Doctor's Note

Be sure to check out Glycotoxins, the first video of this series on AGEs.  

For further context, check out my associated blog post: Harvard’s Meat and Mortality Studies.

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  • Michael Greger M.D.

    Please feel free to post any ask-the-doctor type questions here in the comments section and I’d be happy to try to answer them. Be sure to check out “part 1” on AGEs in Glycotoxins. And there are 1,449 subjects covered in the rest of my videos–please feel free to explore them!

  • Loved this video – posting it on FB in hopes that my “friends” will be vegucated….. Would love to see what you have to say about pyroluria and you take on it. I worked in mental health and there was no mention of pyroluria being a factor in mental health…..I feel this is an issue that needs a spotlight – providing millions of sufferers with an healthful alternative to the psych drugs, you know, with the side effects which then require more medications……….you know the story.

  • chewy

    are AGES in rice cakes,air popped popcorn, plain puffed grains?

  • becochic

    How can I view the database?
    I noticed one source said milk was low… wonder why that is, but it is higher in cheese?

    Also, I want to sign in with fb, but the button won’t work.

  • becochic

    Never mind. I got it. I’m going to stay enrolled in college forever for access to all these awesome journals online. ;)

  • paul3917

    I’d be interested in knowing how raw nuts and seeds compare to roasted ones. I remember you recommending that we roast our nuts to take advantage of better mineral absorption of roasted nuts. But if AGE’s are too high as a result of roasting, I’d rather get my minerals from some other source.

    • Steph

      According to the chart, roasted nuts are indeed higher in AGEs compared to raw nuts. Perhaps eating a mixture of raw and roasted nuts is best?

      • Best is to soak nuts overnight in the fridge, so you get them easier to digest and enhance nutrient absorption AND also soaking does need not need any heat so there aren’t AGEs produced :)

  • Mike Quinoa
    • Michael Greger M.D.

      Thanks Mike–I changed the link. All thanks to you!

  • vegimator

    I posted this in the previous glycation thread, but I’ll post it again here. If you do some googling, it’s evident that vegetarians and vegans have higher AGE levels than omnis because they consume taurine which drastically lowers AGE levels. So it might be a good idea to take taurine.

    • Lily

      interesting. Dr. Greger – what are your thoughts on this?

      • The pilot studies (here and here) that found higher levels in vegetarians appears to have been a fluke. A larger study performed by the same research group (90 vegetarians compared to the originals involving 19) did not find significantly higher AGE levels. McCarty’s hypothesis paper about taurine was published before the new data came out.

        • Nathan Hart

          Is there any benefit for a vegan supplementing taurine?

    • Yes, Dr. Greger — any thoughts? I’ve seen taurine recommended for vegans before but know nothing about this.

    • The link you cite says:
      “Thus, a taurine supplemented low-fat vegan diet may be recommended as a strategy for minimizing AGE-mediated complications in diabetics and in patients with renal failure.”

      I don’t know how this applies to those who aren’t diabetic or have renal failure. Maybe the full text explains more but that costs money to read.

    • The one study that found higher levels in vegetarians appears to have been a fluke. A larger study performed by the same research group (90 vegetarians compared to the original 19) did not find significantly higher AGE levels. McCarty’s hypothesis paper bout taurine was published before the new data came out.

  • Michael Greger M.D.

    For some context, please check out my associated blog post Harvard’s Meat and Mortality Studies!

  • Kar

    I have diabetes type 1 ,and I`d like to know weather there are specific foods or substances or supplements that counter balance the accelerated production of AGEs in the body of a diabetic.In other words,things I can do to go against AGEs.
    The AGEs created by the hyperglycemia. Not just the AGEs found in foods.
    Thank you very much.

  • blackbart

    Wrong wrong wrong. Glycation comes from sugar, not protein or fat.

  • richard maddux

    What is on your menu? Go have lunch with ALz. patient.

  • macbev

    This video is called avoiding a sugary grave, but nowhere in it is sugar actually mentioned. What’s the deal?

    • Brigitte

      HI macbev!
      Maybe it’s not to be taken literally…

    • Name

      Advanced Glycation End products (AGEs) are when sugar molecules have attached to other
      molecules, usually amino acids or proteins in this case. The term glycation is
      usually what confuses people, but it is referring to sugars(

  • Hiram Ruiz MD

    Since we don’t know what is a safe intake of glycoproteins.And since we don’t know how much glycoprotein we are producing endogenously;suggesting
    cutting to one half just to extend lifespan is like dealing with the enemy.Cutting in half does not heal any disease and it doesn’t say anything about improving quality of life.The Life Style Change that will heal many of these toxicoinflammatory disorders ,and provide an improved quality extended
    life span is a Plant Based Diet without highly loaded Leucine-Casein-Arachidonic Acid containing foods.Just by substituting meats,milk products and simple carbohydrates you may help prevent,stop and heal many of these conditions ,and live a high quality extended lifespan.

  • Excellent information, tweeting it out.

  • Blaice

    The AGEs in tofu is alarming to me. It is similar or more than meat. It saddens me because I love to make tofu in a bake with vegetables, brown rice, red rice, and lentils…

    • lilyroza

      I wonder if that’s because it doesn’t have fiber in it? But the worst AGEs are when it’s broiled or sauteed, if it’s raw or steamed, much less AGEs. Wonder how many AGEs in edamame.

  • Ivan Washington

    as jack lalanne [RIP] was fond of saying, “if it tastes good, spit it out!”

  • aprolifer

    It’s previously been my understanding that more AGEs are formed in the body by the chemical combination of proteins and sugars in the diet than are ingested by consuming specific foods that already have them. Is this true or not?

  • John Smith

    Interesting article about glycotoxins, but why is it entitled “Avoiding a Sugary Grave” when it seems to be mostly about avoiding eating meat particularly browned meat?

  • mac

    I have been on a plant based diet for 4 years and although I’ve lost weight and my Type 1 diabetes has disappeared the one thing that doesn’t seem to change is my blood pressure figure. It has stayed high all the time, high being in a range from 130 to 158 and 82 to 98.
    I am still on Ramapril;Metropolol-l;Diltiazem and warfarin. (I was diagnosed with AFib 5 years ago although I have had no recurrence of the symptoms since then.)
    I’m beginning to think that I’m one of these people who doesn’t get benefit from a plant based diet – in relation to hypertension?

  • Elishevah Godfrey

    Great video as always! Thanks!
    …not sure how the title “How to Avoid a Sugary Grave” connects with the content.

  • Hmm… According to Dr. D’Adamo’s observations (which occurred BEFORE these studies) people with type B blood tend to have more health problems relating to the brain. He also advised against eating chicken for them… DECADES ago. I realize these observations don’t prove anything and will be dismissed by those “needing” proof, but observation and philosophy lead science, not usually the other way around. Food for THOT! :-)