All plants produce “phytochelatins” to bind up heavy metals to protect themselves from the harmful effects, so what if we ate the plants?
Best Foods for Lead Poisoning: Chlorella, Cilantro, Tomatoes, Moringa?
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
There are so-called chelation drugs you can give for acute life-threatening lead poisoning, like if your two-year-old swallows a little lead weight, because grandma was “sewing curtains,” and your doctor happened to miss it on x-ray, and so, it sat there until she died, with a blood lead level over 200.
But for lower grade, chronic lead poisoning, like levels under 45, there was no clear guidance as to whether these chelation drugs were effective. So, they were put to the test. And, they failed to bring down lead levels long term. Even when they worked initially, in dose after dose, the lead continued to apparently seep from their bones, and by the end of the year, they ended up with the same lead levels as the sugar pill group. So, no surprise that even though blood levels dipped at the beginning, no improvements in cognitive function or development could be found.
Since much of lead poisoning is “preventable,” and the drugs don’t seem to work in most cases, that just underscores the need “to protect children from exposure to lead in the first place.” Despite the medical profession’s “best intentions to do something to help these kids,…drug therapy is not the answer.” Yeah, “[w]e need to redouble…efforts to prevent lead poisoning in the first place,” but what can we do for the kids who’ve already been exposed?
“The currently approved…method…[these] chelating agents, which bind and remove lead from our tissues,…lack safety and efficacy when [these] conventional chelating agents are used.” So, what about dietary approaches? See, plants produce phytochelatins. “All higher plants…possess the capacity to synthesize” compounds that bind up heavy metals to protect themselves from the harmful effects. So, what if we ate the plants? “Unlike other forms of treatment [like] pharmacotherapy with drugs, nutritional strategies carry the promise of a natural form of therapy that would presumably be cheap and with few [or] no side effects.” Yeah, but would it work? The drugs didn’t.
We learned that a meal could considerably cut down on lead absorption, but “the particular components of food intake that so dramatically reduce lead absorption” was uncertain at the time. The calcium content of the meal appeared to be part of it, but milk didn’t seem to help, and even made things worse.
So, how about calcium supplements? There are those that assert calcium supplements may help, but “recommendations…must be based on evidence rather than conviction.” And, those assertions are, in part, based on studies on rodents, and “differences in calcium absorption and [balance] between rats and humans” make “extrapolation” tricky. What you have to do is put it to the test. And, even an extra whopping 1,800mg a day of calcium had “no effect” on blood lead levels. So, the evidence “does not support” calcium supplements helping.
What about whole foods? Reviews of “dietary strategies” to treat lead toxicity say things like eat lots of tomatoes, and berries, and onions, and garlic, and grapes, as they’re natural antagonists to lead toxicity and, therefore, should be consumed on a regular basis. Remember those phytochelatins? So, maybe eating plants might help detoxify the lead in our own bodies or the bodies of those whom we eat. Maybe we could feed tomatoes, berries, onions, garlic, grapes to cows, pigs, chickens, and fish, and reduce our lead exposure that way.
These natural phytochelatin compounds work so well that we can use them to clean up pollution. For example, chlorella can suck up lead and hold onto it; so, what if we ate it? If it can clean up polluted bodies of water, might it clean up our own polluted body? We don’t know, because all we have are studies like this—of mice, not men.
So, when you hear about how chlorella is detoxifying, they’re talking about the detoxification of rat testicles. So, yeah, a little sprinkle of chlorella might help your pet rat, or some black cumin seeds, or a sprig of cilantro. But when you hear about how cilantro is detoxifying against heavy metals, I presume you don’t expect them to be talking about studies like this. But if we’re interested in scientists protecting our children, not just their pets, we’re out of luck.
Same with moringa. Same with tomatoes, and flax seed oil, and sesame seed oil. Same with black grapes, and black, white, green, and red tea. There are simply no human studies to guide us. Dietary strategies for the treatment of lead toxicity are typically just based on studies on rats, mice, rats, rats, rats, rats, rats, rats. But there are some human studies—promising human studies, that I’ll explore—next.
Please consider volunteering to help out on the site.
- Mahaffey KR. Environmental lead toxicity: nutrition as a component of intervention. Environ Health Perspect. 1990 Nov;89:75-8.
- James HM, Hilburn ME, Blair JA. Effects of meals and meal times on uptake of lead from the gastrointestinal tract in humans. Hum Toxicol. 1985 Jul;4(4):401-7.
- Zhai Q, Narbad A, Chen W. Dietary strategies for the treatment of cadmium and lead toxicity. Nutrients. 2015 Jan 14;7(1):552-71.
- Gupta VK, Singh S, Agrawal A, Siddiqi NJ, Sharma B. Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals. Biochem Res Int. 2015;2015:534769.
- Lakshmi BV, Sudhakar M, Aparna M. Protective potential of Black grapes against lead induced oxidative stress in rats. Environ Toxicol Pharmacol. 2013 May;35(3):361-8.
- Winiarska-Mieczan A. The potential protective effect of green, black, red and white tea infusions against adverse effect of cadmium and lead during chronic exposure - A rat model study. Regul Toxicol Pharmacol. 2015 Nov;73(2):521-9.
- Mabrouk A, Ben Cheikh H. Thymoquinone supplementation reverses lead-induced oxidative stress in adult rat testes. Gen Physiol Biophys. 2015 Jan;34(1):65-72.
- Chandrasekaran VR, Hsu DZ, Liu MY. Beneficial effect of sesame oil on heavy metal toxicity. JPEN J Parenter Enteral Nutr. 2014 Feb;38(2):179-85.
- Nwokocha CR, Nwokocha MI, Aneto I, Obi J, Udekweleze DC, Olatunde B, Owu DU, Iwuala MO. Comparative analysis on the effect of Lycopersicon esculentum (tomato) in reducing cadmium, mercury and lead accumulation in liver. Food Chem Toxicol. 2012 Jun;50(6):2070-3.
- Sharma V, Kansal L, Sharma A. Prophylactic efficacy of Coriandrum sativum (Coriander) on testis of lead-exposed mice. Biol Trace Elem Res. 2010 Sep;136(3):337-54.
- Velaga MK, Daughtry LK, Jones AC, Yallapragada PR, Rajanna S, Rajanna B. Attenuation of lead-induced oxidative stress in rat brain, liver, kidney and blood of male Wistar rats by Moringa oleifera seed powder. J Environ Pathol Toxicol Oncol. 2014;33(4):323-37.
- Abdel Moneim AE, Dkhil MA, Al-Quraishy S. Effects of flaxseed oil on lead acetate-induced neurotoxicity in rats. Biol Trace Elem Res. 2011 Dec;144(1-3):904-13.
- O'Connor ME, Rich D. Children with moderately elevated lead levels: is chelation with DMSA helpful? Clin Pediatr (Phila). 1999 Jun;38(6):325-31.
- Henretig F. Lead poisoning prevention, not chelation (commentary). J Toxicol Clin Toxicol. 2001;39(7):659-60.
- Rosen JF, Mushak P. Primary prevention of childhood lead poisoning--the only solution. N Engl J Med. 2001 May 10;344(19):1470-1.
- McKay CA Jr. Role of chelation in the treatment of lead poisoning: discussion of the Treatment of Lead-Exposed Children Trial (TLC). J Med Toxicol. 2013 Dec;9(4):339-43.
- Rogan WJ, Dietrich KN, Ware JH, Dockery DW, Salganik M, Radcliffe J, Jones RL, Ragan NB, Chisolm JJ Jr, Rhoads GG; Treatment of Lead-Exposed Children Trial Group. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med. 2001 May 10;344(19):1421-6.
- [No authors listed] Effect of lactose on intestinal absorption of lead. Nutr Rev. 1982 Apr;40(4):116-7.
- Ballew C, Bowman B. Recommending calcium to reduce lead toxicity in children: a critical review. Nutr Rev. 2001 Mar;59(3 Pt 1):71-9.
- Queiroz ML, da Rocha MC, Torello CO, de Souza Queiroz J, Bincoletto C, Morgano MA, Romano MR, Paredes-Gamero EJ, Barbosa CM, Calgarotto AK. Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice. Food Chem Toxicol. 2011 Nov;49(11):2934-41.
- Suresh Kumar K, Dahms HU, Won EJ, Lee JS, Shin KH. Microalgae - A promising tool for heavy metal remediation. Ecotoxicol Environ Saf. 2015 Mar;113:329-52.
- Ahamed M, Siddiqui MK. Environmental lead toxicity and nutritional factors. Clin Nutr. 2007 Aug;26(4):400-8. Epub 2007 May 17.
- Hu H, Kotha S, Brennan T. The role of nutrition in mitigating environmental insults: policy and ethical issues. Environ Health Perspect. 1995 Sep;103 Suppl 6:185-90.
- Markowitz ME, Sinnett M, Rosen JF. A randomized trial of calcium supplementation for childhood lead poisoning. Pediatrics. 2004 Jan;113(1 Pt 1):e34-9.
- Olusola BO, Aransiola MN. Biosorption of Lead (Pb2+) from Industrial Effluent using Green Algae. International Journal of Science and Research (IJSR) ISSN (Online): 2319-7064.
- Aung WL, Hlaing NN, Aye KN. Biosorption of Lead (Pb2+) by using Chlorella vulgaris. International Journal of Chemical, Environmental & Biological Sciences (IJCEBS) Volume 1, Issue 2 (2013) ISSN 2320 –4087 (Online).
- Cobbett CS. Phytochelatins and their roles in heavy metal detoxification. Plant Physiol. 2000 Jul;123(3):825-32.
- Mustafa HN. Potential Alleviation of Chlorella vulgaris and Zingiber officinale on Lead-Induced Testicular Toxicity: an Ultrastructural Study. Folia Biol (Krakow). 2015;63(4):269-78.
- Hugelmeyer CD, Moorhead JC, Horenblas L, Bayer MJ. Fatal lead encephalopathy following foreign body ingestion: case report. J Emerg Med. 1988;6(5):397-400.
Icons created by Francisca Arévalo, Nikita Kozin, Symbolon, and Evan MacDonald from the Noun Project.
Image credit: S. Alexis via Flickr. Image has been modified.
Motion graphics by Avocado Video.
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
There are so-called chelation drugs you can give for acute life-threatening lead poisoning, like if your two-year-old swallows a little lead weight, because grandma was “sewing curtains,” and your doctor happened to miss it on x-ray, and so, it sat there until she died, with a blood lead level over 200.
But for lower grade, chronic lead poisoning, like levels under 45, there was no clear guidance as to whether these chelation drugs were effective. So, they were put to the test. And, they failed to bring down lead levels long term. Even when they worked initially, in dose after dose, the lead continued to apparently seep from their bones, and by the end of the year, they ended up with the same lead levels as the sugar pill group. So, no surprise that even though blood levels dipped at the beginning, no improvements in cognitive function or development could be found.
Since much of lead poisoning is “preventable,” and the drugs don’t seem to work in most cases, that just underscores the need “to protect children from exposure to lead in the first place.” Despite the medical profession’s “best intentions to do something to help these kids,…drug therapy is not the answer.” Yeah, “[w]e need to redouble…efforts to prevent lead poisoning in the first place,” but what can we do for the kids who’ve already been exposed?
“The currently approved…method…[these] chelating agents, which bind and remove lead from our tissues,…lack safety and efficacy when [these] conventional chelating agents are used.” So, what about dietary approaches? See, plants produce phytochelatins. “All higher plants…possess the capacity to synthesize” compounds that bind up heavy metals to protect themselves from the harmful effects. So, what if we ate the plants? “Unlike other forms of treatment [like] pharmacotherapy with drugs, nutritional strategies carry the promise of a natural form of therapy that would presumably be cheap and with few [or] no side effects.” Yeah, but would it work? The drugs didn’t.
We learned that a meal could considerably cut down on lead absorption, but “the particular components of food intake that so dramatically reduce lead absorption” was uncertain at the time. The calcium content of the meal appeared to be part of it, but milk didn’t seem to help, and even made things worse.
So, how about calcium supplements? There are those that assert calcium supplements may help, but “recommendations…must be based on evidence rather than conviction.” And, those assertions are, in part, based on studies on rodents, and “differences in calcium absorption and [balance] between rats and humans” make “extrapolation” tricky. What you have to do is put it to the test. And, even an extra whopping 1,800mg a day of calcium had “no effect” on blood lead levels. So, the evidence “does not support” calcium supplements helping.
What about whole foods? Reviews of “dietary strategies” to treat lead toxicity say things like eat lots of tomatoes, and berries, and onions, and garlic, and grapes, as they’re natural antagonists to lead toxicity and, therefore, should be consumed on a regular basis. Remember those phytochelatins? So, maybe eating plants might help detoxify the lead in our own bodies or the bodies of those whom we eat. Maybe we could feed tomatoes, berries, onions, garlic, grapes to cows, pigs, chickens, and fish, and reduce our lead exposure that way.
These natural phytochelatin compounds work so well that we can use them to clean up pollution. For example, chlorella can suck up lead and hold onto it; so, what if we ate it? If it can clean up polluted bodies of water, might it clean up our own polluted body? We don’t know, because all we have are studies like this—of mice, not men.
So, when you hear about how chlorella is detoxifying, they’re talking about the detoxification of rat testicles. So, yeah, a little sprinkle of chlorella might help your pet rat, or some black cumin seeds, or a sprig of cilantro. But when you hear about how cilantro is detoxifying against heavy metals, I presume you don’t expect them to be talking about studies like this. But if we’re interested in scientists protecting our children, not just their pets, we’re out of luck.
Same with moringa. Same with tomatoes, and flax seed oil, and sesame seed oil. Same with black grapes, and black, white, green, and red tea. There are simply no human studies to guide us. Dietary strategies for the treatment of lead toxicity are typically just based on studies on rats, mice, rats, rats, rats, rats, rats, rats. But there are some human studies—promising human studies, that I’ll explore—next.
Please consider volunteering to help out on the site.
- Mahaffey KR. Environmental lead toxicity: nutrition as a component of intervention. Environ Health Perspect. 1990 Nov;89:75-8.
- James HM, Hilburn ME, Blair JA. Effects of meals and meal times on uptake of lead from the gastrointestinal tract in humans. Hum Toxicol. 1985 Jul;4(4):401-7.
- Zhai Q, Narbad A, Chen W. Dietary strategies for the treatment of cadmium and lead toxicity. Nutrients. 2015 Jan 14;7(1):552-71.
- Gupta VK, Singh S, Agrawal A, Siddiqi NJ, Sharma B. Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals. Biochem Res Int. 2015;2015:534769.
- Lakshmi BV, Sudhakar M, Aparna M. Protective potential of Black grapes against lead induced oxidative stress in rats. Environ Toxicol Pharmacol. 2013 May;35(3):361-8.
- Winiarska-Mieczan A. The potential protective effect of green, black, red and white tea infusions against adverse effect of cadmium and lead during chronic exposure - A rat model study. Regul Toxicol Pharmacol. 2015 Nov;73(2):521-9.
- Mabrouk A, Ben Cheikh H. Thymoquinone supplementation reverses lead-induced oxidative stress in adult rat testes. Gen Physiol Biophys. 2015 Jan;34(1):65-72.
- Chandrasekaran VR, Hsu DZ, Liu MY. Beneficial effect of sesame oil on heavy metal toxicity. JPEN J Parenter Enteral Nutr. 2014 Feb;38(2):179-85.
- Nwokocha CR, Nwokocha MI, Aneto I, Obi J, Udekweleze DC, Olatunde B, Owu DU, Iwuala MO. Comparative analysis on the effect of Lycopersicon esculentum (tomato) in reducing cadmium, mercury and lead accumulation in liver. Food Chem Toxicol. 2012 Jun;50(6):2070-3.
- Sharma V, Kansal L, Sharma A. Prophylactic efficacy of Coriandrum sativum (Coriander) on testis of lead-exposed mice. Biol Trace Elem Res. 2010 Sep;136(3):337-54.
- Velaga MK, Daughtry LK, Jones AC, Yallapragada PR, Rajanna S, Rajanna B. Attenuation of lead-induced oxidative stress in rat brain, liver, kidney and blood of male Wistar rats by Moringa oleifera seed powder. J Environ Pathol Toxicol Oncol. 2014;33(4):323-37.
- Abdel Moneim AE, Dkhil MA, Al-Quraishy S. Effects of flaxseed oil on lead acetate-induced neurotoxicity in rats. Biol Trace Elem Res. 2011 Dec;144(1-3):904-13.
- O'Connor ME, Rich D. Children with moderately elevated lead levels: is chelation with DMSA helpful? Clin Pediatr (Phila). 1999 Jun;38(6):325-31.
- Henretig F. Lead poisoning prevention, not chelation (commentary). J Toxicol Clin Toxicol. 2001;39(7):659-60.
- Rosen JF, Mushak P. Primary prevention of childhood lead poisoning--the only solution. N Engl J Med. 2001 May 10;344(19):1470-1.
- McKay CA Jr. Role of chelation in the treatment of lead poisoning: discussion of the Treatment of Lead-Exposed Children Trial (TLC). J Med Toxicol. 2013 Dec;9(4):339-43.
- Rogan WJ, Dietrich KN, Ware JH, Dockery DW, Salganik M, Radcliffe J, Jones RL, Ragan NB, Chisolm JJ Jr, Rhoads GG; Treatment of Lead-Exposed Children Trial Group. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med. 2001 May 10;344(19):1421-6.
- [No authors listed] Effect of lactose on intestinal absorption of lead. Nutr Rev. 1982 Apr;40(4):116-7.
- Ballew C, Bowman B. Recommending calcium to reduce lead toxicity in children: a critical review. Nutr Rev. 2001 Mar;59(3 Pt 1):71-9.
- Queiroz ML, da Rocha MC, Torello CO, de Souza Queiroz J, Bincoletto C, Morgano MA, Romano MR, Paredes-Gamero EJ, Barbosa CM, Calgarotto AK. Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice. Food Chem Toxicol. 2011 Nov;49(11):2934-41.
- Suresh Kumar K, Dahms HU, Won EJ, Lee JS, Shin KH. Microalgae - A promising tool for heavy metal remediation. Ecotoxicol Environ Saf. 2015 Mar;113:329-52.
- Ahamed M, Siddiqui MK. Environmental lead toxicity and nutritional factors. Clin Nutr. 2007 Aug;26(4):400-8. Epub 2007 May 17.
- Hu H, Kotha S, Brennan T. The role of nutrition in mitigating environmental insults: policy and ethical issues. Environ Health Perspect. 1995 Sep;103 Suppl 6:185-90.
- Markowitz ME, Sinnett M, Rosen JF. A randomized trial of calcium supplementation for childhood lead poisoning. Pediatrics. 2004 Jan;113(1 Pt 1):e34-9.
- Olusola BO, Aransiola MN. Biosorption of Lead (Pb2+) from Industrial Effluent using Green Algae. International Journal of Science and Research (IJSR) ISSN (Online): 2319-7064.
- Aung WL, Hlaing NN, Aye KN. Biosorption of Lead (Pb2+) by using Chlorella vulgaris. International Journal of Chemical, Environmental & Biological Sciences (IJCEBS) Volume 1, Issue 2 (2013) ISSN 2320 –4087 (Online).
- Cobbett CS. Phytochelatins and their roles in heavy metal detoxification. Plant Physiol. 2000 Jul;123(3):825-32.
- Mustafa HN. Potential Alleviation of Chlorella vulgaris and Zingiber officinale on Lead-Induced Testicular Toxicity: an Ultrastructural Study. Folia Biol (Krakow). 2015;63(4):269-78.
- Hugelmeyer CD, Moorhead JC, Horenblas L, Bayer MJ. Fatal lead encephalopathy following foreign body ingestion: case report. J Emerg Med. 1988;6(5):397-400.
Icons created by Francisca Arévalo, Nikita Kozin, Symbolon, and Evan MacDonald from the Noun Project.
Image credit: S. Alexis via Flickr. Image has been modified.
Motion graphics by Avocado Video.
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Best Foods for Lead Poisoning: Chlorella, Cilantro, Tomatoes, Moringa?
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Content URLDoctor's Note
Isn’t that frustrating? Why don’t they just try out foods on people? There are some human studies—promising human studies. Check out Best Food for Lead Poisoning: Garlic and Can Vitamin C Help with Lead Poisoning?.
For even more videos on lead, see:
- Lead in Drinking Water
- How the Leaded Gas Industry Got Away with It
- How the Lead Paint Industry Got Away with It
- “Normal” Blood Lead Levels Can Be Toxic
- The Effects of Low-Level Lead Exposure in Adults
- How to Lower Lead Levels with Diet: Thiamine, Fiber, Iron, Fat, Fasting?
- How to Lower Lead Levels with Diet: Breakfast, Whole Grains, Milk, Tofu?
- Yellow Bell Peppers for Male Infertility and Lead Poisoning?
- Is Lipstick Safe Given the Lead Contamination?
- Can Saunas Detoxify Lead from the Body?
- How to Lower Heavy Metals Levels with Diet
- How Much Lead Is in Organic Chicken Soup (Bone Broth)?
- Lead in Calcium Supplements
- Should Pregnant Women Take Calcium Supplements to Lower Lead Levels?
- Lead Contamination in Fish and Game
- Lead Contamination in Hot Sauces
To learn more about chlorella, see:
- Preserving Athlete Immunity with Chlorella
- Treating Hepatitis C with Chlorella
- Detoxifying with Chlorella
UPDATE: Some chlorella supplements have been found to contain unacceptable levels of contamination with toxin-producing species of algae, so I would recommend against consuming it. Video forthcoming…
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