How many months does it take to clear 99% of the mercury and other industrial toxins from one’s body, and what role might our fat stores play in holding on to fat-soluble pollutants?
How Long to Detox from Fish Before Pregnancy?
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
“[I]ncreased fish consumption of mothers before and during pregnancy leads to increased [exposure to both mercury and the long-chain omega 3 DHA].” Mercury “may negatively affect…brain development [in one’s unborn baby], whereas DHA may…stimulate brain development.” As we saw, though, the results of this study showed that the negative effect of mercury outweighs the beneficial effect of DHA for most species of fish. Unfortunately, in the last two national surveys of “women of childbearing age, [they] were less aware and knowledgeable about this [problem] than other women,” despite FDA and EPA campaigns to inform every OB/GYN and pediatrician in the United States about the potential risks of mercury in fish. But I wanted to highlight the “before.” Not just during pregnancy, but even before one gets pregnant.
Since mercury sticks around, women may want to “avoid polluted fish consumption” for a year before they get pregnant, in addition to just during pregnancy. The reason they suggest a year before getting pregnant is because the half-life of mercury in the body is estimated to be about two months. They fed folks two servings a week of tuna, and other high-mercury fish, to push their mercury levels up, and then stopped the fish at week 14. And, slowly but surely, their levels came back down. I know a lot of moms are concerned about exposing their children to mercury-containing vaccines, but if they just ate a single serving a week, or less, of fish during pregnancy, the latest data shows their infants end up with substantially more mercury in their bodies than getting injected with up to six mercury-containing vaccines.
But, with a two-month half-life, within a year of stopping fish consumption, your body can detox nearly 99% of the mercury. Unfortunately, the other industrial pollutants in fish can take longer for our body to get rid of—a half life as long as ten years for certain dioxins, and PBCs, and DDT metabolites found in fish. So, to get that same 99% drop could take 120 years, which is a long time to delay one’s first child.
What do these other pollutants do? Well, high concentrations of industrial contaminants are associated with 38 times the odds of diabetes. That’s as strong as the relationship between smoking and lung cancer! Isn’t diabetes mostly about obesity, though? Well, these are fat-soluble pollutants, and so, “[a]s people get fatter, the retention and toxicity of [persistent organic pollutants] related to the risk of diabetes may increase,” suggesting the “shocking” possibility that “obesity [may only be] a vehicle for such chemicals.” We may be storing pollutants in our spare tire, like a hazardous waste dump.
Now, the pollutants could just be a marker of animal product consumption. Maybe that’s why there’s such higher diabetes risk, since more than 90% of the persistent organic pollutants comes from animal foods—unless you work in a chemical factory, or stumble across some toxic waste. And, indeed, in the U.S., every serving of fish a week is associated with a 5% increased risk of diabetes—which makes fish consumption about 80% worse than red meat.
Please consider volunteering to help out on the site.
- S. J. Petre, D. K. Sackett, D. D. Aday. Do national advisories serve local consumers: An assessment of mercury in economically important North Carolina fish. J. Environ. Monit. 2012 14(5):1410 - 1416.
- P. Grandjean, J. E. Henriksen, A. L. Choi, M. S. Petersen, C. Dalgaard, F. Nielsen, P. Weihe. Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes. Epidemiology. 2011 22(3):410 - 417.
- D.-H. Lee, I.-K. Lee, K. Song, M. Steffes, W. Toscano, B. A. Baker, D. R. Jacobs Jr. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: Results from the National Health and Examination Survey 1999-2002. Diabetes Care 2006 29(7):1638 - 1644.
- A. Wallin, D. Di Giuseppe, N. Orsini, P. S. Patel, N. G. Forouhi, A. Wolk. Fish consumption, dietary long-chain n-3 fatty acids, and risk of type 2 diabetes: Systematic review and meta-analysis of prospective studies. Diabetes Care. 2012 35(4):918 - 929.
- R. F. White, C. L. Palumbo, D. A. Yurgelun-Todd, K. J. Heaton, P. Weihe, F. Debes, P. Grandjean. Functional MRI approach to developmental methylmercury and polychlorinated biphenyl neurotoxicity. Neurotoxicology. 2011 32(6):975 - 980.
- M. J. Zeilmaker, J. Hoekstra, J. C. H. van Eijkeren, N. de Jong, A. Hart, M. Kennedy, H. Owen, H. Gunnlaugsdottir. Fish consumption during child bearing age: A quantitative risk-benefit analysis on neurodevelopment. Food Chem. Toxicol. 2013 54(NA):30 - 34.
- D. A. Axelrad, D. C. Bellinger, L. M. Ryan, T. J. Woodruff. Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data. Environ. Health Perspect. 2007 115(4):609 - 615.
- E. Oken, A. L. Choi, M. R. Karagas, K. Mariën, C. M. Rheinberger, R. Schoeny, E. Sunderland, S. Korrick. Which fish should I eat? Perspectives influencing fish consumption choices. Environ. Health Perspect. 2012 120(6):790 - 798.
- J. Julvez, F. Debes, P. Weihe, A. Choi, P. Grandjean. Sensitivity of continuous performance test (CPT) at age 14 years to developmental methylmercury exposure. Neurotoxicol Teratol. 2010 32(6):627 - 632.
- J. G. Dórea, V. L. V. A. Bezerra, V. Fajon, M. Horvat. Speciation of methyl- and ethyl-mercury in hair of breastfed infants acutely exposed to thimerosal-containing vaccines. Clin. Chim. Acta. 2011 412(17 - 18):1563 - 1566.
- P. Grandjean, E. Budtz-Jorgensen, D. B. Barr, L. L. Needham, P. Weihe, B. Heinzow. Elimination half-lives of polychlorinated biphenyl congeners in children. Environ. Sci. Technol. 2008 42(18):6991 - 6996.
- I. B. Cace, A. Milardovic, I. Prpic, R. Krajina, O. Petrovic, P. Vukelic, Z. Spiric, M. Horvat, D. Mazej, J. Snoj. Relationship between the prenatal exposure to low-level of mercury and the size of a newborn's cerebellum. Med. Hypotheses. 2011 76(4):514 - 516.
- M. R. Karagas, A. L. Choi, E. Oken, M. Horvat, R. Schoeny, E. Kamai, W. Cowell, P. Grandjean, S. Korrick. Evidence on the human health effects of low-level methylmercury exposure. Environ. Health Perspect. 2012 120(6):799 - 806.
- J. J. Strain, P. W. Davidson, M. P. Bonham, E. M. Duffy, A. Stokes-Riner, S. W. Thurston, J. M. W. Wallace, P. J. Robson, C. F. Shamlaye, L. A. Georger, J. Sloane-Reeves, E. Cernichiari, R. L. Canfield, C. Cox, L. S. Huang, J. Janciuras, G. J. Myers, T. W. Clarkson. Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study. Neurotoxicology 2008 29(5):776 - 782.
- A. M. Lando, Y. Zhang. Awareness and knowledge of methylmercury in fish in the United States. Environ. Res. 2011 111(3):442 - 450.
- P. A. Olsvik, H. Amlund, B. E. Torstensen. Dietary lipids modulate methylmercury toxicity in Atlantic salmon. Food Chem. Toxicol. 2011 49(12):3258 - 3271.
- K. Yaginuma-Sakurai, K. Murata, M. Iwai-Shimada, K. Nakai, N. Kurokawa, N. Tatsuta, H. Satoh. Hair-to-blood ratio and biological half-life of mercury: Experimental study of methylmercury exposure through fish consumption in humans. J Toxicol Sci. 2012 37(1):123 - 130.
- S. D. Stellman, T. Takezaki, L. Wang, Y. Chen, M. L. Citron, M. V. Djordjevic, S. Harlap, J. E. Muscat, A. I. Neugut, E. L. Wynder, H. Ogawa, K. Tajima, K. Aoki. Smoking and lung cancer risk in American and Japanese men: An international case-control study. Cancer Epidemiol. Biomarkers Prev. 2001 10(11):1193 - 1199.
- M. Porta. Persistent organic pollutants and the burden of diabetes. Lancet. 2006 368(9535):558-559.
- L. Trasande, Y. Liu. Reducing the staggering costs of environmental disease in children, estimated at $76.6 Billion in 2008. Health Aff (Millwood) 2011 30(5):863 - 870.
- D. McAlpine, S. Araki. Minamata disease: An unusual neurological disorder caused by contaminated fish. Lancet 1958 2(7047):629 - 631.
- S. B. Elhassani. The many faces of methylmercury poisoning. J. Toxicol., Clin. Toxicol. 1982 19(8):875 - 906.
- B. H. Choi, L. W. Lapham, L. Amin-Zaki, T. Saleem. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: A major effect of methylmercury poisoning in utero. J. Neuropathol. Exp. Neurol. 1978 37(6):719 - 733.
- P. C. Dagnelie, W. A. van Staveren, A. H. Roos, L. G. Tuinstra, J. Burema. Nutrients and contaminants in human milk from mothers on macrobiotic and omnivorous diets. Eur J Clin Nutr. 1992 46(5):355 - 366.
Images thanks to harinaivoteza via flickr. Thanks to Ellen Reid for her image-finding expertise, and Jeff Thomas for his Keynote help.
- abdominal fat
- animal products
- beef
- body fat
- brain health
- children
- cognition
- detoxification
- DHA
- diabetes
- dioxins
- fat
- FDA
- fish
- industrial pollutants
- infants
- meat
- mercury
- obesity
- omega-3 fatty acids
- PCBs
- persistent organic pollutants
- prediabetes
- pregnancy
- red meat
- reproductive health
- seafood
- tuna
- vaccines
- weight loss
- women's health
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
“[I]ncreased fish consumption of mothers before and during pregnancy leads to increased [exposure to both mercury and the long-chain omega 3 DHA].” Mercury “may negatively affect…brain development [in one’s unborn baby], whereas DHA may…stimulate brain development.” As we saw, though, the results of this study showed that the negative effect of mercury outweighs the beneficial effect of DHA for most species of fish. Unfortunately, in the last two national surveys of “women of childbearing age, [they] were less aware and knowledgeable about this [problem] than other women,” despite FDA and EPA campaigns to inform every OB/GYN and pediatrician in the United States about the potential risks of mercury in fish. But I wanted to highlight the “before.” Not just during pregnancy, but even before one gets pregnant.
Since mercury sticks around, women may want to “avoid polluted fish consumption” for a year before they get pregnant, in addition to just during pregnancy. The reason they suggest a year before getting pregnant is because the half-life of mercury in the body is estimated to be about two months. They fed folks two servings a week of tuna, and other high-mercury fish, to push their mercury levels up, and then stopped the fish at week 14. And, slowly but surely, their levels came back down. I know a lot of moms are concerned about exposing their children to mercury-containing vaccines, but if they just ate a single serving a week, or less, of fish during pregnancy, the latest data shows their infants end up with substantially more mercury in their bodies than getting injected with up to six mercury-containing vaccines.
But, with a two-month half-life, within a year of stopping fish consumption, your body can detox nearly 99% of the mercury. Unfortunately, the other industrial pollutants in fish can take longer for our body to get rid of—a half life as long as ten years for certain dioxins, and PBCs, and DDT metabolites found in fish. So, to get that same 99% drop could take 120 years, which is a long time to delay one’s first child.
What do these other pollutants do? Well, high concentrations of industrial contaminants are associated with 38 times the odds of diabetes. That’s as strong as the relationship between smoking and lung cancer! Isn’t diabetes mostly about obesity, though? Well, these are fat-soluble pollutants, and so, “[a]s people get fatter, the retention and toxicity of [persistent organic pollutants] related to the risk of diabetes may increase,” suggesting the “shocking” possibility that “obesity [may only be] a vehicle for such chemicals.” We may be storing pollutants in our spare tire, like a hazardous waste dump.
Now, the pollutants could just be a marker of animal product consumption. Maybe that’s why there’s such higher diabetes risk, since more than 90% of the persistent organic pollutants comes from animal foods—unless you work in a chemical factory, or stumble across some toxic waste. And, indeed, in the U.S., every serving of fish a week is associated with a 5% increased risk of diabetes—which makes fish consumption about 80% worse than red meat.
Please consider volunteering to help out on the site.
- S. J. Petre, D. K. Sackett, D. D. Aday. Do national advisories serve local consumers: An assessment of mercury in economically important North Carolina fish. J. Environ. Monit. 2012 14(5):1410 - 1416.
- P. Grandjean, J. E. Henriksen, A. L. Choi, M. S. Petersen, C. Dalgaard, F. Nielsen, P. Weihe. Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes. Epidemiology. 2011 22(3):410 - 417.
- D.-H. Lee, I.-K. Lee, K. Song, M. Steffes, W. Toscano, B. A. Baker, D. R. Jacobs Jr. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: Results from the National Health and Examination Survey 1999-2002. Diabetes Care 2006 29(7):1638 - 1644.
- A. Wallin, D. Di Giuseppe, N. Orsini, P. S. Patel, N. G. Forouhi, A. Wolk. Fish consumption, dietary long-chain n-3 fatty acids, and risk of type 2 diabetes: Systematic review and meta-analysis of prospective studies. Diabetes Care. 2012 35(4):918 - 929.
- R. F. White, C. L. Palumbo, D. A. Yurgelun-Todd, K. J. Heaton, P. Weihe, F. Debes, P. Grandjean. Functional MRI approach to developmental methylmercury and polychlorinated biphenyl neurotoxicity. Neurotoxicology. 2011 32(6):975 - 980.
- M. J. Zeilmaker, J. Hoekstra, J. C. H. van Eijkeren, N. de Jong, A. Hart, M. Kennedy, H. Owen, H. Gunnlaugsdottir. Fish consumption during child bearing age: A quantitative risk-benefit analysis on neurodevelopment. Food Chem. Toxicol. 2013 54(NA):30 - 34.
- D. A. Axelrad, D. C. Bellinger, L. M. Ryan, T. J. Woodruff. Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data. Environ. Health Perspect. 2007 115(4):609 - 615.
- E. Oken, A. L. Choi, M. R. Karagas, K. Mariën, C. M. Rheinberger, R. Schoeny, E. Sunderland, S. Korrick. Which fish should I eat? Perspectives influencing fish consumption choices. Environ. Health Perspect. 2012 120(6):790 - 798.
- J. Julvez, F. Debes, P. Weihe, A. Choi, P. Grandjean. Sensitivity of continuous performance test (CPT) at age 14 years to developmental methylmercury exposure. Neurotoxicol Teratol. 2010 32(6):627 - 632.
- J. G. Dórea, V. L. V. A. Bezerra, V. Fajon, M. Horvat. Speciation of methyl- and ethyl-mercury in hair of breastfed infants acutely exposed to thimerosal-containing vaccines. Clin. Chim. Acta. 2011 412(17 - 18):1563 - 1566.
- P. Grandjean, E. Budtz-Jorgensen, D. B. Barr, L. L. Needham, P. Weihe, B. Heinzow. Elimination half-lives of polychlorinated biphenyl congeners in children. Environ. Sci. Technol. 2008 42(18):6991 - 6996.
- I. B. Cace, A. Milardovic, I. Prpic, R. Krajina, O. Petrovic, P. Vukelic, Z. Spiric, M. Horvat, D. Mazej, J. Snoj. Relationship between the prenatal exposure to low-level of mercury and the size of a newborn's cerebellum. Med. Hypotheses. 2011 76(4):514 - 516.
- M. R. Karagas, A. L. Choi, E. Oken, M. Horvat, R. Schoeny, E. Kamai, W. Cowell, P. Grandjean, S. Korrick. Evidence on the human health effects of low-level methylmercury exposure. Environ. Health Perspect. 2012 120(6):799 - 806.
- J. J. Strain, P. W. Davidson, M. P. Bonham, E. M. Duffy, A. Stokes-Riner, S. W. Thurston, J. M. W. Wallace, P. J. Robson, C. F. Shamlaye, L. A. Georger, J. Sloane-Reeves, E. Cernichiari, R. L. Canfield, C. Cox, L. S. Huang, J. Janciuras, G. J. Myers, T. W. Clarkson. Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study. Neurotoxicology 2008 29(5):776 - 782.
- A. M. Lando, Y. Zhang. Awareness and knowledge of methylmercury in fish in the United States. Environ. Res. 2011 111(3):442 - 450.
- P. A. Olsvik, H. Amlund, B. E. Torstensen. Dietary lipids modulate methylmercury toxicity in Atlantic salmon. Food Chem. Toxicol. 2011 49(12):3258 - 3271.
- K. Yaginuma-Sakurai, K. Murata, M. Iwai-Shimada, K. Nakai, N. Kurokawa, N. Tatsuta, H. Satoh. Hair-to-blood ratio and biological half-life of mercury: Experimental study of methylmercury exposure through fish consumption in humans. J Toxicol Sci. 2012 37(1):123 - 130.
- S. D. Stellman, T. Takezaki, L. Wang, Y. Chen, M. L. Citron, M. V. Djordjevic, S. Harlap, J. E. Muscat, A. I. Neugut, E. L. Wynder, H. Ogawa, K. Tajima, K. Aoki. Smoking and lung cancer risk in American and Japanese men: An international case-control study. Cancer Epidemiol. Biomarkers Prev. 2001 10(11):1193 - 1199.
- M. Porta. Persistent organic pollutants and the burden of diabetes. Lancet. 2006 368(9535):558-559.
- L. Trasande, Y. Liu. Reducing the staggering costs of environmental disease in children, estimated at $76.6 Billion in 2008. Health Aff (Millwood) 2011 30(5):863 - 870.
- D. McAlpine, S. Araki. Minamata disease: An unusual neurological disorder caused by contaminated fish. Lancet 1958 2(7047):629 - 631.
- S. B. Elhassani. The many faces of methylmercury poisoning. J. Toxicol., Clin. Toxicol. 1982 19(8):875 - 906.
- B. H. Choi, L. W. Lapham, L. Amin-Zaki, T. Saleem. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: A major effect of methylmercury poisoning in utero. J. Neuropathol. Exp. Neurol. 1978 37(6):719 - 733.
- P. C. Dagnelie, W. A. van Staveren, A. H. Roos, L. G. Tuinstra, J. Burema. Nutrients and contaminants in human milk from mothers on macrobiotic and omnivorous diets. Eur J Clin Nutr. 1992 46(5):355 - 366.
Images thanks to harinaivoteza via flickr. Thanks to Ellen Reid for her image-finding expertise, and Jeff Thomas for his Keynote help.
- abdominal fat
- animal products
- beef
- body fat
- brain health
- children
- cognition
- detoxification
- DHA
- diabetes
- dioxins
- fat
- FDA
- fish
- industrial pollutants
- infants
- meat
- mercury
- obesity
- omega-3 fatty acids
- PCBs
- persistent organic pollutants
- prediabetes
- pregnancy
- red meat
- reproductive health
- seafood
- tuna
- vaccines
- weight loss
- women's health
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How Long to Detox from Fish Before Pregnancy?
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Content URLDoctor's Note
Mercury vs. Omega-3s for Brain Development is the study about balancing risks and benefits.
Update: In 2019, I did a new video on fish and pregnancy: Avoiding Fish for 5 Years Before Pregnancy.
I explored how long it takes to get rid of some of the other pollutants in How Fast Can Children Detoxify from PCBs? PCBs are found most concentrated in fish and eggs (see Food Sources of PCB Chemical Pollutants). This may also help explain the remarkable findings in Eggs & Diabetes.
The fact that we can still find DDT in Umbilical Cord Blood decades after the pesticide was banned speaks to the persistence of some pollutants. There’s a shortcut for moms, but it’s The Wrong Way to Detox.
More on the risks of mercury can be found in these videos:
- Fish Consumption Associated with Brain Shrinkage
- Hair Testing for Mercury before Considering Pregnancy
- The Effect of Canned Tuna on Future Wages
- Nerves of Mercury
For more context, check out my associated blog post: Top 10 Most Popular Videos from 2013.
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