Women with uterine fibroids should consider adding green tea to their daily diet, as a randomized, double-blind, placebo-controlled interventional trial suggests it may help as well as surgery.
The Best Food for Fibroids
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Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
What about dietary phytochemicals as a possible preventive and therapeutic option for uterine fibroids, plant based compounds with disease-preventive properties, found in whole grains, fruits, vegetables, bean, split peas, chickpeas, and lentils, herbs, spices, nuts, and certain beverages. The thought is, look, we know they can help regulate the initiation, promotion, and spread of cancerous tumors; so, what about benign tumors like fibroids? Most anti-cancer drugs on the market now, for example, were originally derived from plants or plant products; so, why not try to use plants to target the inflammation or blood supply of fibroids? Might fibroids be a consequence of chronic inflammation within the body? Well, we know that women with fibroids are more likely to eat more beef and ham, and fewer fruits and green vegetables, but whole plant foods don’t just have anti-inflammatory effects but antioxidant effects as well. When the amount of free radicals exceeds the protective effects of antioxidants, oxidative damage will occur, which has been implicated in a variety of disease states, including gynecological conditions, such as fibroids.
If you collect fresh fibroids, as well as normal uterine tissue from hysterectomy surgeries, the fibroid cells have significantly fewer antioxidant enzymes; so, might antioxidant rich foods help? Well, if you drip some strawberries in a petri dish, you can apparently kill of some fibroid tumor cells, while leaving normal uterus cells alone. But, what good does that do us. That’s only relevant if we can show those strawberry compounds get absorbed through our gut and achieve high enough concentrations in uterine tissue. The same with curcumin, the component of the spice turmeric. One of its so-called “miraculous” properties is suppressing the growth of uterine fibroid cells, but again that was just in vitro. Yes, an inhibitory effect was found, and at concentrations that don’t compromise the growth of regular uterine tissue. But, my patients are people, not petri dishes.
I mean, it’s neat to see what happens to human fibroid cells as you drip higher and higher concentrations of green tea compounds on them in a test tube, but I care less about what happens in vitro, or in mice, whether or not they have any clothes on. But there were no randomized, controlled clinical studies until, now, or at least 2013.
Subjects were randomized to green tea extract or placebo for 4 months. In the placebo group, fibroid volume increased 24%. That’s what fibroids do, they continue to grow; however, those randomized to the green tea group showed a reduction in total fibroid volume, and not just by a little, a dramatic decrease—shrunk almost a third–a highly significant difference. OK. But, did the women feel any better? Yes, a dramatic decrease in symptom severity, as well. In the placebo group, nothing much happened month after month, but in those taking the same-looking pill that happened to contain green tea compounds inside, consistent improvement, with women feeling lessening symptoms, each month better than the last. And, with that, an improved health-related quality of life month after month, significantly better than control. And, their blood counts got better too. The blood levels kept decreasing in the placebo group with all that continued excess blood loss every month. But, blood counts reversed in the green tea group. So, anemia significantly improved, because average blood flow significantly diminished. And, all this—the fibroid shrinkage, less pain, better periods— with no adverse effects.
So, not only results comparable to those for the drugs that are commonly used—without the side effects, but comparable results to uterine artery embolization, where they try to cut the blood supply to the fibroid, which is great—unless you accidently cut the blood supply to the rest of the uterus and cause uterine necrosis, one of many reported major complications, which also include death, not only of the fibroid but of the patient and other potential complications that may arise from accidently clogging off non-target arteries. So, a side effect free solution as good as a more invasive procedure is potentially better than in my book. They conclude that green tea compounds show promise as a safe and effective therapeutic agent for women with symptomatic fibroids. Such a simple, inexpensive, and relatively safe therapy could improve women’s health globally.
Now, relatively safe doesn’t mean risk-free. Although there were no liver function abnormalities detected, this was a small study. If you give green tea extract pills to a thousand women for a year, like they did in this breast cancer trial, in about 1 in 17 women, their liver started to get inflamed, a few of which became serious. Now, the dose they used in this study was twice that of the fibroid study; and, it’s not completely clear if the pills were the only cause. But, in general, we should try to avoid extracts and get nutrition in foods as grown, or at least foods as grown dunked in hot water, like green tea. Now, they had to use pills in this study, because they wanted it to be a double-blind study, and it’s hard to create a fake placebo tea that looks, smells, and tastes like the real thing. So, I don’t think we should take green tea extract pills; we should drink green tea. The problem is that the dose they used was like 11 cups a day worth, which would be a lot of caffeine. But, you could choose decaf, and it’s not outside the realm of possibility to drink a couple quarts of tea a day, especially if it’s going to shrink your fibroids so much you can keep your uterus or something. Though, for all we know, five cups of tea would work or three cups or one cup a day—no other dose has been tested. But, you can test it in your own life. If you have fibroids, it couldn’t hurt to add a few cups of green tea to your daily diet and see if you start feeling better.
Please consider volunteering to help out on the site.
- Islam MS, Segars JH, Castellucci M, Ciarmela P. Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target. Pharmacol Rep. 2017 Feb;69(1):57-70.
- Islam MS, Giampieri F, Janjusevic M, Gasparrini M, Forbes-Hernandez TY, Mazzoni L, Greco S, Giannubilo SR, Ciavattini A, Mezzetti B, Capocasa F, Castellucci M, Battino M, Ciarmela P. An anthocyanin rich strawberry extract induces apoptosis and ROS while decreases glycolysis and fibrosis in human uterine leiomyoma cells. Oncotarget. 2017 Apr 4;8(14):23575-23587.
- Wegienka G. Are uterine leiomyoma a consequence of a chronically inflammatory immune system? Med Hypotheses. 2012 Aug;79(2):226-31.
- Islam MS, Akhtar MM, Ciavattini A, Giannubilo SR, Protic O, Janjusevic M, Procopio AD, Segars JH, Castellucci M, Ciarmela P. Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids? Mol Nutr Food Res. 2014 Aug;58(8):1667-84.
- Fletcher NM, Saed MG, Abu-Soud HM, Al-Hendy A, Diamond MP, Saed GM. Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids. J Assist Reprod Genet. 2013 Jul;30(7):969-74.
- Malik M, Mendoza M, Payson M, Catherino WH. Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression. Fertil Steril. 2009 May;91(5 Suppl):2177-84.
- Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):283-99.
- Tsuiji K, Takeda T, Li B, Wakabayashi A, Kondo A, Kimura T, Yaegashi N. Inhibitory effect of curcumin on uterine leiomyoma cell proliferation. Gynecol Endocrinol. 2011 Jul;27(7):512-7.
- Zhang D, Al-Hendy M, Richard-Davis G, Montgomery-Rice V, Sharan C, Rajaratnam V, Khurana A, Al-Hendy A. Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice. Am J Obstet Gynecol. 2010 Mar;202(3):289.e1-9.
- Bartels CB, Cayton KC, Chuong FS, Holthouser K, Arian SE, Abraham T, Segars JH. An Evidence-based Approach to the Medical Management of Fibroids: A Systematic Review. Clin Obstet Gynecol. 2016 Mar;59(1):30-52.
- Zhang D, Rajaratnam V, Al-Hendy O, Halder S, Al-Hendy A. Green tea extract inhibition of human leiomyoma cell proliferation is mediated via catechol-O-methyltransferase. Gynecol Obstet Invest. 2014;78(2):109-18.
- Roshdy E, Rajaratnam V, Maitra S, Sabry M, Allah AS, Al-Hendy A. Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study. Int J Womens Health. 2013 Aug 7;5:477-86.
- Dostal AM, Samavat H, Bedell S, Torkelson C, Wang R, Swenson K, Le C, Wu AH, Ursin G, Yuan JM, Kurzer MS. The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial. Food Chem Toxicol. 2015 Sep;83:26-35.
- Schirf BE, Vogelzang RL, Chrisman HB. Complications of uterine fibroid embolization. Semin Intervent Radiol. 2006 Jun;23(2):143-9.
Image credit: Kristina DeMuth. Image has been modified.
Motion graphics by Avocado Video.
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.
What about dietary phytochemicals as a possible preventive and therapeutic option for uterine fibroids, plant based compounds with disease-preventive properties, found in whole grains, fruits, vegetables, bean, split peas, chickpeas, and lentils, herbs, spices, nuts, and certain beverages. The thought is, look, we know they can help regulate the initiation, promotion, and spread of cancerous tumors; so, what about benign tumors like fibroids? Most anti-cancer drugs on the market now, for example, were originally derived from plants or plant products; so, why not try to use plants to target the inflammation or blood supply of fibroids? Might fibroids be a consequence of chronic inflammation within the body? Well, we know that women with fibroids are more likely to eat more beef and ham, and fewer fruits and green vegetables, but whole plant foods don’t just have anti-inflammatory effects but antioxidant effects as well. When the amount of free radicals exceeds the protective effects of antioxidants, oxidative damage will occur, which has been implicated in a variety of disease states, including gynecological conditions, such as fibroids.
If you collect fresh fibroids, as well as normal uterine tissue from hysterectomy surgeries, the fibroid cells have significantly fewer antioxidant enzymes; so, might antioxidant rich foods help? Well, if you drip some strawberries in a petri dish, you can apparently kill of some fibroid tumor cells, while leaving normal uterus cells alone. But, what good does that do us. That’s only relevant if we can show those strawberry compounds get absorbed through our gut and achieve high enough concentrations in uterine tissue. The same with curcumin, the component of the spice turmeric. One of its so-called “miraculous” properties is suppressing the growth of uterine fibroid cells, but again that was just in vitro. Yes, an inhibitory effect was found, and at concentrations that don’t compromise the growth of regular uterine tissue. But, my patients are people, not petri dishes.
I mean, it’s neat to see what happens to human fibroid cells as you drip higher and higher concentrations of green tea compounds on them in a test tube, but I care less about what happens in vitro, or in mice, whether or not they have any clothes on. But there were no randomized, controlled clinical studies until, now, or at least 2013.
Subjects were randomized to green tea extract or placebo for 4 months. In the placebo group, fibroid volume increased 24%. That’s what fibroids do, they continue to grow; however, those randomized to the green tea group showed a reduction in total fibroid volume, and not just by a little, a dramatic decrease—shrunk almost a third–a highly significant difference. OK. But, did the women feel any better? Yes, a dramatic decrease in symptom severity, as well. In the placebo group, nothing much happened month after month, but in those taking the same-looking pill that happened to contain green tea compounds inside, consistent improvement, with women feeling lessening symptoms, each month better than the last. And, with that, an improved health-related quality of life month after month, significantly better than control. And, their blood counts got better too. The blood levels kept decreasing in the placebo group with all that continued excess blood loss every month. But, blood counts reversed in the green tea group. So, anemia significantly improved, because average blood flow significantly diminished. And, all this—the fibroid shrinkage, less pain, better periods— with no adverse effects.
So, not only results comparable to those for the drugs that are commonly used—without the side effects, but comparable results to uterine artery embolization, where they try to cut the blood supply to the fibroid, which is great—unless you accidently cut the blood supply to the rest of the uterus and cause uterine necrosis, one of many reported major complications, which also include death, not only of the fibroid but of the patient and other potential complications that may arise from accidently clogging off non-target arteries. So, a side effect free solution as good as a more invasive procedure is potentially better than in my book. They conclude that green tea compounds show promise as a safe and effective therapeutic agent for women with symptomatic fibroids. Such a simple, inexpensive, and relatively safe therapy could improve women’s health globally.
Now, relatively safe doesn’t mean risk-free. Although there were no liver function abnormalities detected, this was a small study. If you give green tea extract pills to a thousand women for a year, like they did in this breast cancer trial, in about 1 in 17 women, their liver started to get inflamed, a few of which became serious. Now, the dose they used in this study was twice that of the fibroid study; and, it’s not completely clear if the pills were the only cause. But, in general, we should try to avoid extracts and get nutrition in foods as grown, or at least foods as grown dunked in hot water, like green tea. Now, they had to use pills in this study, because they wanted it to be a double-blind study, and it’s hard to create a fake placebo tea that looks, smells, and tastes like the real thing. So, I don’t think we should take green tea extract pills; we should drink green tea. The problem is that the dose they used was like 11 cups a day worth, which would be a lot of caffeine. But, you could choose decaf, and it’s not outside the realm of possibility to drink a couple quarts of tea a day, especially if it’s going to shrink your fibroids so much you can keep your uterus or something. Though, for all we know, five cups of tea would work or three cups or one cup a day—no other dose has been tested. But, you can test it in your own life. If you have fibroids, it couldn’t hurt to add a few cups of green tea to your daily diet and see if you start feeling better.
Please consider volunteering to help out on the site.
- Islam MS, Segars JH, Castellucci M, Ciarmela P. Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target. Pharmacol Rep. 2017 Feb;69(1):57-70.
- Islam MS, Giampieri F, Janjusevic M, Gasparrini M, Forbes-Hernandez TY, Mazzoni L, Greco S, Giannubilo SR, Ciavattini A, Mezzetti B, Capocasa F, Castellucci M, Battino M, Ciarmela P. An anthocyanin rich strawberry extract induces apoptosis and ROS while decreases glycolysis and fibrosis in human uterine leiomyoma cells. Oncotarget. 2017 Apr 4;8(14):23575-23587.
- Wegienka G. Are uterine leiomyoma a consequence of a chronically inflammatory immune system? Med Hypotheses. 2012 Aug;79(2):226-31.
- Islam MS, Akhtar MM, Ciavattini A, Giannubilo SR, Protic O, Janjusevic M, Procopio AD, Segars JH, Castellucci M, Ciarmela P. Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids? Mol Nutr Food Res. 2014 Aug;58(8):1667-84.
- Fletcher NM, Saed MG, Abu-Soud HM, Al-Hendy A, Diamond MP, Saed GM. Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids. J Assist Reprod Genet. 2013 Jul;30(7):969-74.
- Malik M, Mendoza M, Payson M, Catherino WH. Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression. Fertil Steril. 2009 May;91(5 Suppl):2177-84.
- Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):283-99.
- Tsuiji K, Takeda T, Li B, Wakabayashi A, Kondo A, Kimura T, Yaegashi N. Inhibitory effect of curcumin on uterine leiomyoma cell proliferation. Gynecol Endocrinol. 2011 Jul;27(7):512-7.
- Zhang D, Al-Hendy M, Richard-Davis G, Montgomery-Rice V, Sharan C, Rajaratnam V, Khurana A, Al-Hendy A. Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice. Am J Obstet Gynecol. 2010 Mar;202(3):289.e1-9.
- Bartels CB, Cayton KC, Chuong FS, Holthouser K, Arian SE, Abraham T, Segars JH. An Evidence-based Approach to the Medical Management of Fibroids: A Systematic Review. Clin Obstet Gynecol. 2016 Mar;59(1):30-52.
- Zhang D, Rajaratnam V, Al-Hendy O, Halder S, Al-Hendy A. Green tea extract inhibition of human leiomyoma cell proliferation is mediated via catechol-O-methyltransferase. Gynecol Obstet Invest. 2014;78(2):109-18.
- Roshdy E, Rajaratnam V, Maitra S, Sabry M, Allah AS, Al-Hendy A. Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study. Int J Womens Health. 2013 Aug 7;5:477-86.
- Dostal AM, Samavat H, Bedell S, Torkelson C, Wang R, Swenson K, Le C, Wu AH, Ursin G, Yuan JM, Kurzer MS. The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial. Food Chem Toxicol. 2015 Sep;83:26-35.
- Schirf BE, Vogelzang RL, Chrisman HB. Complications of uterine fibroid embolization. Semin Intervent Radiol. 2006 Jun;23(2):143-9.
Image credit: Kristina DeMuth. Image has been modified.
Motion graphics by Avocado Video.
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Title
The Best Food for Fibroids
LicenseCreative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Content URLDoctor's Note
I talk more about diet and fibroids in my last video, The Best Diet for Fibroids.
For more remarkable studies on what individual foods can do for women’s health, see:
- Flaxseeds for Breast Pain
- Fennel Seeds for Menstrual Cramps and PMS
- Benefits of Ginger for Menstrual Cramps
- Is Soy Healthy for Breast Cancer Survivors?
I have many other videos on green tea and on men’s health, too. See, for example, Preventing Prostate Cancer with Green Tea and Treating Prostate Cancer with Green Tea.
You may also be interested in Natural Treatment for Acne and Fungal Infections.
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