC”? Apple juice concentrate. Seriously, they just dripped some diluted apple juice on some nerve cells and, at least in a petri dish, it worked.

A similar finding was reported this year with ginger. The control cells have 100% viability, but half die when you add amyloid beta, but adding a little ginger, or a little more, improves nerve cell survival.

The question I had when I read this study, though, was why didn't they use the whole apple, blended up, instead of just using apple juice. As always, follow the money. He who pays the piper picks the tune; the study was funded by the Processed Apples Institute.

To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Peter Mellor.

To help out on the site please email volunteer@nutritionfacts.org

Dr. Michael Greger

Doctor's Note

Please feel free to post any ask-the-doctor type questions here in the comments section and I’d be happy to try to answer them. And be sure to check out all the videos on brain disease and industry influence.

For some context, please check out my associated blog posts: Alzheimer's Disease: Up to half of cases potentially preventableCountering Dietary Pollutants & Pesticides, and Dr. Greger's Natural Nausea Remedy Recipe

  • http://nutritionfacts.org/members/mgreger/ Michael Greger M.D.

    Please feel free to post any ask-the-doctor type questions here in the comments section and I’d be happy to try to answer them. And be sure to check out all the videos on brain disease and industry influence.

  • http://nutritionfacts.org/members/meha/ Meha

    Ok, this is the sixth. I want know all the top 10. Someone told me no tobacco, no alcohol, no animal products and regular workout is enough to avoid de top 10. Is that true?

    • http://nutritionfacts.org/members/mgreger/ Michael Greger M.D.

      If you click on the Sources Cited section under the video you can read the latest CDC report on top causes of death in the United States. The top 10 are 1) heart disease, 2) cancer, 3) COPD, 4) stroke, 5) accidents, 6) Alzheimer’s, 7) diabetes, 8) pneumonia, 9) kidney disease, and 10) suicide. So being a nonsmoker who exercises and eats a plant based diet would certainly dramatically reduce your risk of the majority of these, but you’d still be advised to wear your seat belt, bike helmet, check your smoke detector, etc. For more on maximising your longevity check out my 37 videos on mortality.

      • Dilshad

        I have a question about Amyliodosis. Isn’t Green Tea and some Herbs beneficial to halt the progression of Amyliod Proteins? Meditiation and Yoga can cure Amyliodosis, isn’t it so? If you do stomach exercise as Baba Ramdev says. I believe some effect could result…..

    • http://nutritionfacts.org/members/drdons/ DrDons

      Hi Meha, I wanted to add another list and a couple thoughts to Dr. Gregers excellent response. A 2002 report listed the following: 1)Heart Disease 2)cancer 3)Medical Care 4)Stroke 5)Chronic Respiratory Disease 6)Accidents7)Diabetes 8)Influenza&Pneumonia 9)Alzheimer’s 10)Fire Arms.. slightly different leads to similar recommendations. I would add maintaining a good body weight. It is possible to be a “fat” vegan as John McDougall points out in his December 2008 newsletter.Dr. Gregers videos on avoiding heart disease #1- http://nutritionfacts.org/videos/low-fat-or-whole-food/ and on avoiding cancer #2- http://nutritionfacts.org/videos/slowing-the-growth-of-cancer-3/ are especially pertinent.. it goes without saying if you make good behavioral choices you will avoid the third leading cause of death… the medical industry!

  • http://nutritionfacts.org/members/synergy/ Synergy

    Can the results be trusted given the fact that they were sponsored by an institute that is set to profit from the findings?

  • Michael Greger M.D.

    For some context, please check out my associated blog post Alzheimer’s Disease: Up to half of cases potentially preventable!

  • H

    What do you recommend for chronic depression pleas?