Transcript: Optimal Phytosterol Dose
If our enterocyte trash recovery bins are half filled with phytosterols, might vitamins get crowded out too? We didn’t know until last year, but the answer is no, even with a whopping nine gram dose. Vitamin absorption was unaffected. “Plant stanols dose-dependently decrease bad cholesterol concentrations, but not antioxidant concentrations in our blood."
Now nine grams is like ten times what we would expect from even a healthy diet. There's a plateau effect. At that nine grams a day, you’re way out here at then end, but as you can see, the cholesterol-lowering curve starts to flatten out at about two.
So we can pretty much maximize cholesterol-blocking at around two grams, 2000 mg. The standard American diet has been measured as low as 78mg a day. Here’s like a model American Heart Association diet, and this is how high folks eating plant-based diets can get—higher than any other diet pattern reported. That could get you a good 5% reduction, but there’s definitely room to bump that up further if necessary. Those who have improved their diet so much they're no longer eating any cholesterol should be acing their cholesterol tests, but in rare cases your body might not be able to get rid of enough endogenous production. And so doubling phytosterol intake could easily double LDL reduction down to 10%, which could double heart disease risk reduction.
In terms of whole foods sources to maximize cholesterol reduction, seeds provide the most, especially sesame, then nuts, especially pistachio, then legumes like peanuts.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Kerry Skinner.
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