The foreign meat molecule Neu5Gc builds up in human tumors and atherosclerotic plaques and may play an inflammatory role in the progression of both diseases.
The foreign meat molecule Neu5Gc tends to accumulate particularly in the lining of hollow organs (where carcinomas like breast cancer develop inside your glands) or in the lining blood of vessels (where atherosclerosis occurs).” “Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium.” The Neu5Gc accumulation may facilitate production of anti-Neu5Gc antibodies and further aggravate chronic inflammation in atherosclerosis progression in addition to just cancer. Here you can see it stained in red lining the aorta of a human autopsy sample, and here you can actually see it inside atherosclerotic plaques. Providing multiple pathways for accelerating inflammation in this disease. Remember we lost the ability to make this substance millions of years ago. Whether it’s feeding inflammation to our cancer or our heart disease, it all came from the animal products in our diet. “Taken together, these findings suggest a mechanism whereby anti-Neu5Gc antibodies can initiate, perpetuate, and/or exacerbate an inflammatory response at the endothelium, (the lining of our arteries) potentially playing a role in disease states such as atherosclerosis, wherein vascular inflammation is involved. Neu5Gc is a novel dietary and human- specific “xeno-auto-antigen” that may exacerbate a variety of vascular pathologies.” They go onto note that it we actually ate what the USDA recommends for protein in the form of meat and dairy, we could in to ingest as much 10 mg of Neu5Gc per day, which is 10mg more than we evolved to have in our bodies since as a species we stopped making it millions of years ago before we started eating meat. Novel therapeutic approaches to reducing or dampening flares of immunologic responses against the endothelium…could include reduction of dietary Neu5Gc intake and accumulation through simple diet-based interventions.” Not so novel, perhaps, but definitely simple: This inflammatory cancer promoter has never been reported in plants.”
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. This is just an approximation of the audio contributed by Ashley Rhinehart, RN.
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See The Inflammatory Meat Molecule Neu5Gc for background and Friday's video-of-the-day How Tumors Use Meat to Grow: Xeno-Autoantibodies for the role it might play in cancer growth. Inflammation (also caused by exogenous endotoxins) is one of the three steps en route to fatal heart disease. See Arterial Acne, Blocking the First Step of Heart Disease, and Making Our Arteries Less Sticky. Antioxidants found predominantly in plants may also decrease inflammation within the body. Nuts may be particularly useful in this regard. Tomorrow we'll close out the Neu5Gc story with Meat May Exceed Daily Allowance of Irony.
For some context, please check out my associated blog post: Plant-Based Diets for Rheumatoid Arthritis
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