Transcript: PhIP: The Three Strikes Breast Carcinogen
DNA mutation, then promoting growth, and the third strike is that PhIP then promotes invasiveness of breast cancer cells. The way breast tumors kill is by metastasis, it's got to invade surrounding tissues and organs. The way you test invasiveness is you put cells into what's called an invasion chamber where you put cancer cells on one side of a membrane with tiny pores, those little gray circles. This is the underside of the filter, showing no invasion. But add some estrogen and you can see a few cells peeking through. Add some PhIP and they really start going on the move. More invasion-promoting that straight estrogen. They conclude that “in addition to its well characterized, genotoxic potential, PhIP is potently estrogenic, is capable of powerful hormonal activity and is able to potently stimulate breast cancer cells to invade through a membrane model. This finding that PhIP is able to exert this pro-invasive appearance in breast cancer cells at such low concentrations is remarkable. The genetic toxicology of the compound coupled to its ability to enhance cell proliferation and invasion indicates that PhIP can act not only to initiate the carcinogenic process, but also to promote it." The problem is, they say, that "Exposure to PhIP is difficult to avoid because of its presence in many commonly consumed cooked meats, particularly chicken, beef and fish." But if you're able to somehow dodge those meats, and don't suck on a cigarette, tailpipe, or incinerator smokestack, maybe it's not so difficult to avoid after all.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring watch the above video. This is just an approximation of the audio contributed by Jonathan Hodgson.
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