The green algae, chlorella, may help attenuate the drop in immune function antibodies associated with over-strenuous exercise.
Preserving Athlete Immunity with Chlorella
Sedentary women who start briskly walking on a treadmill 45 minutes a day for a few months may cut their risk of upper respiratory tract infections in half. But how does exercise improve our immune system?
Approximately 95% of all infections are initiated at the mucosal surfaces: like our eyes, nose, and mouth, which are protected by antibodies like IgA, that provide an immunological barrier by neutralizing and preventing viral pathogens from penetrating the body. The IgA in our saliva, for example, is the first line of defense against respiratory tract infections such as pneumonia and influenza.
And moderate aerobic exercise, even just 30 minutes in the gym three times a week, may be all it takes to significantly boost IgA levels and significantly decrease the risk of coming down with flu-like symptoms.
But we’ve known for a long time that prolonged heavy exercise may reduce resistance to infectious disease, manifested by an apparent two to six fold increase in upper respiratory tract infection symptoms for several weeks following marathon running.
Even just a single bout of over strenuous exercise may drop IgA levels. Within one day of starting an international competition, for example, elite soccer players suffered a significant drop in IgA secretion. Yacht racing athletes training for America’s Cup who got upper respiratory tract infections during training had significantly lower IgA concentrations. Those with higher levels had fewer infections, and if you measure over time, you can see dropping levels precede the infection. Furthermore, a simple fatigue rating appears to reflect changes in salivary immunity. If you just ask them, “How rested do you feel?” those who reported feeling worse than normal had significantly lower IgA levels.
Sport coaches are advised to monitor immune function, since illness could ultimately lead to a decrease in performance. Therefore, it may be necessary to take protective actions to, for example, minimize contact with cold viruses. But the reason athletes can’t get away with just washing their hands or wearing a mask is because upper respiratory tract infections are often triggered by reactivations of latent viruses already inside our bodies like Epstein-Barr virus (EBV), and as soon as our immune function dips, the virus becomes reactivated. IgA levels drop the day before EBV comes out of hiding and causes a spike in symptoms. These results suggest that the appearance of upper respiratory symptoms is associated with reactivation of EBV and reduction of salivary IgA during training.
So, how about preserving immunity in athletes? Well, I talked about the efficacy of using a one-celled fungi—nutritional yeast—to boost the immune systems of athletes. What about a one-celled plant?
Research out of Japan found that IgA concentrations in breast milk could be increased by giving mothers chlorella, a unicellular freshwater green algae sold as powder or compressed into tablets. What about other parts of the body? Thirty tablets of chlorella a day for a month increased IgA secretion in the mouth as well. But does that actually help in a clinically meaningful way? Researchers in Canada tried to see if they could boost the efficacy of flu shots, but a chlorella-derived dietary supplement did not appear to have any effect. They were using some purified extract of chlorella, though, not the real thing.
What about giving it to athletes during training camp? High-intensity physical activity, group living—ripe for infection, and indeed the training was so intense IgA levels significantly dropped, but not in those given chlorella each day. So, chlorella intake may attenuate the reduced IgA secretion during athletic training.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. This is just an approximation of the audio contributed by Katie Schloer.
Please consider volunteering to help out on the site.
- T Otsuki, K Shimizu, M Lemitsu, I Kono. Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants. Nutr J. 2012 Dec 11;11:103.
- S A Halperin, B Smith, C Nolan, J Shay, J Kralovec. Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. CMAJ. 2003 Jul 22;169(2):111-7.
- T Otsuki, K Shimizu, M Lemitsu, I Kono. Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study. Nutr J. 2011 Sep 9;10:91.
- T Akimoto, C Nakahori, K Aizawa F Kimura, T Fukubayashi, I Kono. Acupuncture and responses of immunologic and endocrine markers during competition. Med Sci Sports Exerc. 2003 Aug;35(8):1296-302.
- V Neville, M Gleeson, J P Folland. Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Med Sci Sports Exerc. 2008 Jul;40(7):1228-36.
- A Moreira, F Arsati, Y B de Oliveira Lima-Arsati, C G de Freitas, C V de Araujo. J Strength Cond Res. 2011 Jul;25(7):1932-6.
- A Moreira, A L Mortatti, A F Arruda, C G Freitas, M de Arruda, M S Aoki. Salivary IgA response and upper respiratory tract infection symptoms during a 21-week competitive season in young soccer players. J Strength Cond Res. 2014 Feb;28(2):467-73.
- N P Walsh, M Gleeson, R J Shephard, M Gleeson, J A Woods, N C M Fleshner, C Green, B K Pedersen, L Hoffman-Goetz, C J Rogers, H NOrthoff, A Abbasi, P Simon. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev. 2011;17:6-63.
- S Nakano, H Takekoshi, M Nakano. Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin a concentrations in breast milk. J Med Food. 2007 Mar;10(1):134-42.
- R Yamauchi, K Shimizu, F Kimura, M Takemura, K Suzuki, T Akama, I Kono, T Akimoto. Virus activation and immune function during intense training in rugby football players. Int J Sports Med. 2011 May;32(5):393-8.
- D C Neiman, S L Nehlsen-Cannarella, P A Markoff, A J Balk-Lamberton, H Yang, D B Chritton, J W Lee, K Arabatzis. The effects of moderate exercise training on natural killer cells and acute upper respiratory tract infections. Int J Sports Med. 1990 Dec;11(6):467-73.
- P Klentrou, T Cieslak, M Macneil, A Vintinner, M Plyley. Effect of moderate exercise on salivary immunoglobulin A and infection risk in humans. Eur J Appl Physiol. 2002 Jun;87(2):153-8.
Sedentary women who start briskly walking on a treadmill 45 minutes a day for a few months may cut their risk of upper respiratory tract infections in half. But how does exercise improve our immune system?
Approximately 95% of all infections are initiated at the mucosal surfaces: like our eyes, nose, and mouth, which are protected by antibodies like IgA, that provide an immunological barrier by neutralizing and preventing viral pathogens from penetrating the body. The IgA in our saliva, for example, is the first line of defense against respiratory tract infections such as pneumonia and influenza.
And moderate aerobic exercise, even just 30 minutes in the gym three times a week, may be all it takes to significantly boost IgA levels and significantly decrease the risk of coming down with flu-like symptoms.
But we’ve known for a long time that prolonged heavy exercise may reduce resistance to infectious disease, manifested by an apparent two to six fold increase in upper respiratory tract infection symptoms for several weeks following marathon running.
Even just a single bout of over strenuous exercise may drop IgA levels. Within one day of starting an international competition, for example, elite soccer players suffered a significant drop in IgA secretion. Yacht racing athletes training for America’s Cup who got upper respiratory tract infections during training had significantly lower IgA concentrations. Those with higher levels had fewer infections, and if you measure over time, you can see dropping levels precede the infection. Furthermore, a simple fatigue rating appears to reflect changes in salivary immunity. If you just ask them, “How rested do you feel?” those who reported feeling worse than normal had significantly lower IgA levels.
Sport coaches are advised to monitor immune function, since illness could ultimately lead to a decrease in performance. Therefore, it may be necessary to take protective actions to, for example, minimize contact with cold viruses. But the reason athletes can’t get away with just washing their hands or wearing a mask is because upper respiratory tract infections are often triggered by reactivations of latent viruses already inside our bodies like Epstein-Barr virus (EBV), and as soon as our immune function dips, the virus becomes reactivated. IgA levels drop the day before EBV comes out of hiding and causes a spike in symptoms. These results suggest that the appearance of upper respiratory symptoms is associated with reactivation of EBV and reduction of salivary IgA during training.
So, how about preserving immunity in athletes? Well, I talked about the efficacy of using a one-celled fungi—nutritional yeast—to boost the immune systems of athletes. What about a one-celled plant?
Research out of Japan found that IgA concentrations in breast milk could be increased by giving mothers chlorella, a unicellular freshwater green algae sold as powder or compressed into tablets. What about other parts of the body? Thirty tablets of chlorella a day for a month increased IgA secretion in the mouth as well. But does that actually help in a clinically meaningful way? Researchers in Canada tried to see if they could boost the efficacy of flu shots, but a chlorella-derived dietary supplement did not appear to have any effect. They were using some purified extract of chlorella, though, not the real thing.
What about giving it to athletes during training camp? High-intensity physical activity, group living—ripe for infection, and indeed the training was so intense IgA levels significantly dropped, but not in those given chlorella each day. So, chlorella intake may attenuate the reduced IgA secretion during athletic training.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. This is just an approximation of the audio contributed by Katie Schloer.
Please consider volunteering to help out on the site.
- T Otsuki, K Shimizu, M Lemitsu, I Kono. Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants. Nutr J. 2012 Dec 11;11:103.
- S A Halperin, B Smith, C Nolan, J Shay, J Kralovec. Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. CMAJ. 2003 Jul 22;169(2):111-7.
- T Otsuki, K Shimizu, M Lemitsu, I Kono. Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study. Nutr J. 2011 Sep 9;10:91.
- T Akimoto, C Nakahori, K Aizawa F Kimura, T Fukubayashi, I Kono. Acupuncture and responses of immunologic and endocrine markers during competition. Med Sci Sports Exerc. 2003 Aug;35(8):1296-302.
- V Neville, M Gleeson, J P Folland. Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Med Sci Sports Exerc. 2008 Jul;40(7):1228-36.
- A Moreira, F Arsati, Y B de Oliveira Lima-Arsati, C G de Freitas, C V de Araujo. J Strength Cond Res. 2011 Jul;25(7):1932-6.
- A Moreira, A L Mortatti, A F Arruda, C G Freitas, M de Arruda, M S Aoki. Salivary IgA response and upper respiratory tract infection symptoms during a 21-week competitive season in young soccer players. J Strength Cond Res. 2014 Feb;28(2):467-73.
- N P Walsh, M Gleeson, R J Shephard, M Gleeson, J A Woods, N C M Fleshner, C Green, B K Pedersen, L Hoffman-Goetz, C J Rogers, H NOrthoff, A Abbasi, P Simon. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev. 2011;17:6-63.
- S Nakano, H Takekoshi, M Nakano. Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin a concentrations in breast milk. J Med Food. 2007 Mar;10(1):134-42.
- R Yamauchi, K Shimizu, F Kimura, M Takemura, K Suzuki, T Akama, I Kono, T Akimoto. Virus activation and immune function during intense training in rugby football players. Int J Sports Med. 2011 May;32(5):393-8.
- D C Neiman, S L Nehlsen-Cannarella, P A Markoff, A J Balk-Lamberton, H Yang, D B Chritton, J W Lee, K Arabatzis. The effects of moderate exercise training on natural killer cells and acute upper respiratory tract infections. Int J Sports Med. 1990 Dec;11(6):467-73.
- P Klentrou, T Cieslak, M Macneil, A Vintinner, M Plyley. Effect of moderate exercise on salivary immunoglobulin A and infection risk in humans. Eur J Appl Physiol. 2002 Jun;87(2):153-8.
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Preserving Athlete Immunity with Chlorella
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Content URLDoctor's Note
There is, however, a caveat to the use of chlorella. See my last chlorella video Treating Hepatitis C with Chlorella to make up your own mind if the benefits outweigh the risks.
2018 Update: I just published a new video on Detoxifying with Chlorella. Check it out.
Here’s the nutritional yeast study I mentioned: Preserving Immune Function in Athletes With Nutritional Yeast.
Here’s some other ways to decrease your risk of upper respiratory tract infections:
- Can Gargling Prevent The Common Cold?
- Preventing the Common Cold with Probiotics?
- Kiwifruit for the Common Cold
The cuddliest way to protect your immune function, though, may be found in this video: Are Cats or Dogs More Protective For Children’s Health?
What else can exercise do? See videos like Longer Life Within Walking Distance and Exercise vs. Drugs for Depression.
More on how to reap the wondrous benefits of exercise in:
- Standing Up for Your Health
- Enhanced Athletic Recovery Without Undermining Adaptation
- Paleo Diets May Negate Benefits of Exercise
UPDATE: Some chlorella supplements have been found to contain unacceptable levels of contamination with toxin-producing species of algae, so I would recommend against consuming it. Video forthcoming…
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