Exposure to mercury during pregnancy appears to influence fetal brain development, as detected by decreased size of a newborn’s brain.
Fish Intake Associated with Brain Shrinkage
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
“All fish contain small amounts of [methylmercury], the most toxic form of mercury, [and] fish consumption represents the main source.” We’ve seen that mercury exposure through fish consumption, even within the governmental safety limits, can have adverse neurological and behavioral effects on child development. And, severe exposure can cause overt structural brain abnormalities like microcephaly, which is a shrunken brain disorder. But we didn’t know whether low exposure could also affect brain size, until this new study.
Autopsy studies suggest mercury preferentially affects the developing cerebellum, and so researchers used ultrasound to measure the brain size in newborns of mothers who had high body levels of mercury, compared to a control group of women who had low levels of mercury. Let’s put that into practical terms.
Compared to the low-level control group, here’s where the high-level mercury women were. How much canned tuna consumption is that equivalent to? Here’s what your body mercury burden is if you eat one serving of canned tuna a day—about half a can. Here’s what two cans a week will do to you. And, this is just one can a week.
So, the bodies of the women suffering high mercury contamination in the ultrasound brain study were considered heavily contaminated, but even just a little canned tuna once in a while could bump your levels even higher. So, the high really wasn’t that high. But still, what did they find?
They demonstrated that newborns born to mothers with higher mercury hair levels had cerebellums up to 14% shorter than those born to mothers with lower mercury hair levels. They conclude that “prenatal exposure to” what may be considered “low-levels of methylmercury does [indeed] influence fetal brain development,” as detected by “decreased size” of a newborn’s brain.
Please consider volunteering to help out on the site.
- S. J. Petre, D. K. Sackett, D. D. Aday. Do national advisories serve local consumers: An assessment of mercury in economically important North Carolina fish. J. Environ. Monit. 2012 14(5):1410 - 1416.
- P. Grandjean, J. E. Henriksen, A. L. Choi, M. S. Petersen, C. Dalgaard, F. Nielsen, P. Weihe. Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes. Epidemiology 2011 22(3):410 - 417.
- D.-H. Lee, I.-K. Lee, K. Song, M. Steffes, W. Toscano, B. A. Baker, D. R. Jacobs Jr. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: Results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006 29(7):1638 - 1644.
- A. Wallin, D. Di Giuseppe, N. Orsini, P. S. Patel, N. G. Forouhi, A. Wolk. Fish consumption, dietary long-chain n-3 fatty acids, and risk of type 2 diabetes: Systematic review and meta-analysis of prospective studies. Diabetes Care. 2012 35(4):918 - 929.
- R. F. White, C. L. Palumbo, D. A. Yurgelun-Todd, K. J. Heaton, P. Weihe, F. Debes, P. Grandjean. Functional MRI approach to developmental methylmercury and polychlorinated biphenyl neurotoxicity. Neurotoxicology 2011 32(6):975 - 980.
- D. A. Axelrad, D. C. Bellinger, L. M. Ryan, T. J. Woodruff. Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data. Environ. Health Perspect. 2007 115(4):609 - 615.
- E. Oken, A. L. Choi, M. R. Karagas, K. Mariën, C. M. Rheinberger, R. Schoeny, E. Sunderland, S. Korrick. Which fish should I eat? Perspectives influencing fish consumption choices. Environ. Health Perspect. 2012 120(6):790 - 798.
- I. B. Cace, A. Milardovic, I. Prpic, R. Krajina, O. Petrovic, P. Vukelic, Z. Spiric, M. Horvat, D. Mazej, J. Snoj. Relationship between the prenatal exposure to low-level of mercury and the size of a newborn's cerebellum. Med. Hypotheses 2011 76(4):514 - 516.
- M. R. Karagas, A. L. Choi, E. Oken, M. Horvat, R. Schoeny, E. Kamai, W. Cowell, P. Grandjean, S. Korrick. Evidence on the human health effects of low-level methylmercury exposure. Environ. Health Perspect. 2012 120(6):799 - 806.
- . J. Strain, P. W. Davidson, M. P. Bonham, E. M. Duffy, A. Stokes-Riner, S. W. Thurston, J. M. W. Wallace, P. J. Robson, C. F. Shamlaye, L. A. Georger, J. Sloane-Reeves, E. Cernichiari, R. L. Canfield, C. Cox, L. S. Huang, J. Janciuras, G. J. Myers, T. W. Clarkson. Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study. Neurotoxicology 2008 29(5):776 - 782.
- A. M. Lando, Y. Zhang. Awareness and knowledge of methylmercury in fish in the United States. Environ. Res. 2011 111(3):442 - 450.
- P. A. Olsvik, H. Amlund, B. E. Torstensen. Dietary lipids modulate methylmercury toxicity in Atlantic salmon. Food Chem. Toxicol. 2011 49(12):3258 - 3271.
- S. D. Stellman, T. Takezaki, L. Wang, Y. Chen, M. L. Citron, M. V. Djordjevic, S. Harlap, J. E. Muscat, A. I. Neugut, E. L. Wynder, H. Ogawa, K. Tajima, K. Aoki. Smoking and lung cancer risk in American and Japanese men: An international case-control study. Cancer Epidemiol. Biomarkers Prev. 2001 10(11):1193 - 1199.
- M. Porta. Persistent organic pollutants and the burden of diabetes. Lancet 2006 368(9535):558-559.
- B. Choi, L. Lapham, L. Amin-Zaki, T. Saleem. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero. J Neuropathol Exp Neurol. 1978 37(6):719-733..
- S. B. Elhassani. The many faces of methylmercury poisoning. J Toxicol Clin Toxicol. 1982 19(8):875 - 906.
- K. Yaginuma-Sakurai, K. Murata, M. Iwai-Shimada, K. Nakai, N. Kurokawa, N. Tatsuta, H. Satoh. Hair-to-blood ratio and biological half-life of mercury: Experimental study of methylmercury exposure through fish consumption in humans. J Toxicol Sci. 2012 37(1):123 - 130.
- D. McAlpine, S. Araki. Minamata disease: An unusual neurological disorder caused by contaminated fish. Lancet 1958 2(7047):629 - 631.
- Inasmasu T, Ogo A, Yanagawa M, Keshino M, Hirakoba A, Takahashi K, Ishinish N. Mercury concentration change in human hair after the ingestion of canned tuna fish. Bull Environ Contam Toxicol. 1986 37(4):475-81.
- Lapham LW1, Cernichiari E, Cox C, Myers GJ, Baggs RB, Brewer R, Shamlaye CF, Davidson PW, Clarkson TW. An analysis of autopsy brain tissue from infants prenatally exposed to methymercury. Neurotoxicology. 1995 16(4):689-704.
- Karimi R, Fitzgerald TP, Fisher NS. A quantitative synthesis of mercury in commercial seafood and implications for exposure in the United States. Environ Health Perspect. 2012 120(11):1512-9.
Images thanks to redjar, Allison Stillwell, Fenderloving, redjar, matthetube and _paVan_ via flickr
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
“All fish contain small amounts of [methylmercury], the most toxic form of mercury, [and] fish consumption represents the main source.” We’ve seen that mercury exposure through fish consumption, even within the governmental safety limits, can have adverse neurological and behavioral effects on child development. And, severe exposure can cause overt structural brain abnormalities like microcephaly, which is a shrunken brain disorder. But we didn’t know whether low exposure could also affect brain size, until this new study.
Autopsy studies suggest mercury preferentially affects the developing cerebellum, and so researchers used ultrasound to measure the brain size in newborns of mothers who had high body levels of mercury, compared to a control group of women who had low levels of mercury. Let’s put that into practical terms.
Compared to the low-level control group, here’s where the high-level mercury women were. How much canned tuna consumption is that equivalent to? Here’s what your body mercury burden is if you eat one serving of canned tuna a day—about half a can. Here’s what two cans a week will do to you. And, this is just one can a week.
So, the bodies of the women suffering high mercury contamination in the ultrasound brain study were considered heavily contaminated, but even just a little canned tuna once in a while could bump your levels even higher. So, the high really wasn’t that high. But still, what did they find?
They demonstrated that newborns born to mothers with higher mercury hair levels had cerebellums up to 14% shorter than those born to mothers with lower mercury hair levels. They conclude that “prenatal exposure to” what may be considered “low-levels of methylmercury does [indeed] influence fetal brain development,” as detected by “decreased size” of a newborn’s brain.
Please consider volunteering to help out on the site.
- S. J. Petre, D. K. Sackett, D. D. Aday. Do national advisories serve local consumers: An assessment of mercury in economically important North Carolina fish. J. Environ. Monit. 2012 14(5):1410 - 1416.
- P. Grandjean, J. E. Henriksen, A. L. Choi, M. S. Petersen, C. Dalgaard, F. Nielsen, P. Weihe. Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes. Epidemiology 2011 22(3):410 - 417.
- D.-H. Lee, I.-K. Lee, K. Song, M. Steffes, W. Toscano, B. A. Baker, D. R. Jacobs Jr. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: Results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006 29(7):1638 - 1644.
- A. Wallin, D. Di Giuseppe, N. Orsini, P. S. Patel, N. G. Forouhi, A. Wolk. Fish consumption, dietary long-chain n-3 fatty acids, and risk of type 2 diabetes: Systematic review and meta-analysis of prospective studies. Diabetes Care. 2012 35(4):918 - 929.
- R. F. White, C. L. Palumbo, D. A. Yurgelun-Todd, K. J. Heaton, P. Weihe, F. Debes, P. Grandjean. Functional MRI approach to developmental methylmercury and polychlorinated biphenyl neurotoxicity. Neurotoxicology 2011 32(6):975 - 980.
- D. A. Axelrad, D. C. Bellinger, L. M. Ryan, T. J. Woodruff. Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data. Environ. Health Perspect. 2007 115(4):609 - 615.
- E. Oken, A. L. Choi, M. R. Karagas, K. Mariën, C. M. Rheinberger, R. Schoeny, E. Sunderland, S. Korrick. Which fish should I eat? Perspectives influencing fish consumption choices. Environ. Health Perspect. 2012 120(6):790 - 798.
- I. B. Cace, A. Milardovic, I. Prpic, R. Krajina, O. Petrovic, P. Vukelic, Z. Spiric, M. Horvat, D. Mazej, J. Snoj. Relationship between the prenatal exposure to low-level of mercury and the size of a newborn's cerebellum. Med. Hypotheses 2011 76(4):514 - 516.
- M. R. Karagas, A. L. Choi, E. Oken, M. Horvat, R. Schoeny, E. Kamai, W. Cowell, P. Grandjean, S. Korrick. Evidence on the human health effects of low-level methylmercury exposure. Environ. Health Perspect. 2012 120(6):799 - 806.
- . J. Strain, P. W. Davidson, M. P. Bonham, E. M. Duffy, A. Stokes-Riner, S. W. Thurston, J. M. W. Wallace, P. J. Robson, C. F. Shamlaye, L. A. Georger, J. Sloane-Reeves, E. Cernichiari, R. L. Canfield, C. Cox, L. S. Huang, J. Janciuras, G. J. Myers, T. W. Clarkson. Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study. Neurotoxicology 2008 29(5):776 - 782.
- A. M. Lando, Y. Zhang. Awareness and knowledge of methylmercury in fish in the United States. Environ. Res. 2011 111(3):442 - 450.
- P. A. Olsvik, H. Amlund, B. E. Torstensen. Dietary lipids modulate methylmercury toxicity in Atlantic salmon. Food Chem. Toxicol. 2011 49(12):3258 - 3271.
- S. D. Stellman, T. Takezaki, L. Wang, Y. Chen, M. L. Citron, M. V. Djordjevic, S. Harlap, J. E. Muscat, A. I. Neugut, E. L. Wynder, H. Ogawa, K. Tajima, K. Aoki. Smoking and lung cancer risk in American and Japanese men: An international case-control study. Cancer Epidemiol. Biomarkers Prev. 2001 10(11):1193 - 1199.
- M. Porta. Persistent organic pollutants and the burden of diabetes. Lancet 2006 368(9535):558-559.
- B. Choi, L. Lapham, L. Amin-Zaki, T. Saleem. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero. J Neuropathol Exp Neurol. 1978 37(6):719-733..
- S. B. Elhassani. The many faces of methylmercury poisoning. J Toxicol Clin Toxicol. 1982 19(8):875 - 906.
- K. Yaginuma-Sakurai, K. Murata, M. Iwai-Shimada, K. Nakai, N. Kurokawa, N. Tatsuta, H. Satoh. Hair-to-blood ratio and biological half-life of mercury: Experimental study of methylmercury exposure through fish consumption in humans. J Toxicol Sci. 2012 37(1):123 - 130.
- D. McAlpine, S. Araki. Minamata disease: An unusual neurological disorder caused by contaminated fish. Lancet 1958 2(7047):629 - 631.
- Inasmasu T, Ogo A, Yanagawa M, Keshino M, Hirakoba A, Takahashi K, Ishinish N. Mercury concentration change in human hair after the ingestion of canned tuna fish. Bull Environ Contam Toxicol. 1986 37(4):475-81.
- Lapham LW1, Cernichiari E, Cox C, Myers GJ, Baggs RB, Brewer R, Shamlaye CF, Davidson PW, Clarkson TW. An analysis of autopsy brain tissue from infants prenatally exposed to methymercury. Neurotoxicology. 1995 16(4):689-704.
- Karimi R, Fitzgerald TP, Fisher NS. A quantitative synthesis of mercury in commercial seafood and implications for exposure in the United States. Environ Health Perspect. 2012 120(11):1512-9.
Images thanks to redjar, Allison Stillwell, Fenderloving, redjar, matthetube and _paVan_ via flickr
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Fish Intake Associated with Brain Shrinkage
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Content URLDoctor's Note
I’ve covered mercury in fish before, in videos such as Nerves of Mercury, and Hair Testing for Mercury before Considering Pregnancy. For more on canned tuna in particular, check out:
- Which Brand of Tuna has the Most Mercury?
- Carcinogenic Putrescine
- The Effect of Canned Tuna on Future Wages
- Amalgam Fillings vs. Canned Tuna
- Mercury in Vaccinations vs. Tuna
What else can we do to protect our newborns? See:
- DDT in Umbilical Cord Blood
- How Fast can Children Detoxify from PCBs?
- The Wrong Way to Detox
- Diet Soda & Preterm Birth
- Meat Fumes: Dietary Secondhand Smoke
But what about the long chain omega-3 DHA in fish—isn’t that necessary for healthy brain development? That’s the topic of my next video, Mercury vs. Omega-3s for Brain Development.
For more context, check out my blog post: Top 10 Most Popular Videos of 2013
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