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Cancer, Interrupted: Green Tea

Using the cooked meat carcinogen PhIP to turn normal breast cells cancerous, researchers explore the use of green tea to interrupt this malignant transformation.

January 25, 2013 |
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Cancer, Interrupted: Green Tea , 5.0 out of 5 based on 4 ratings

Sources Cited

S. Choudhary, S. Sood, R. L. Donnell, H.-C. R. Wang. Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis 2012 33(4):876 - 885

M. Kurzawa-Zegota, M. Najafzadeh, A. Baumgartner, D. Anderson. The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food Chem. Toxicol. 2012 50(2):124 - 129

P. Zhou, J.-P. Li, C. Zhang. Green tea consumption and breast cancer risk: Three recent meta-analyses. Breast Cancer Res. Treat. 2011 127(2):581 - 583

C. Wilson, A. Aboyade-Cole, O. Newell, E. Darling-Reed, E. Oriaku, R. Thomas. Diallyl sulfide inhibits PhIP-induced DNA strand breaks in normal human breast epithelial cells. Oncology Reports 2007 17(NA):807-811

C. Y. Lyou, Nariya Cho, S. M. Kim, M. Jang, J-S. Park, S. Y. Baek, W. K. Moon. Computer-Aided Evaluation of Breast MRI for the Residual Tumor Extent and Response Monitoring in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy. Korean J Radiol. 2011 Jan-Feb; 12(1): 34–43.

Acknowledgements

たね via Wikimedia Commons, Annie Cavanagh. via Wellcome Images

Transcript

More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens, such as those in the diet, through a multistep disease process progressing from non-cancerous to premalignant and malignant stages. Now we know that the chemical carcinogen (PhIP) is one of the most abundant heterocyclic amines found in high-temperature cooked meats and is recognized as a breast carcinogen. However, the PhIP’s mechanism of action in breast cell carcinogenesis is not clear. How does it do it? Well in this landmark new study they "demonstrated, for the first time, that cumulative exposures to PhIP at effectively induced progressive carcinogenesis, cancer transformation of human breast cells from a non-cancerous stage to premalignant and malignant stages in a dose- and exposure-dependent manner.” They started out with normal human breast cells. And were able to transmute them completely into cancer cells just using that cooked meat carcinogen found predominantly in fried bacon, fish, and chicken. That's all it took, and Jekyll becomes Hyde. Now PhIP was already established as a carcinogen, the reason they did this was to develop a model of ''human breast cancer carcinogenesis", from beginning to end to test various interventions to see if we can somehow stop this process of cancer formation. For example, three recent meta-analyses reviewing all the epidemiological, or population-based evidence concerning green tea consumption and breast cancer risk concluded that green tea consumption may be protective.  Well let's put it to the test. Here's the response of normal breast cells to repeated exposure to the cooked meat carcinogen PhIP using six different measures of cancerous qualities. They all go up—but, if you add a little green tea phytonutrients, the transformation to breast cancer is blunted, it was indeed "effective in suppressing PhIP-induced cellular carcinogenesis and tumorigenicity.”

To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Jonathan Hodgson.

To help out on the site please email volunteer@nutritionfacts.org

Dr. Michael Greger

Doctor's Note

What is this PhIP stuff? See the last four videos for some background:

Any other feats green tea can pull off? See Treating Genital Warts With Green Tea and Treating Gorlin Syndrome With Green Tea.

Might white tea work even better? See Antimutagenic Activity of Green Versus White Tea.

Any other plants that might be able to smack on the cancer kibosh? (I mean besides broccoli, so for example: DNA Protection from Broccoli and Broccoli Versus Breast Cancer Stem Cells). Stay tuned for my next video Cancer, Interrupted: Garlic & Flavonoids.

If you haven't yet, you can subscribe to my videos for free by clicking here.

PS: Those of you with mobile devices will have noticed immediately the major upgrade to NutritionFacts.org yesterday. The entire site has been redesigned to incorporate "responsive web design." This means NutritionFacts.org will now automatically resize to fit whatever device you're on. There are now close to 50 million people in the U.S. alone that watch videos on their mobile devices. Sure we could make a special iphone app, an ipad app, an android app, but there are now thousands of smartphones and tablets out there. Enter: responsive web design. NutritionFacts.org now automatically resizes to fit your screen--any screen! Try resizing your browser right now. See? Isn't that cool?! Thanks go to our resident web designer genius Christi Richards and the generous support of The Jesse and Julie Rasch Foundation, without which NutritionFacts.org wouldn't even exist.

  • Rick

    Thank you! How much green tea? And in what form?

    • Coacervate

      Click on Green Tea in the list to the left of this page. it will take you here http://nutritionfacts.org/topics/green-tea/

      about 10 cups per day is probably the safe upper limit. Cold brewing is best. If you are antioxidant-low to start, as I was, you’ll start feeling improvement in general after 3 days. Break the good habit, as I did, and general decrease in “tone” returns.

      Good luck!

  • http://www.facebook.com/skowarsky Steve Kowarsky

    Truly amazing and much appreciated! Great graphics, by the way. Can we infer that if you don’t eat meat and drink green tea, the cancer risk goes down? Studies?

    • Coacervate

      Well, tis most certainly implied…by the studies so cited. ?

  • Catherine J Frompovich

    As part of my holistic only protocol for dealing with two cancerous tumors in my right breast, which I’ve ungrown to almost nothing and document in my book A Cancer Answer, Holistic BREAST Cancer Management, A Guide to Effective & Non-Toxic Treatments, I drank a large mug of ORGANIC green tea three (3) times a day. I would steep loose tea; I did not brew it in a tea bag. If you buy organic green tea in a tea bag, cut open the bag and place the tea into a stainless steel diffuser and brew it that way.
    Green tea enhances by eight times the effectiveness of curcumin (turmeric) and curcumin enhances green tea’s effectiveness by three times. There’s a lot to be said for green tea in managing cancer, I say and have experienced.

  • http://www.facebook.com/profile.php?id=518021344 Cheyanne Imbriaco

    Does the study indicate how much green tea was utilized in the study? Such as how much would one have to drink as a preventative measure?

  • jane

    Does it matter whether the tea is decaffeinated?

  • Chokyi Dawa

    I’d like to say “Thank You” to The Jesse and Julie Rasch Foundation for making these video’s possible.

    I wonder how many people are in this community? What if we all donated $10.00 would that be enough to return to daily video’s?

    Maybe the funding for this site needs to be 3 legged: Dr Greger, Rasch Foundation and the Community members that benefit from the video’s.

    With Gratitude to all involved in this community.<;-)

    • Veganrunner

      Well said Chokyi!

      We get so much useful information from this nutrition website. Just click on the donation page. It is so easy!

      • dogsnoseknows

        Did it, done! I’d also like to thank the Rausch Foundation, along with those who contribute money and/or time, including those such as Jonathan Hodgson who make the transcripts of the videos available to those of us without a broadband connection. Much appreciated!

        • Veganrunner

          Yeah!

  • tea

    What about the effect of tea on the good bacteria in the gut? Dr. Klaper warns that tea has a deadly effect on the gut flora.

  • http://blessedveganlife.blogspot.com BlessedMama

    I’m so glad you are putting these videos out. Hopefully this one will save the life of at least one woman.

  • Lawrence

    Dr. Greger: given that hibiscus tea is so much more potent than green tea (per your ‘Better than Green Tea?’ video), are there reasons to believe that hibiscus tea would have similar or greater anti-cancer effects as those shown in this video? Thank you.

  • Gwynneth

    Does adding Hemp Milk to my Green Tea impact its health benefits? Thank You.

  • Mark

    Well, since there is no ‘general mailbox’ in which to ask ‘related’ questions…

    Any comments regarding the enhanced anti-oxidant effectiveness of catechins as a result of adding fruit juice (vitC):

    “Common Tea Formulations Modulate In Vitro Digestive Recovery of Green Tea Catechins” by Mario Ferruzzi, et al.

    Also, of the results from Nam Dang, M.D., Ph.D., University of Florida researcher regarding the anti-cancer characteristics of papaya leaf/bark tea…

    Thanks

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