How might we reduce the risk of premature death from dairy consumption?
Why Do Milk Drinkers Live Shorter Lives on Average?
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
In my video on milk and bones, I discussed this set of studies, following 100,000 people for up to two decades, finding a 60 percent higher risk of hip fracture among women who drank a lot of milk. The researchers suggested it might be due to the galactose, which is a breakdown product of the milk sugar lactose, based on the fact that people with high levels in their blood––because they were born with an inability to detoxify the stuff––can end up with weakened bones. But that’s not all galactose can do.
Galactose is what scientists use to cause accelerated aging in lab animals, since it’s so successful at mimicking aging by inducing degenerative changes in the brain, heart, lungs, liver, kidney, etc. “The life-shortened animals showed neurodegeneration, mental retardation and cognitive dysfunction, … diminished immune responses, and a reduction of reproductive ability.” And it doesn’t take much—just the human equivalent of one to two glasses’ worth of milk a day.
However, humans aren’t rodents. For example, we’ve known for nearly a century that you can cause cataracts in rats by feeding them a lot of lactose or galactose, but the epidemiological data is mixed as to whether dairy is doing the same in people.
The Swedish studies didn’t just look at bone, though, but milk and mortality. More milk was associated with more death. In women, three glasses of milk a day was associated with nearly twice the risk of dying prematurely. The medical journal editorial accompanying the study emphasized that, given the rise in milk consumption around the world, “the role of milk in mortality needs to be established definitively now.”
With the then-largest-ever study on milk intake and mortality suggesting such adverse effects, Harvard researchers stepped in with three of their cohorts to form a study twice as big to see if the earlier findings were just a fluke. Following more than 200,000 men and women for up to three decades, they confirmed the bad news. Those who consumed more dairy lived significantly shorter lives. Every half serving more of regular milk a day was associated with 9 percent increased risk of dying from cardiovascular disease, 11 percent increased risk of dying from cancer, and an 11 percent increased risk of dying from all causes put together. This is all the more remarkable since milk drinking is typically associated with healthier habits, like more exercise and less smoking and drinking, though they did try to control for all these factors.
Of course, it does matter what you eat instead. This Harvard analysis, published in the New England Journal of Medicine, found that swapping dairy for meat, red meat, poultry, or fish would not be expected to do your body any favors, and you would be expected to live longer eating dairy than eggs or processed meat. It’s only when you swap dairy for plant-based sources of protein did they find a significant drop in mortality risk.
When all of the milk and mortality studies are put together, it appears the excess mortality risk is limited to regular as opposed to low-fat (like skim) milk. This suggests it may be more of a saturated fat issue, though that doesn’t explain why soured (or fermented) milk appears to have the opposite impact. So, maybe it’s both the butterfat and the galactose. A randomized crossover study of low-fat dairy, fermented dairy, and unfermented dairy found that study subjects had significantly higher IL-6 inflammation levels during unfermented regular dairy weeks, compared to when they were switched to either the fermented or low-fat dairy products. The fermentation process can eliminate some of the galactose.
As we age, our ability to detoxify galactose declines by as much as 40 percent, which would make it even more important to avoid dairy later in life––if indeed galactose is the culprit. But if galactose does its dirty work through oxidation and inflammation, might increased fruit and vegetable intake help mediate some of the harm? In animals, galactose-induced aging can be slowed by fruit and vegetable consumption. For example, feeding rats blueberries can decrease the brain damage induced by the milk sugar. Might it be able to help with the higher levels of oxidative stress and inflammation found among human milk-drinkers? Unfortunately, women drinking three or more glasses of milk a day had more than twice the risk of hip fractures compared to women drinking less than a glass a day, regardless of whether they were eating more or less fruits and vegetables. But those high milk consumers consuming five or more servings of fruits and vegetables a day did reduce their chance of dying prematurely to just 60 percent greater than those drinking less milk; so, antioxidant-rich foods may be able to modify the elevated death rate associated with high milk consumption.
Highly influential advocacy organizations such as the U.S. National Osteoporosis Foundation or the Europe-based International Osteoporosis Foundation continue to push dairy, drugs, and calcium supplements, despite the countervailing evidence that I’ve reviewed. Why do they keep pushing dairy, drugs, and supplements? Perhaps because their objectivity is compromised by the influence of their commercial sponsors that include companies that market—you guessed it—dairy, drugs, and supplements. Most recent reviews on dairy and osteoporosis in the English-language medical literature were found to be written by those with ties to the dairy industry. The primary justification for inclusion of dairy in federal nutrition recommendations is based on purported bone benefits that are not supported by the available evidence.
What if dietary guidelines were fashioned without commercial influence? In 2019, Canada decided to exclude industry reports and stick to the science in the formation of their new dietary guidelines. What a concept! Major changes included a new emphasis on plant-based food intake, limiting junk, and the removal of the dairy food group.
Please consider volunteering to help out on the site.
- Michaëlsson K, Wolk A, Langenskiöld S, et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. BMJ. 2014;349:g6015.
- van Erven B, Römers MMM, Rubio-Gozalbo ME. Revised proposal for the prevention of low bone mass in patients with classic galactosemia. JIMD Rep. 2014;17:41-46.
- Azman KF, Zakaria R. D-Galactose-induced accelerated aging model: an overview. Biogerontology. 2019;20(6):763-782.
- Cui X, Wang L, Zuo P, et al. D-galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress. Biogerontology. 2004;5(5):317-325.
- Simoons FJ. A geographic approach to senile cataracts: possible links with milk consumption, lactase activity, and galactose metabolism. Dig Dis Sci. 1982;27(3):257-264.
- Mustafa OM, Daoud YJ. Is dietary milk intake associated with cataract extraction history in older adults? An analysis from the us population. J Ophthalmol. 2020;2020:2562875.
- Schooling CM. Milk and mortality. BMJ. 2014;349:g6205.
- Ding M, Li J, Qi L, et al. Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies. BMJ. 2019;367:l6204.
- Fardellone P, Séjourné A, Blain H, Cortet B, Thomas T, GRIO Scientific Committee. Osteoporosis: Is milk a kindness or a curse? Joint Bone Spine. 2017;84(3):275-281.
- Willett WC, Ludwig DS. Milk and health. N Engl J Med. 2020;382(7):644-654.
- Naghshi S, Sadeghi O, Larijani B, Esmaillzadeh A. High vs. low-fat dairy and milk differently affects the risk of all-cause, CVD, and cancer death: A systematic review and dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2022;62(13):3598-3612.
- Tognon G, Nilsson LM, Shungin D, et al. Nonfermented milk and other dairy products: associations with all-cause mortality. Am J Clin Nutr. 2017;105(6):1502-1511.
- Nestel PJ, Mellett N, Pally S, et al. Effects of low-fat or full-fat fermented and non-fermented dairy foods on selected cardiovascular biomarkers in overweight adults. Br J Nutr. 2013;110(12):2242-2249.
- Marchesini G, Bua V, Brunori A, et al. Galactose elimination capacity and liver volume in aging man. Hepatology. 1988;8(5):1079-1083.
- Michaëlsson K, Byberg L. Interpretation of milk research results. Osteoporos Int. 2018;29(3):773-775.
- Çoban J, Doğan-Ekici I, Aydın AF, Betül-Kalaz E, Doğru-Abbasoğlu S, Uysal M. Blueberry treatment decreased D-galactose-induced oxidative stress and brain damage in rats. Metab Brain Dis. 2015;30(3):793-802.
- Michaëlsson K, Wolk A, Langenskiöld S, et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. BMJ. 2014;349:g6015.
- Michaëlsson K, Wolk A, Lemming EW, Melhus H, Byberg L. Intake of milk or fermented milk combined with fruit and vegetable consumption in relation to hip fracture rates: a cohort study of Swedish women. J Bone Miner Res. 2018;33(3):449-457.
- Michaëlsson K, Wolk A, Melhus H, Byberg L. Milk, fruit and vegetable, and total antioxidant intakes in relation to mortality rates: cohort studies in women and men. Am J Epidemiol. 2017;185(5):345-361.
- Grey A, Bolland M. Web of industry, advocacy, and academia in the management of osteoporosis. BMJ. 2015;351:h3170.
- Byberg L, Warensjö Lemming E. Milk consumption for the prevention of fragility fractures. Nutrients. 2020;12(9):2720.
- Dai Z, Kroeger CM, Lawrence M, Scrinis G, Bero L. Comparison of methodological quality between the 2007 and 2019 Canadian dietary guidelines. Public Health Nutr. 2020;23(16):2879-2885.
Motion graphics by Avo Media
- aging
- animal products
- animal protein
- animal studies
- beverages
- bone health
- bone mineral density
- cardiovascular disease
- cardiovascular health
- dairy
- dietary guidelines
- fruit
- galactose
- Harvard
- heart disease
- industry influence
- inflammation
- lactose
- lifespan
- longevity
- meat
- milk
- mortality
- osteoporosis
- plant protein
- saturated fat
- vegetables
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
In my video on milk and bones, I discussed this set of studies, following 100,000 people for up to two decades, finding a 60 percent higher risk of hip fracture among women who drank a lot of milk. The researchers suggested it might be due to the galactose, which is a breakdown product of the milk sugar lactose, based on the fact that people with high levels in their blood––because they were born with an inability to detoxify the stuff––can end up with weakened bones. But that’s not all galactose can do.
Galactose is what scientists use to cause accelerated aging in lab animals, since it’s so successful at mimicking aging by inducing degenerative changes in the brain, heart, lungs, liver, kidney, etc. “The life-shortened animals showed neurodegeneration, mental retardation and cognitive dysfunction, … diminished immune responses, and a reduction of reproductive ability.” And it doesn’t take much—just the human equivalent of one to two glasses’ worth of milk a day.
However, humans aren’t rodents. For example, we’ve known for nearly a century that you can cause cataracts in rats by feeding them a lot of lactose or galactose, but the epidemiological data is mixed as to whether dairy is doing the same in people.
The Swedish studies didn’t just look at bone, though, but milk and mortality. More milk was associated with more death. In women, three glasses of milk a day was associated with nearly twice the risk of dying prematurely. The medical journal editorial accompanying the study emphasized that, given the rise in milk consumption around the world, “the role of milk in mortality needs to be established definitively now.”
With the then-largest-ever study on milk intake and mortality suggesting such adverse effects, Harvard researchers stepped in with three of their cohorts to form a study twice as big to see if the earlier findings were just a fluke. Following more than 200,000 men and women for up to three decades, they confirmed the bad news. Those who consumed more dairy lived significantly shorter lives. Every half serving more of regular milk a day was associated with 9 percent increased risk of dying from cardiovascular disease, 11 percent increased risk of dying from cancer, and an 11 percent increased risk of dying from all causes put together. This is all the more remarkable since milk drinking is typically associated with healthier habits, like more exercise and less smoking and drinking, though they did try to control for all these factors.
Of course, it does matter what you eat instead. This Harvard analysis, published in the New England Journal of Medicine, found that swapping dairy for meat, red meat, poultry, or fish would not be expected to do your body any favors, and you would be expected to live longer eating dairy than eggs or processed meat. It’s only when you swap dairy for plant-based sources of protein did they find a significant drop in mortality risk.
When all of the milk and mortality studies are put together, it appears the excess mortality risk is limited to regular as opposed to low-fat (like skim) milk. This suggests it may be more of a saturated fat issue, though that doesn’t explain why soured (or fermented) milk appears to have the opposite impact. So, maybe it’s both the butterfat and the galactose. A randomized crossover study of low-fat dairy, fermented dairy, and unfermented dairy found that study subjects had significantly higher IL-6 inflammation levels during unfermented regular dairy weeks, compared to when they were switched to either the fermented or low-fat dairy products. The fermentation process can eliminate some of the galactose.
As we age, our ability to detoxify galactose declines by as much as 40 percent, which would make it even more important to avoid dairy later in life––if indeed galactose is the culprit. But if galactose does its dirty work through oxidation and inflammation, might increased fruit and vegetable intake help mediate some of the harm? In animals, galactose-induced aging can be slowed by fruit and vegetable consumption. For example, feeding rats blueberries can decrease the brain damage induced by the milk sugar. Might it be able to help with the higher levels of oxidative stress and inflammation found among human milk-drinkers? Unfortunately, women drinking three or more glasses of milk a day had more than twice the risk of hip fractures compared to women drinking less than a glass a day, regardless of whether they were eating more or less fruits and vegetables. But those high milk consumers consuming five or more servings of fruits and vegetables a day did reduce their chance of dying prematurely to just 60 percent greater than those drinking less milk; so, antioxidant-rich foods may be able to modify the elevated death rate associated with high milk consumption.
Highly influential advocacy organizations such as the U.S. National Osteoporosis Foundation or the Europe-based International Osteoporosis Foundation continue to push dairy, drugs, and calcium supplements, despite the countervailing evidence that I’ve reviewed. Why do they keep pushing dairy, drugs, and supplements? Perhaps because their objectivity is compromised by the influence of their commercial sponsors that include companies that market—you guessed it—dairy, drugs, and supplements. Most recent reviews on dairy and osteoporosis in the English-language medical literature were found to be written by those with ties to the dairy industry. The primary justification for inclusion of dairy in federal nutrition recommendations is based on purported bone benefits that are not supported by the available evidence.
What if dietary guidelines were fashioned without commercial influence? In 2019, Canada decided to exclude industry reports and stick to the science in the formation of their new dietary guidelines. What a concept! Major changes included a new emphasis on plant-based food intake, limiting junk, and the removal of the dairy food group.
Please consider volunteering to help out on the site.
- Michaëlsson K, Wolk A, Langenskiöld S, et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. BMJ. 2014;349:g6015.
- van Erven B, Römers MMM, Rubio-Gozalbo ME. Revised proposal for the prevention of low bone mass in patients with classic galactosemia. JIMD Rep. 2014;17:41-46.
- Azman KF, Zakaria R. D-Galactose-induced accelerated aging model: an overview. Biogerontology. 2019;20(6):763-782.
- Cui X, Wang L, Zuo P, et al. D-galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress. Biogerontology. 2004;5(5):317-325.
- Simoons FJ. A geographic approach to senile cataracts: possible links with milk consumption, lactase activity, and galactose metabolism. Dig Dis Sci. 1982;27(3):257-264.
- Mustafa OM, Daoud YJ. Is dietary milk intake associated with cataract extraction history in older adults? An analysis from the us population. J Ophthalmol. 2020;2020:2562875.
- Schooling CM. Milk and mortality. BMJ. 2014;349:g6205.
- Ding M, Li J, Qi L, et al. Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies. BMJ. 2019;367:l6204.
- Fardellone P, Séjourné A, Blain H, Cortet B, Thomas T, GRIO Scientific Committee. Osteoporosis: Is milk a kindness or a curse? Joint Bone Spine. 2017;84(3):275-281.
- Willett WC, Ludwig DS. Milk and health. N Engl J Med. 2020;382(7):644-654.
- Naghshi S, Sadeghi O, Larijani B, Esmaillzadeh A. High vs. low-fat dairy and milk differently affects the risk of all-cause, CVD, and cancer death: A systematic review and dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2022;62(13):3598-3612.
- Tognon G, Nilsson LM, Shungin D, et al. Nonfermented milk and other dairy products: associations with all-cause mortality. Am J Clin Nutr. 2017;105(6):1502-1511.
- Nestel PJ, Mellett N, Pally S, et al. Effects of low-fat or full-fat fermented and non-fermented dairy foods on selected cardiovascular biomarkers in overweight adults. Br J Nutr. 2013;110(12):2242-2249.
- Marchesini G, Bua V, Brunori A, et al. Galactose elimination capacity and liver volume in aging man. Hepatology. 1988;8(5):1079-1083.
- Michaëlsson K, Byberg L. Interpretation of milk research results. Osteoporos Int. 2018;29(3):773-775.
- Çoban J, Doğan-Ekici I, Aydın AF, Betül-Kalaz E, Doğru-Abbasoğlu S, Uysal M. Blueberry treatment decreased D-galactose-induced oxidative stress and brain damage in rats. Metab Brain Dis. 2015;30(3):793-802.
- Michaëlsson K, Wolk A, Langenskiöld S, et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. BMJ. 2014;349:g6015.
- Michaëlsson K, Wolk A, Lemming EW, Melhus H, Byberg L. Intake of milk or fermented milk combined with fruit and vegetable consumption in relation to hip fracture rates: a cohort study of Swedish women. J Bone Miner Res. 2018;33(3):449-457.
- Michaëlsson K, Wolk A, Melhus H, Byberg L. Milk, fruit and vegetable, and total antioxidant intakes in relation to mortality rates: cohort studies in women and men. Am J Epidemiol. 2017;185(5):345-361.
- Grey A, Bolland M. Web of industry, advocacy, and academia in the management of osteoporosis. BMJ. 2015;351:h3170.
- Byberg L, Warensjö Lemming E. Milk consumption for the prevention of fragility fractures. Nutrients. 2020;12(9):2720.
- Dai Z, Kroeger CM, Lawrence M, Scrinis G, Bero L. Comparison of methodological quality between the 2007 and 2019 Canadian dietary guidelines. Public Health Nutr. 2020;23(16):2879-2885.
Motion graphics by Avo Media
- aging
- animal products
- animal protein
- animal studies
- beverages
- bone health
- bone mineral density
- cardiovascular disease
- cardiovascular health
- dairy
- dietary guidelines
- fruit
- galactose
- Harvard
- heart disease
- industry influence
- inflammation
- lactose
- lifespan
- longevity
- meat
- milk
- mortality
- osteoporosis
- plant protein
- saturated fat
- vegetables
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Why Do Milk Drinkers Live Shorter Lives on Average?
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Content URLDoctor's Note
The videos I mentioned are:
- How Well Do Medicines Like Fosamax Work to Treat Osteoporosis?
- Is Milk Good for Our Bones?
- Are Calcium Supplements Safe?
What are the Side Effects of Osteoporosis Medications Like Fosamax, Boniva, and Reclast? Check out the video.
You can also try switching to soy milk. Check out Is Soy Milk the Most Nutritious Non-Dairy Milk?.
What are Three Reasons Fruits and Vegetables May Reduce Osteoporosis Risk? What about onions and tomatoes for osteoporosis? Check out the videos.
If you haven’t yet, you can subscribe to my videos for free by clicking here. Read our important information about translations here.