Saffron vs. Aricept

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The spice saffron was compared to donepezil (Aricept), a leading drug treatment for slowing the progression of Alzheimer’s disease cognitive impairment.

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Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.

The spice saffron beat out placebo in this randomized double-blind study. But Alzheimer’s patients aren’t on sugar pills; they’re on drugs like donepezil, sold as Aricept. If some drug company wanted to release a new drug, they’d have to compare it not to placebo, but to the current leading treatment—and why should it be any different with flowers? “A 22-week, multicenter, randomized, double-blind controlled trial of [saffron] in the treatment of mild-to-moderate Alzheimer’s disease.” Saffron versus Aricept, the leading drug.

Here are the results. In a graph of cognitive dysfunction, the circles are saffron. The triangles are the leading drug that costs about $2,000 a year, and is associated with all sorts of side effects. Can you tell the difference? Saffron worked just as well as Aricept—which is to say not very well at all.

But remember what untreated Alzheimer’s patients look like? They get worse. The reason drugs are prescribed is to just slow down the progression of Alzheimer’s. So, we still have a long way to go, but saffron appeared to work just as well as the leading drug, and without the side effects.

Please consider volunteering to help out on the site.

Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.

The spice saffron beat out placebo in this randomized double-blind study. But Alzheimer’s patients aren’t on sugar pills; they’re on drugs like donepezil, sold as Aricept. If some drug company wanted to release a new drug, they’d have to compare it not to placebo, but to the current leading treatment—and why should it be any different with flowers? “A 22-week, multicenter, randomized, double-blind controlled trial of [saffron] in the treatment of mild-to-moderate Alzheimer’s disease.” Saffron versus Aricept, the leading drug.

Here are the results. In a graph of cognitive dysfunction, the circles are saffron. The triangles are the leading drug that costs about $2,000 a year, and is associated with all sorts of side effects. Can you tell the difference? Saffron worked just as well as Aricept—which is to say not very well at all.

But remember what untreated Alzheimer’s patients look like? They get worse. The reason drugs are prescribed is to just slow down the progression of Alzheimer’s. So, we still have a long way to go, but saffron appeared to work just as well as the leading drug, and without the side effects.

Please consider volunteering to help out on the site.

Doctor's Note

For more on Alzheimer’s disease, check out these videos:
Reducing Glycotoxin Intake to Prevent Alzheimer’s
Preventing Alzheimer’s with Turmeric
Treating Alzheimer’s with Turmeric

Also see my prequel video: Saffron for the Treatment of Alzheimer’s.

2017 Update: Since this video was released, I’ve done several more on saffron. See: 

For additional context, also check out my associated blog posts: Natural Alzheimer’s Treatment; Alzheimer’s Disease: Up to half of cases potentially preventable; Saffron vs. Prozac for Depression; and Is Coconut Oil Bad For You?

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