Advanced glycation end products (AGEs) in our diet are thought to accelerate the aging process.
500 foods were tested for advanced glycation end products (AGEs).
Advanced glycation end products, AGE’s, appropriately acronymed, as they are considered gerontotoxins, geronto as in gerontology, these are aging toxins, thought to accelerate the aging process, the multisystem decline in anatomic integrity and function. AGE’s crosslink proteins together causing tissue stiffness, oxidative stress and inflammation. In the brain they may contribute to dementia, in the eye cataracts and macular degeneration. In the arteries and heart, hypertension, atherosclerosis, heart failure and stroke, then anemia, kidney disease, osteoporosis and muscle loss.
There are two sources of these toxins. One, we can’t do much about—they’re produced internally as natural waste products of metabolism, but source number 2 is our diet.
Research in the 70’s on rats found that AGE’s weren’t absorbed very well and so dietary sources were dismissed as irrelevant, until 25 years later when we finally tested people, and low and behold, we found that diet-derived AGEs that are absorbed into the bloodstream may represent a major source of chemically and biologically active toxins. and so we should eliminate the foods and modes of cooking associated with the highest AGE content.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by MaryAnn Allison.
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Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H. Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6474-9.
Krautwald M, Münch G. Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxal-lowering agents for Alzheimer's disease? Exp Gerontol. 2010 Oct;45(10):744-51. Epub 2010 Mar 6.
Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010 Jun;110(6):911-16.e12.
Please feel free to post any ask-the-doctor type questions here in the comments section and I’d be happy to try to answer them. Be sure to check out other videos on aging. And there are 1,449 subjects covered in the rest of my videos–please feel free to explore them!
Check out my associated blog post for more context: Which Common Fruit Fights Cancer Better?
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