Black raspberries may cause complete clinical regression of precancerous oral lesions (oral intraepithelial neoplasia).
More berried treasure: A story similar to the strawberries and esophageal cancer revelation has emerged with black raspberries and oral cancer. Again it started with in-vitro studies. Oral cancer is one of the 10 most common cancers in the US with a flip-of-the-coin death rate. We can reduce our risk of oral cancer by avoid all forms of tobacco, restricting alcohol consumption, avoiding obesity, and eating at least five servings of vegetables and fruits each day, as well as shooting for fewer than 6 lifetime oral sex partners and avoiding prolonged marijuana use—meaning more than about 20 years. But what if you already have precancerous changes in your mouth?
Well, black raspberries appear to selectively inhibit the growth of both malignant and premalignant cells, but not normal cells—just what we want, but that's just in a petri dish. So they took some folks with precancerous growth in their mouths, so called oral intraepithelial neoplasia, and had them rub a black raspberry gel on it for 6 weeks. Like the esophageal study with strawberries, most of the patients' lesions improved, including complete clinical regression. Now you see it; now you don't. Thanks to just berries. They were able to follow a reversal of genetic changes that had led to the silencing of tumor suppressor genes.
The gel was just to get the berries to stick to the lesions, so they didn't have to eat berries all day. Now they're getting even more high tech, developing Injectable Millicylindrical berry Implants. Unlike standard local delivery formulations, which require multiple, repeated dosing throughout the day, implantable vehicles alleviate concerns with multiple dosing schedules and poor patient compliance. They fill up these microscopic little barrels with black raspberry power, inject them into a lesion, and they slowly dissolve, releasing their phytonutrients over a whole month.
For those who'd rather eat their berries the old fashioned way, unfortunately you have to pretty much be in Oregon the three weeks in July when these particular berries are harvested to get your hands on them. I've never seen them frozen in stores. You can order them online, frozen but they're like 20 bucks a pound with shipping. The freeze-dried powder is comparatively cheaper, but I've always wondered about how much nutrition is lost. Well, there's finally been a study. The antioxidant concentration was measured in fresh, frozen, and freeze-dried strawberries and strawberry jam, with the intent of measuring antioxidant content of foods typically available to consumers in grocery stores.
On a gram for gram dry weight basis the freeze-drying holds up remarkably well, even better than freezing. Jam, though, presumably because of the heat processing, really takes a hit. On a consumed weight basis, though, the freeze-dried do shine, but just because an ounce of dried is equivalent to about a cup and a half of fresh.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Ariel Levitsky.
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What strawberries and esophageal cancer revelation you ask? That was in my last video Strawberries versus Esophageal Cancer, following up on Cranberries versus Cancer and Which Fruit Fights Cancer Better?
I've previously covered the clinical trials of black raspberries (though in a different orifice) in Best Fruits For Cancer Prevention. I also touched on the adverse effects of breathing smoke from any source in Cannabis Receptors & Food.
Berries in general are the healthiest fruits and I encourage everyone to try to fit them into their daily diet. Here are a few of my 37 other videos on berries:
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