Lower cancer rates among those eating a plant-based diet may be a result of reduced blood levels of IGF-1 and enhanced production of IGF-1 binding protein.
The Answer to the Pritikin Puzzle,
Remember the Pritikin experiments? You put people on a plant-based diet and exercise and in as little as 12 days you can turn their bloodstream into a cancer cell fighting machine. Here's the before picture, a layer of breast cancer cells is laid downin a petri dish and then blood from women eating the standard American diet is dripped on them, and as you can see, even people eating crappy diets have some ability to break down cancer. But after just 12 days eating healthy, blood was drawn from those same women, dripped on another carpet of breast cancer cells and this is what you're left with. Their bodies cleaned up!
You can also look at it another way. This is what's called terminal-deoxynucleotidyl-transferase-dUTP-nick-end-labeling or "tunel" imaging, which measures DNA fragmentation, cell death. Dying cells show up as white spots. So again, this is the before, what the blood of your average woman can do to breast cancer cells. If can kill of a few. But then after 12 days of healthy plant-based living their blood can do this.
This is called programmed cancer cell death. After eating healthy, their own bodies were able to reprogram the cancer cells—forcing them into early retirement. It’s like you’re an entirely different person inside. How does a simple dietary change make one’s bloodstream so inhospitable to cancer in just a matter of days? That, was the next question they set out to answer, and they finally did, in 2011... “Here we sought to determine the underlying mechanisms for these anticancer effects.” And what they came up with was IGF-1.
If you measure the blood levels of Insulin Like Growth Factor One before and after 11 days on a plant-based diet with exercise, IGF-1 levels significantly drop. And, IGF-1 binding protein levels, significantly rise. That’s one way our body tries to protect itself from cancer—from excessive growth—by releasing a binding protein into our bloodstream to tie up IGF-1. It's like our body’s emergency brake. Yeah sure, in as little as 11 days a healthy diet can reprogram your body to slow down IGF-1 production, but you still have all that IGF-1 circulating in your bloodstream from the bacon and eggs you had the week before. So your liver releases a snatch squad of binding proteins to take it out of circulation pronto. Exercise alone can drop IGF-1 levels, but you need the plant based diet to get those kind of snatch squad levels.
And so with that combination, 20% less IGF-1, and 50% more IGF binding protein, no wonder there was such a dramatic cancer cell die-off after just a few days.
So did they solve the riddle, did they figure out how a plant-based diet shuts down cancer growth? Well the definitive study wasn’t published until recently.
Same as last time; before and after a few weeks of a plant-based diet. Cancer cell growth drops; programmed cancer cell death, shoots up. But then here’s the kicker. Remember how IGF1 levels dropped? Well, what if you add that exact same amount of IGF1 back in with the cancer? … It erases the diet and exercise effect. It’s like you never started eating healthy at all. Now if cancer growth just came back down to here you’d think OK, IGF was part of it, but the fact that it eliminated the effects of the lifestyle changes, suggests that that was the mechanism all along: Walking, and eating a plant based diet for just a few days, lowers circulating IGF1 levels, which then can reverse cancer growth.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Kerry Skinner.
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Who is Pritikin? See Engineering a Cure. What's the puzzle? SeeDeveloping an Ex Vivo Cancer Proliferation Bioassay and Prostate Versus a Plant-Based Diet. What's the big deal about IGF-1? See IGF-1 as One-Stop Cancer Shop and Cancer-Proofing Mutation. The binding protein findings may explain the conclusion in Is It the Diet, the Exercise, or Both?. As I covered in my full-length 2012 presentation Uprooting the Leading Causes of Death, tomorrow's video-of-the-day How Plant-Based to Lower IGF-1? will go a level deeper and explore why eating plants lowers IGF-1.
For some context, please check out my associated blog posts: Top 10 Most Popular Videos of the Year, Cancer-Proofing Your Body, How Do Plant-Based Diets Fight Cancer?, Animal Protein and the Cancer Promoter IGF-1, Vegan Men: More Testosterone But Less Cancer, Vegan Men: More Testosterone But Less Cancer, How Much Soy Is Too Much?, Eating Green to Prevent Cancer, Are Bioidentical Hormones Safe?, and How Tumors Use Meat to Grow
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